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PROCRIT(R) (Epoetin Alfa) Data to be Presented at American Society of Hematology Annual Meeting
Date:12/6/2007

iation treatment.

Patients were randomized according to study protocol to "early" or

"standard" intervention groups (n=68 in each group).

-- Abstract: Investigation of Epoetin alfa (EPO) 80,000 Units (U) Every 4

Weeks (Q4W) vs. 40,000 U Every 2 Weeks (Q2W) in Patients with Cancer

Not Receiving Chemotherapy (CT) or Radiation Therapy (RT): Final

Results

Daniel Shasha, M.D., Beth Israel Medical Center, New York, NY

Publication Number 3775

This prospective, randomized, open-label, multi-center pilot study with

100 patients with an active non-myeloid malignancy, baseline hemoglobin

level less than or equal to 11 g/dL, and not receiving or planning to

receive CT or RT during the course of the study, was designed to

investigate two novel dosing regimens in this population. Based on

recent safety concerns from studies with another ESA in cancer patients

not receiving CT or RT, enrollment in this study was stopped prior to

the planned enrollment.

Data on PROCRIT for the Investigational Treatment of Transfusion-Dependent Anemia in MDS Patients

-- Poster: Treatment of MDS Related Transfusion-Dependent Anemia With

Epoetin alfa: A Meta-Analysis Perspective

Suneel Mundle, Ph.D., Ortho Biotech Clinical Affairs, LLC, Bridgewater,

NJ

Presentation: Saturday, December 8, 2007; 5:30pm - 7:30pm; Hall B3 and

B4 in the Georgia World Congress Center (Poster Board Number 625,

Publication Number 1471)

A meta-analysis of data extracted from studies found in PubMed,

American Society of Clinical Oncology (ASCO) and ASH proceedings from

1990 to 2006 in transfusion-dependent MDS patients (n=578) treated with

Epoetin alfa plus or minus granulocyte and granulocyte-macrophage

colony stimulating factors (G/GM-CSF) assessed the efficacy of
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SOURCE Ortho Biotech
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