Navigation Links
PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity
Date:6/12/2008

- Data Presented at the 31st European Cystic Fibrosis Conference -

SOUTH PLAINFIELD, N.J. and PRAGUE, Czech Republic, June 12 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC) today announced promising new data from two studies of PTC124 in cystic fibrosis (CF). Results from an Israeli Phase 2a extension study evaluating three months of oral PTC124 treatment in adult patients with nonsense-mutation-mediated CF demonstrated statistically significant improvements in the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein and a statistically significant mean [28%] decrease in the frequency of cough, one of the most prominent and burdensome CF-related symptoms. Results from the Hadassah University Hospital in Israel were presented today by Michael Wilschanski, M.D., Director, Pediatric Gastroenterology, and by Eitan Kerem, M.D., principal investigator and head of the Department of Pediatrics and Cystic Fibrosis Center. Separately, results from a European study evaluating 14-day courses of PTC124 in pediatric patients with nonsense-mutation-mediated CF confirmed the CFTR activity observed in previous short-term studies in adult patients. Data from the European study were presented today by Isabelle Sermet-Gaudelus, M.D., Ph.D., principal investigator at l'Hopital Necker-Enfants Malade.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010919/PTCLOGO )

Patients with CF lack adequate levels of the CFTR protein, a chloride channel that maintains proper hydration of epithelial surfaces in the lung, pancreas, and liver. Patients with nonsense-mutation-mediated CF generally have a severe form of CF because virtually no CFTR protein is produced. Previous studies of PTC124 adult patients with CF evaluated nasal transepithelial potential difference (TEPD) as a surrogate for the presence and activity of the CFTR protein. Across the short- and long-term
'/>"/>

SOURCE PTC Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
2. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
3. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
4. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
5. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
6. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
7. Protalix BioTherapeutics Treats First Patient in Phase III Clinical Trial of prGCD
8. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
9. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
10. Cell Therapeutics, Inc. (CTI) Launches Phase III Study for Pixantrone in Relapsed Indolent Non-Hodgkins Lymphoma (NHL)
11. Cell Therapeutics, Inc. (CTI) Sponsors Panel Discussion on Women and Lung Cancer on Capitol Hill
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... SALT LAKE CITY , Aug. 27, 2014 ... that will expand its current Salt Lake City ... operations currently underway outside of Utah ... state over the next 20 years. " ... immense engineering and technical talent, many of whom can be ...
(Date:8/27/2014)... 27, 2014 Decision Resources Group finds that ... Memphis health system and hospital sector ... with rivals Methodist Le Bonheur Healthcare and Baptist Memorial ... coordinate patient care. In addition, a national contract recently ... health plan enrollment in the Memphis ...
(Date:8/27/2014)... 27, 2014 ISPE , the International ... released a preview of its Drug Shortages Prevention ... drug shortages and maintain a robust and reliable supply ... Plan, a first for the industry, was developed by ... and describes how industry can best prevent drug shortages ...
Breaking Medicine Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 4Memphis-area Health Systems Turn Attention to Clinical Integration 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 3ISPE Releases First Look at its Plan to Prevent Drug Shortages 4
... MTD ) today announced it will host a ... November 4, 2010 at 5:00 p.m. Eastern Time. To hear ... on the Company,s website. A replay of the webcast will ... TOLEDO is a leading global supplier of precision instruments and ...
... WEST PALM BEACH, Fla., Oct. 28 The ... pain is where it all begins.  Lasting for ... rest, time and medication.  For many, that is ... converts to chronic pain, and new methods must ...
Cached Medicine Technology:Technology, New Therapies Reduce Use of Addictive Prescriptions 2
(Date:8/28/2014)... Texas (PRWEB) August 28, 2014 MMAR ... The program is a chance for regular customers to ... Medical without the need for a wholesale license. It’s ... coaches, semi-professional athletic programs and others who regularly purchase ... , “Whether supporting your own active lifestyle or ...
(Date:8/28/2014)... Loudoun County, VA (PRWEB) August 28, 2014 ... secure software development, today announced that it has ... awarded 10/22/2013 with the performance start date of ... the Department of Homeland Security (DHS) agency that ... Under the contract, Coveros and InfoZen will automate ...
(Date:8/28/2014)... Fort Worth, Texas (PRWEB) August 28, 2014 ... experiencing significant growth over the past few years. The new ... - will offer higher quality and larger office space than ... for growth. , “We are pleased about our new ... Laurenzo said. “While our suite will be double in size ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 UniVoIP, Inc, ... El Segundo, CA, today announced that they have been ... of Los Angeles Local Small Business Enterprise (Local SBE) ... and certified by the state of California and LA ... Cloud-hosted Telephony Solution to governmental agencies throughout ...
(Date:8/27/2014)... Aeroflow Healthcare has announced it ... of a strategic expansion of its durable medical ... ownership of new businesses through additional resources and ... , Last week, the company announced that it ... increase service in the High Point/Greensboro/Winston-Salem area. This ...
Breaking Medicine News(10 mins):Health News:MMAR Medical Announces Customer Membership Program 2Health News:Coveros Partners with InfoZen on USCIS Transformation Integration Award 2Health News:Cloud PBX Provider UniVoIP Gets Certified by the State of California and the County of Los Angeles Under the Local Small Business Enterprise (SBE) Preference Program 2Health News:Aeroflow Healthcare Seeks Strategic Acquisition Opportunities 2
... Applications Now Available for the 2008-2009 Academic ... American,Association of Colleges of Nursing (AACN) is ... have been selected to receive The California,Endowment-AACN ... program was developed to provide financial support, ...
... Governor Edward G.,Rendell today said the Pennsylvania Children,s ... at specific Rite Aid,stores in south central Pennsylvania on ... "We,re working hard to make sure every parent understands ... be covered by CHIP," Governor,Rendell said. "Through Cover All ...
... 18 Oakwood Southshore,Medical Center (OSMC) is one ... a generous gift from Anthony J. Pellegrino. Pellegrino,donated ... "The Southshore Promise is really our pledge ... Oakwood Southshore,Medical Center. "We are in the business ...
... Impact on ... Meth Use in Montana, PALO ALTO, Calif., Sept. ... of the,United States Senate today. Siebel was invited to brief the panel ... Montana --,where the Meth Project implemented its first statewide program. Since the,launch ...
... Collins Industries, a,leading manufacturer of specialty vehicles in ... Bus, Inc. production facility in Bluffton,Ohio. Company officials plan ... in South Hutchinson, Kansas by November 9, 2007. ... Bluffton, Ohio was,certainly a difficult decision. Since the purchase ...
... 150,children,s hospital CEOs, medical directors, trustees and other ... to,Capitol Hill on Wednesday, September 19 to call ... (SCHIP). At noon at the Retired,Officers Association Building, ... (D-MT) and Sherrod Brown (D-OH) on the state ...
Cached Medicine News:Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 2Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 3Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 4Health News:Governor Rendell Announces CHIP Enrollment Clinics at Several Rite Aid Stores 2Health News:$1 Million Gift Boosts Downriver Community 2Health News:Meth Project Chairman Testifies Before U.S. Senate Finance Committee 2Health News:Meth Project Chairman Testifies Before U.S. Senate Finance Committee 3Health News:Company Announces Closure of Bluffton, Ohio Plant 2Health News:Children's Hospitals in Washington to Lobby Congress to Reauthorize SCHIP Now 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: