Navigation Links
PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy
Date:10/18/2007

le improvement in the staining for dystrophin from muscle biopsies. Response did not appear to be dependent on type of nonsense mutation.

Blood levels of muscle-derived creatine kinase were also measured as assessments of muscle integrity. Statistically significant reductions in the concentrations of muscle-derived creatine kinase were observed during PTC124 treatment. In addition, several parents and teachers reported that boys participating in the study had improvements in terms of greater activity level and increased endurance during the study duration.

"We are very encouraged by these results, which show improvements in critical biomarkers of DMD," said presenter and study investigator, Carsten Bonnemann, M.D., Assistant Professor Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine and Co-Director of the Neuromuscular Program, Children's Hospital of Philadelphia. "The combined in vitro and in vivo evidence of enhanced dystrophin expression and reduced muscle fragility offer signals of pharmacological activity that we hope to translate into potential clinical benefit for patients with DMD."

"Coupled with the emerging safety profile of PTC124, these data provide the impetus for moving forward rapidly to initiate longer-term studies for boys with DMD," said Langdon Miller, M.D., Chief Medical Officer of PTC. "We are actively working with our clinical investigators and the regulatory agencies to finalize plans for additional clinical trials and we look forward to commencing these studies in the coming months."

Stuart W. Peltz, Ph.D., President and Chief Executive Officer of PTC Therapeutics added, "These results, combined with the data presented earlier this month at the Child Neurology Society meeting and North American Cystic Fibrosis Conference, further support our belief that PTC124 represents a paradigm shift in the treatment of genetic disorders. Our future plans for PTC124 inc
'/>"/>

SOURCE PTC Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. GTC Biotherapeutics to Webcast Corporate Presentation at the C.E. Unterberg, Towbin Emerging Growth Life Opportunities Conference
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
7. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
8. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held medical ... an exclusive distributor agreement with ITOCHU Corporation (Tokyo Stock ... system for the treatment of cancer in ... is the world,s first and only MRI-guided radiation therapy ...
(Date:1/22/2015)... UPI ), a medical device company that develops, manufactures ... today reported financial results for the fiscal 2015 third ... the Company,s Urgent ®  PC Neuromodulation System grew 14.5% ... compared to $3.9 million in the third quarter of ...
(Date:1/22/2015)... , Jan. 22, 2015 /PRNewswire/ - Pivotal Therapeutics Inc. (OTCQX:PVTTF; ... a focus on Omega-3 therapies for cardiovascular disease and overall ... the Company,s accomplishments in 2014 and its outlook for 2015 ... Dear Fellow Shareholders, We would like to take ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Pivotal Therapeutics: Year in Review and CEO Update 2Pivotal Therapeutics: Year in Review and CEO Update 3Pivotal Therapeutics: Year in Review and CEO Update 4Pivotal Therapeutics: Year in Review and CEO Update 5Pivotal Therapeutics: Year in Review and CEO Update 6Pivotal Therapeutics: Year in Review and CEO Update 7
... Dec. 5, 2011  Pharmacy benefit managers Express Scripts ... government, labor unions, and consumers between $51 billion and ... according to a new report released today by economists ... of Compass Lexecon .  (Logo:  ...
... Nearly one million doses of the NOBIVAC Canine Flu ... and rescue groups in 49 states as part of ... the Petfinder.com Foundation and Merck Animal Health.   The grant ... canine influenza virus (CIV), better known as dog flu ...
Cached Medicine Technology:Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 2Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 3Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 4Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 5Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 6Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 7Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 8Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 9Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 10Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 11Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 12Express Scripts and Medco Save Americans Tens of Billions in Healthcare Costs, New Economic Report Shows 13Nearly 1,400 Animal Shelters and Rescues, in Partnership With Veterinarians, Build Community Immunity Against Canine Influenza 2
(Date:1/22/2015)... As interest in the value of spiritual ... worldwide, Rev. Eric J. Hall , president and CEO ... will be the keynote speaker on January 27 at an ... system. , The conference, “Hope and Resilience: Innovative and Interdisciplinary ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting a list ... policy . , Some types of vehicles cannot be covered ... released blog post to see if their vehicle qualifies for auto ... some of the cars that cannot be covered by a plan. ...
(Date:1/22/2015)... January 22, 2015 Step into a ... the Science Museum of Virginia. Wicked Plants, the Museum’s ... Plants unearths 75 poisonous, carnivorous and diabolical plants inside ... room to uncover the biochemical, physical and neurological processes ...
(Date:12/26/2014)... 2014 The US represents the largest market ... 2013, GlobalData’s forecast estimates that sales of branded therapies were ... to the high incidence of the disease, high drug treatment ... and China. Increased sales of CRC therapies over the forecast ...
(Date:12/26/2014)... December 26, 2014 Cooking and warming ... of 5. This score reflects slightly positive negotiation conditions for ... switching costs and a low level of price volatility. “However, ... for cooking and warming equipment and high volatility in the ...
Breaking Medicine News(10 mins):Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:Wicked Plants are taking over the Science Museum of Virginia 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Cooking & Warming Equipment Procurement Category Market Research Report from IBISWorld has Been Updated 3
... could soon be storing essential medical information under the skin ... ,Devices the size of a grain of rice that ... quick access to the records of chronically ill patients, the ... ,The association adopted a policy Monday stating that the devices ...
... study published on bmj.com today (Tuesday 26 June) ... patients with well-controlled, non-insulin dependent (type 2) diabetes. ... the American Diabetes Association Conference, suggests that current ... reviewed. ,Non-insulin dependent (type 2) diabetes ...
... people with freakish traits. ,The former 'Baywatch' ... Times Square Odditorium in New York. ,The 35-year-old ... abnormality during a dance class. ,"I have double-jointed ... York Daily News quoted Electra, as saying. ,Meanwhile ...
... National Testing Day in the US. ,National HIV Testing ... National Association of People with AIDS (NAPWA-US) to ... testing. ,The Centers for Disease Control and ... are HIV-positive but are unaware of their status. HIV ...
... shocked when she sees how skinny she was during her 'Friends' ... she thought that she looked great, when she looks back at ... sitcom she can't help but cringe over her thin frame. ... I was really, really thin. I thought I looked great. In ...
... weekend had a gala time celebrating annual Monsoon festival, which ... ,Monsoon festival is a legacy Goans have inherited ... liberated in 1961. ,During the celebrations, Goans jumped ... ,In villages, the festival was celebrated with much traditional fervour. ...
Cached Medicine News:Health News:Storing Medical Info Under Your Skin 2Health News:Questions Over Value of Glucose Monitoring for Non-insulin Using Diabetes Patients 2Health News:US Officials Urge Testing for HIV as Health Crisis Intensifies 2Health News:US Officials Urge Testing for HIV as Health Crisis Intensifies 3Health News:Goans Celebrate Monsoon Festival 2
... 20l Barrier Tips. Low binding technology that significantly ... to the tip. Most other filter tips are ... is on liquid not adhering to the pipet ... which reduces the binding of valuable molecules such ...
Ideal for use with low volume samples on the Biomek robotic pipetting systems, the ART 20R provides guaranteed protection for your expensive workstation....
Hydrophobic PE filter without self-sealing additives, permits sample recovery after accidental over-pipetting. All filters are sterile (to USP, DAB, Ph.Eur. standards) and PCR clean (free from human ...
... Aerosol barrier tips eliminate false signals ... designed and tested, Promega Barrier Tips ... with amplified nucleic acids (PCR(a)), radioactive ... forensic and serological specimens. , ,Promega ...
Medicine Products: