Navigation Links
PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy
Date:10/18/2007

le improvement in the staining for dystrophin from muscle biopsies. Response did not appear to be dependent on type of nonsense mutation.

Blood levels of muscle-derived creatine kinase were also measured as assessments of muscle integrity. Statistically significant reductions in the concentrations of muscle-derived creatine kinase were observed during PTC124 treatment. In addition, several parents and teachers reported that boys participating in the study had improvements in terms of greater activity level and increased endurance during the study duration.

"We are very encouraged by these results, which show improvements in critical biomarkers of DMD," said presenter and study investigator, Carsten Bonnemann, M.D., Assistant Professor Neurology and Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine and Co-Director of the Neuromuscular Program, Children's Hospital of Philadelphia. "The combined in vitro and in vivo evidence of enhanced dystrophin expression and reduced muscle fragility offer signals of pharmacological activity that we hope to translate into potential clinical benefit for patients with DMD."

"Coupled with the emerging safety profile of PTC124, these data provide the impetus for moving forward rapidly to initiate longer-term studies for boys with DMD," said Langdon Miller, M.D., Chief Medical Officer of PTC. "We are actively working with our clinical investigators and the regulatory agencies to finalize plans for additional clinical trials and we look forward to commencing these studies in the coming months."

Stuart W. Peltz, Ph.D., President and Chief Executive Officer of PTC Therapeutics added, "These results, combined with the data presented earlier this month at the Child Neurology Society meeting and North American Cystic Fibrosis Conference, further support our belief that PTC124 represents a paradigm shift in the treatment of genetic disorders. Our future plans for PTC124 inc
'/>"/>

SOURCE PTC Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. GTC Biotherapeutics to Webcast Corporate Presentation at the C.E. Unterberg, Towbin Emerging Growth Life Opportunities Conference
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
7. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
8. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... 2014  Rebiotix Inc. announced this morning that results of ... RBX2660 (microbiota suspension) will be presented in two posters and ... Philadelphia from October 8-12. ... session on Thursday, October 9, 2014: Poster: RBX2660 ... Interim Analysis of the PUNCH-CD Phase 2 Safety Study ...
(Date:9/17/2014)... 17, 2014  Bayer HealthCare will present data on ... th Annual Meeting, which takes place September 18-20 ... which will be shared through poster presentations, showcase Bayer,s ... Data will be presented in a scientific forum. ... in hemophilia A patients, Bayer is maintaining its commitment ...
(Date:9/17/2014)... September 17, 2014 According to ... Component (Sensor, Battery, Memory Device, Display, & Microprocessor/MCU), by ... Wellness), and by Geography - Global Forecast to 2020", ... market is expected to reach $56.50 Billion by 2020, ... 2020. Browse 235 market data Tables and ...
Breaking Medicine Technology:PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 2PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 3PUNCH CD Study Drug Targeting Recurrent C. difficile Infection to be Presented at IDWeek 2014 4Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 2Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 3Bayer to Present Data on Hemophilia Research at NHF in Washington, D.C. 4Medical Electronics Market Worth $56.50 Billion by 2020 2Medical Electronics Market Worth $56.50 Billion by 2020 3Medical Electronics Market Worth $56.50 Billion by 2020 4
... (Nasdaq: ENDP ) today announced that it will present ... 2011 at 3:45 p.m. ET.  Dr. Ivan Gergel executive vice president ... programs. The presentation will be webcast live and can ... investors section.   About Endo ...
... nation,s leading retail pharmacy, brings its "To Your Health" ... Texas. The program will provide free preventive health screenings ... through November as a way to help citizens determine ... a path to better health. (Logo: ...
Cached Medicine Technology:CVS/pharmacy Debuts the 'To Your Health' Program in Dallas and Fort Worth Texas, Bringing More Than 80 Free Health Screening Events to the Community 2CVS/pharmacy Debuts the 'To Your Health' Program in Dallas and Fort Worth Texas, Bringing More Than 80 Free Health Screening Events to the Community 3
(Date:9/18/2014)... 18, 2014 One Week Kitchens will have ... Bloomsburg Fair beginning this Saturday. Their display will be inside ... example of the products and design services that are offered ... countertops for fair-goers to see. This display won ‘Most Beautiful ... this year and really is something to see. , ...
(Date:9/18/2014)... Each year, Norman Regional Hospital in Norman, ... National Health IT (NHIT) Week to celebrate the contributions ... Regional show its gratitude, Access, the leading provider ... giveaway items to support their NHIT Week program. , ... free lunches, Norman Regional is spending time this week ...
(Date:9/18/2014)... Lake City, Utah (PRWEB) September 18, 2014 ... Now Spoonful of Comfort, an online food delivery service provider, ... , New Country Fresh Tomato Basil soup is a nod ... begins, of course, with a tangy tomato base, then Spoonful ... asiago and parmesan cheeses. A flashback to childhood has never ...
(Date:9/18/2014)... Computer Resources of America, Inc. (CRA), ... York City, has been awarded a contract to provide ... with stores in over 150 countries. The services will ... being the retailer’s dispatch arm handling all IT support ... Chief Executive Officer of CRA said, “We are excited ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 With ... have special functions of adjusting human body physiology, ... won great popularity with a variety of specific ... food in China reached RMB187.4 billion, up 12.0% ... during 2006-2013. , View Full Report at ...
Breaking Medicine News(10 mins):Health News:One Week Kitchens Taking Display to Bloomsburg Fair 2Health News:Access Helps Norman Regional Hospital Celebrate Its Staff During National Health IT Week 2014 2Health News:An Old Classic Brings New Soup Delivery Options to Spoonful of Comfort 2Health News:CRA Awarded Managed Support Contract for Global Retailer 2Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 2Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 3Health News:China Health Food Industry Size 2014 Market Analysis, Growth, Trends and Forecast Report 2017: MarketResearchReports.biz 4
... steps to see that the woman who sued them for ?250,000 ... eventually gave birth to her daughter Jayde and sued the Perth ... ,However, the Perth Sheriff Court was told that ... abortion would be successful. Ms Dow had the procedure done in ...
... prescribed to treat Parkinson’s disease revealed shocking results. After ... Parkinson's disease could turn patients into compulsive gamblers. Scientists ... association between pathological gambling and the drugs. ... the brain. Dopamine is a chemical that is naturally ...
... from urinary incontinence are more likely to be depressed, says ... until you get to a restroom. The condition is twice ... and can happen for various medical reasons. ,The ... condition alone and doctors 'need to be attentive to these ...
... Medical Council (GMC) here has warned a doctor of Indian ... at his clinic// because he was an asylum seeker in ... the man treatment because "he was not British and did ... ,Chandra, who studied medicine in India and has ...
... worthwhile to consider kicking the smoking habit, even at older ... enhances the risk of dying in middle age for both ... of premature death. The study, which scores very high, one ... this subject, that studies the habit of smoking and its ...
... might be fun for kids may lead to bacterial ... conducted on petting zoos and feeding animals//. The results ... unaware that simple preventive measures such as hand washing ... three such similar studies would be presented at the ...
Cached Medicine News:Health News:Petting Zoos Can Lead To Bacterial Infection And Illness 2
1% tryptone, 0.5% yeast extract, 1.0% Sodium Chloride. 1.5% agararose...
Luria bertani broth: 1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride....
Luria bertani broth: 1.0% Tryptone, 0.5% Yeast Extract, 1.0% Sodium Chloride....
Inoculum Broth with Calcium Chloride and Phytone....
Medicine Products: