Navigation Links
PTC Therapeutics Announces Additional Results from Phase 2 Study of PTC124 in Duchenne Muscular Dystrophy
Date:10/18/2007

Data Presented at the World Muscle Society International Congress

SOUTH PLAINFIELD, N.J., Oct. 18 /PRNewswire/ -- PTC Therapeutics, Inc. (PTC), a biopharmaceutical company focused on the discovery, development, and commercialization of small-molecule drugs targeting post-transcriptional control mechanisms, today announced additional data from a Phase 2 clinical trial of PTC124 in patients with Duchenne muscular dystrophy (DMD) due to a nonsense mutation. The results, which include data from all three cohorts of the study, show that administration of PTC124 is associated with qualitative increases in muscle dystrophin expression and with reductions in serum creatine kinase values. These data were presented today at the World Muscle Society (WMS) International Congress in Taormina, Italy.

(Logo: http://www.newscom.com/cgi-bin/prnh/20010919/PTCLOGO )

Patients with DMD are boys and young men who lack dystrophin, a protein that is critical to the structural stability of muscle fibers. This Phase 2 multi-site, open-label, dose-ranging clinical trial enrolled 38 boys with loss of dystrophin due to a nonsense mutation in the dystrophin gene. Participants also had substantially elevated serum creatine kinase levels due to the disease, and symptoms associated with DMD. Boys enrolled in the trial received 28 days of PTC124 treatment at one of three dose levels, with the primary endpoint of the trial being an increase in dystrophin expression in muscle. Pre- and post-treatment muscle biopsies and blood analyses to assess muscle-derived creatine kinase were available from all 38 patients.

An in vitro analysis demonstrated PTC124-induced dystrophin expression in cultured muscle cells from all 35 (100%) of the boys with samples evaluable in this analysis. The in vivo data indicated that, across all three dose levels of PTC124, 18/38 (47%) of patients demonstrated visib
'/>"/>

SOURCE PTC Therapeutics, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. GTC Biotherapeutics to Webcast Corporate Presentation at the C.E. Unterberg, Towbin Emerging Growth Life Opportunities Conference
5. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
6. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
7. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
8. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
9. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
10. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
11. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... ON , Aug. 21, 2014 /CNW/ - Eisai Limited ... the introduction of the first-of-its-kind comic book available in ... tool, has been designed specifically to educate children and their ... Canada affecting more than 300,000 Canadians. Eisai ... health care (hhc) , in which the patient is central ...
(Date:8/21/2014)... 21, 2014 /PRNewswire-iReach/ -- Inc. magazine ... the third straight year, No. 349 in Health ... ranking of the nation,s fastest-growing private companies. The ... most important segment of the economy—America,s independent entrepreneurs. ... Pizza, LinkedIn, Zillow, and many other well-known names ...
(Date:8/21/2014)... 2014  Seventy-one percent of Americans believe the abuse of ... public health and safety issue in the United ... today by Repass & Partners, a Cincinnati ... the severity of the prescription medication abuse problem and the ... serious health situation facing our country," Rex Repass , ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 2Carolina's HME Named for Third Straight Year to Inc. Magazine's List of America's Fastest-Growing Private Companies--the Inc. 5000 3Consumers Desperate For Measures To Curb Prescription Drug Abuse 2Consumers Desperate For Measures To Curb Prescription Drug Abuse 3
... last two years the Lap Band has skyrocketed to fame ... individuals. As a result, the number of surgeons providing this ... caliber of skill sometimes varying greatly from one surgeon to ... Dr. Michael Feiz has taken the standards of "bedside manner" ...
... JOLLA, Calif., June 21, 2011 Healthcare information technology ... But several pivotal decisions lie ahead with respect to ... critical issues facing healthcare leaders will be examined in ... June 28, 2011 from University of California San Diego ...
Cached Medicine Technology:VIP Care for Lap Band Patients Leads to Life Changing Results 2Health Information Technology: UC San Diego New Seminar Explores Four Critical Issues 2
(Date:8/21/2014)... York, NY (PRWEB) August 21, 2014 ... can often have larger discounts for specific protection plans, ... is now helping consumers to quote life insurance from ... , The local agents that appear inside of ... offer a fast method of price reviews this year. ...
(Date:8/21/2014)... City, Utah (PRWEB) August 21, 2014 ... is pleased to announce the addition of Kerry ... 30 years of healthcare management experience, Gillespie brings ... experience includes multiple executive management positions with prominent ... recently Kerry served as President of Triad Isotopes, ...
(Date:8/21/2014)... 21, 2014 The costs for maintaining pet health ... according to new insurance industry studies. The Quotes Pros company is ... locate affordable plans from all 50 states at http://quotespros.com . ... $50 for a routine visit or complex surgery can use the ... of the system will be asked to provide a zip code ...
(Date:8/21/2014)... NY (PRWEB) August 21, 2014 ... trend among their patients. Alternative medicine is on ... due to millenials. According to The Fiscal Times, ... medical treatments over conventional medicine. , The Fiscal ... how many millenials are embracing alternative medicine. The ...
(Date:8/21/2014)... August 21, 2014 Pulmonary Hypertension ... an Education Forum for PH patients and families ... Pulmonary Hypertension Association – the country’s ... ways to prevent and cure pulmonary hypertension (PH) ... the functioning of the heart and can lead ...
Breaking Medicine News(10 mins):Health News:Life Insurance from Local Agents Now Priced Nationally Through Complimentary Tool Online 2Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2Health News:Pet Insurance Finder for 50 States Launched at Insurance Website Online 2Health News:Van Uden Center Sees Growth in Alternative Medicine 2Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 2Health News:Pulmonary Hypertension Association Goes On the Road to Houston With an Education Forum for PH Patients and Families to Help Fight Rare Lung Disease 3
... (HealthDay News) -- The shingles vaccine is generally safe and ... Shingles, which affects more than 1 million people each year ... by the dormant chickenpox virus, which can reactivate and replicate, ... risk because immunity against the virus that causes shingles declines ...
... By Denise Mann HealthDay Reporter , ... low levels of the heavy metal cadmium may fuel ... them to spread, preliminary research indicates. Found in ... soil and water. Some other main sources of cadmium ...
... WellPoint announced today that Indiana University Melvin and ... to help shape WellPoint,s new health care solutions. ... commercial applications utilizing IBM Watson to help improve ... to make the most informed, personalized treatment decisions ...
... will give you the adult compulsive gambler. That is the ... , a journal published by the Association for Psychological Science. ... toddlerhood, the study found that "people who were rated at ... than other three-year old children were twice as likely to ...
... Clinical Psychological Science ,Association for Psychological Science,s new ... (April 23, 2012) The Association for Psychological Science ... Science , a new peer-reviewed journal focused on publishing ... cutting-edge research across a wide range of conceptual views, ...
... The latest scientific research in children,s health will be ... Academic Societies Annual Meeting. More than 6,500 leaders in ... attend the meeting at the Hynes Convention Center. ... who are conducting original research in children,s health. More ...
Cached Medicine News:Health News:Shingles Vaccine Safe, Underutilized, Study Says 2Health News:Can Heavy Metal in Foods, Cosmetics Spur Breast Cancer Spread? 2Health News:IU Simon Cancer Center joins WellPoint in developing health care solutions 2Health News:IU Simon Cancer Center joins WellPoint in developing health care solutions 3Health News:That impulsive, moody preschooler may grow up to be a problem gambler 2Health News:Association for Psychological Science, SAGE launch Clinical Psychological Science 2Health News:Leaders in children's health to gather in Boston 2
... stereomicroscopes are of the single-objective ... mature modular design they optimally ... hand. This is an advantage ... applications will appreciate, not least ...
6.3X Zoom Ratio - Boasting magnifications from 0.8X to 5X, the twin zooming objective optical system developed exclusively by Nikon provides a zoom ratio of 6.3:1. Clickstops at 1X intervals allow ob...
10:1 Zoom Ratio - The parallel optical system of the SMZ-1000 has a 10:1 zoom with clickstops at 1X intervals. It features a zoom range of 0.8X to 8.0X and total magnification (depending on eyepieces...
Fixed Versatility - With a diverse selection of body tubes, stands, lighting techniques and Nikon's world-renowned optics, this modular microscope can be configured to fit nearly any application....
Medicine Products: