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PROCRIT(R) (Epoetin Alfa) Data to be Presented at American Society of Hematology Annual Meeting
Date:12/6/2007

nsfused in ESA-treated patients to the number of red blood cell

units that would be transfused if ESAs were discontinued or limited in

the same population.

Data on PROCRIT Investigational Extended Dosing Regimens

-- Abstract: Early vs. Standard Intervention With an Extended Epoetin alfa

(EPO) Dose Regimen of 120,000 Units (U) Every 3 Weeks (Q3W) in

Chemotherapy (CT)-Induced Anemia: Results for Elderly vs. Younger

Patients in a Randomized Clinical Trial

Veena Charu, M.D., Pacific Cancer Medical Center, Inc., Anaheim, CA

Publication Number 3769

A retrospective subset analysis of a prospective, randomized, open-

label, multi-center study compared key efficacy and safety results of

elderly (n=62) and younger (n=73) patients with non-myeloid malignancy.

Patients with chemotherapy planned for greater than or equal to 9 weeks

and baseline hemoglobin greater than or equal to 11 and less than or

equal to 12 grams per deciliter (g/dL) were randomized either to

"early" intervention with Epoetin alfa or to "standard" intervention

with Epoetin alfa when hemoglobin decreased to <11 g/dL.

-- Abstract: Erythroid Response to Epoetin alfa (EPO) 120,000 Units (U)

Every Three Weeks (Q3W) Initiated Early or at a Standard Threshold in

Chemotherapy-Induced Anemia (CIA)

Veena Charu, M.D., Pacific Cancer Medical Center, Inc., Anaheim, CA

Publication Number 3770

A retrospective analysis of observed hematologic profiles from a 16-

week, open-label, randomized study enrolled patients with non-myeloid

malignancy, baseline hemoglobin greater than or equal to 11 and less

than or equal to 12 g/dL, and chemotherapy planned for greater than or

equal to 9 weeks to evaluate whether hemoglobin levels could be

adequately maintained with Q3W Epoetin alfa init
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SOURCE Ortho Biotech
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