Navigation Links
PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference
Date:6/1/2009

Oral CCR9 Antagonist Demonstrates Clinical Efficacy with Favorable Tolerability Profile

MOUNTAIN VIEW, Calif., June 1 /PRNewswire/ -- ChemoCentryx, Inc., announced that Phase II/III clinical data from the company's PROTECT-1 (the Prospective Randomized Oral Therapy Evaluation in Crohn's disease Trial) of Traficet-EN(TM) (CCX282-B) in patients with moderate-to-severe Crohn's disease demonstrated evidence of clinical efficacy in the reduction of disease severity, as defined by a decrease from baseline in the Crohn's Disease Activity Index (CDAI) score of at least 70 points over the course of 12 weeks; the more stringent criterion of at least a 100 point decrease in the CDAI score was also met by week 12. In addition, Traficet-EN treatment resulted in colonoscopic evidence of improvement. These data, reported from the Induction Stage of the ongoing PROTECT-1 trial, were presented at Digestive Disease Week (DDW) 2009 in Chicago, IL, by Satish Keshav, M.D., Ph.D., Department of Gastroenterology, John Radcliffe Hospital, Oxford University, in an oral session today.

The study, "PROTECT-1 Study Demonstrated Efficacy of the Intestine-Specific Chemokine Receptor Antagonist CCX282-B (Traficet-EN) in Treatment of Patients with Moderate to Severe Crohn's Disease," showed that the 500 mg once-daily dose (QD) of Traficet-EN in patients with small bowel and/or colonic Crohn's disease was consistently superior to placebo across multiple efficacy endpoints. At week 12, the CDAI greater than or equal to 70-point response was 61 percent in the 500 mg QD group versus 47 percent for placebo (p=0.039). Similarly, the CDAI greater than or equal to 100-point response was 55 percent in this group versus 40 percent for placebo (p=0.029). In his oral presentation, Dr. Keshav further noted that colonoscopic evidence of improvement based on the Crohn's Disease Endoscopic Inde
'/>"/>

SOURCE ChemoCentryx, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohns Disease
2. Neurobiological Technologies Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program
3. Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
4. Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)
5. Entremed Presents Results of ENMD-2076 Phase 1 Study in Advanced Cancer Patients
6. TNFerade(TM) Phase III Data Presented at ASCO
7. Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation
8. Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
9. Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting
10. Video: Phase III Study Data With Vandetanib (Zactima(TM)) in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Presented at American Society of Clinical Oncology
11. Semafores SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... 2015  ContraVir Pharmaceuticals, Inc. (NASDAQ: CTRV ... commercialization of targeted antiviral therapies, announced today that it ... Conference, to be held March 8-11, 2015, in ... James Sapirstein , Chief Executive Officer, will provide an ... and will be available to participate in one-on-one meetings ...
(Date:3/5/2015)... March 5, 2015 According to ... by Product (Systems and Disposables), by Type (Invasive, Minimally ... Home and Ambulatory Sites) - Analysis & Global Forecast ... is expected to reach $1,107.4 Million by 2019 from ... at a CAGR of 4.5% during the forecast period. ...
(Date:3/5/2015)... 2015 Ascendis Pharma A/S, a clinical ... technology to address significant unmet medical needs, today ... ENDO 2015 conference being held at the San ... on Thursday, March 5, 2015 during the Pediatric ... PST, and are titled: ...
Breaking Medicine Technology:ContraVir to Present at 27th Annual ROTH Conference 2Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 2Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 3Hemodynamic Monitoring Systems Market Worth $1,107.4 Million by 2019 4Ascendis Pharma to Present at ENDO 2015 2
... Mass., Aug. 17 Block Engineering, a leading ... launch of a family of next-generation, revolutionary spectrometers ... Daniel Cavicchio, chairman of Block Engineering, commented, "This ... and it is the result of a multiyear ...
... 17 Exceptionally high costs.  Long research and development ... regulatory reviews.  Dependence on out-dated information technology options.  It,s ... much valuable information being wasted.   ... development industry have led to the formation of a ...
Cached Medicine Technology:Block Engineering Introduces Family of Quantum Cascade Laser Mid-IR Spectrometers 2RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 2RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 3RedOak Logic's Mission: Transform Pharmaceutical Industry Drug Development 4
(Date:3/5/2015)... Leading nutritional supplement provider Metabolic Nutrition ... and Arnold Fitness EXPO in Columbus, Ohio ... a display booth featuring free samples of its superior ... class-leading fat burner Synedrex. The company will also be ... its top-of-the-line supplements and miniature action figures of its ...
(Date:3/5/2015)... 2015 Think it’s tough to get kids ... get them to brush their teeth. That’s a finding from ... by Delta Dental(1) in conjunction with National Parenting Month in ... getting kids to brush their teeth is one of the ... slightly higher than getting children to eat vegetables regularly (42 ...
(Date:3/5/2015)... 05, 2015 The recent influx of ... promises is alarming, with more and more internet ads ... actual prescription, making it easy for more people to ... their money and endanger their health. The company urges ... prescription online diet pills: , 1.    Where are the products ...
(Date:3/5/2015)... The MTC 5-day Fundamental Implantology Course has been ... variety of dental disciplines, to offer implant placement treatment ... onset we wanted this course to be a truly ... excellence of the lecturers and the sheer energy and ... satisfied our aims." , Unlike large-scale training operations, ...
(Date:3/5/2015)... 05, 2015 Hope For The Warriors® is ... Shoot to be held at Beretta Shooting Grounds (Dover Furnace) ... proceeds from the event will benefit Hope For The Warriors®, ... restoring the family unit, and restoring hope for our service ... our nation’s heroes through a day of clay shooting at ...
Breaking Medicine News(10 mins):Health News:Metabolic Nutrition Exhibiting at 2015 Arnold Sports Festival and Fitness EXPO This Week 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 2Health News:Delta Dental Survey Says Parents Have Harder Time Getting Kids to Brush than to Eat Vegetables 3Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 2Health News:Diet Doc Announces Four Simple Questions that Dieters Must Ask Prior to Purchasing Online Diet Pills 3Health News:MIS Global Training Center (MTC) Launches its Fundamental Implantology Course for Doctors - with a Difference 2Health News:Hope For The Warriors Announces New York Clay Shoot to Benefit Military Families 2
... Researchers have been able to identify neural signatures ... record, measure and analyze both behavior and ... ,Researchers used a specially designed dual-electroencephalogram (EEG) and ... in this study, The Phi Complex as a ...
... to become one of the first major universities in the ... campus. University officials intend to give the Fayetteville campus ... to the policy: the ban is scheduled to go into ... health issue, said Mary Alice Serafini, assistant vice chancellor for ...
... the Ontario Cancer Institute at Princess Margaret Hospital have successfully ... new cancer drug that is triggered by a laser ... ,In a study published today in the Proceedings of ... Scientist - Division of Biophysics and Bioimaging, Joey and Toby ...
... (Childrens Hospital Boston) and colleagues have identified the cancer ... of childhood. ,'Identifying the cancer stem ... in ERMS will likely lead to new insights into ... explains Dr. Zon. ,Rhabdomyosarcoma (RMS) is an ...
... Rsearchers at the University of Florida, found that self-confidence ... more over a lifetime. Believing in yourself ... the study found. ,People with high opinions ... salaries in middle age than their less confident counterparts, ...
... Desperate Housewives actress -Terri Hatcher, has a unique way of using ... ,The actress is following the advice of her Pharmacist ... and sour wine in a bathwater. It is well is a ... good after four to five days. ,"When you're alone ...
Cached Medicine News:Health News:New Brain Neuromarker May Shed Light on Autism and Schizophrenia 2Health News:New Brain Neuromarker May Shed Light on Autism and Schizophrenia 3Health News:University of Arkansas to Ban Tobacco from Its Campus 2Health News:University of Arkansas to Ban Tobacco from Its Campus 3Health News:Scientists Activate New Cancer Drug Using Light and Oxygen 2Health News:Pediatric Cancer Stem Cell Identified 2Health News:Teenage Self Confidence Can Translate Later into Material Wealth 2Health News:Teenage Self Confidence Can Translate Later into Material Wealth 3
7 mm strong curved blade. Round handle....
3 mm diameter roller blade, 15 mm from angle to tip. Round handle....
No. 4. 0.75 mm wide x 5 mm long, lightly curved tip, offset to the left. Hexagonal handle....
Large. 2.5 mm diameter blade. Angled up 45 degrees. Round handle....
Medicine Products: