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PRISM Pharma Closes $15 million Series C Financing to Advance PRI-724 into Non-oncology Indications
Date:6/12/2013

oncology, yet many patients suffering from fibrosis-related conditions today can only hope at best to slow the increase of fibrosis. Our Series C will allow us to move PRI-724 into the clinic for fibrosis."

PRI-724 is currently in clinical trials for the treatment of solid tumors and leukemia. PRISM has licensed oncology rights to Eisai Co., Ltd. Phase 1 data from a clinical trial of PRI-724 in patients with advanced solid tumors was recently presented at the 49th Annual Meeting of the American Society of Clinical Oncology (ASCO). Data from 18 patients with solid tumors demonstrated PRI-724 had an acceptable safety profile and that its administration led to a decrease in the expression of survivin in circulating tumor cells, a biomarker of on-target drug effect.

About PRI-724
PRI-724 is an antiproliferative small molecule that selectively inhibits the CBP/beta-catenin complex, which modulates the beta-catenin dependent pathway of Wnt signaling. Activation of the Wnt/beta-catenin signaling pathway is observed in various tumor cells and results in proliferation and metastasis. PRI-724 exhibits a selective antiproliferative effect, inhibiting various cancer cell lines in vitro and substantially inhibiting tumor growth in animal studies. PRI-724 is currently in clinical trials in oncology indications, partnered with Eisai Co., Ltd. PRI-724 also has potential to provide therapeutic benefit in non-oncology areas such as fibrosis and clinical trials in that indication are targeted to start in the second half of 2013.

About PRISM Pharma Co., Ltd.
PRISM Pharma Co., Ltd. has developed its platform technology to modulate inter-cellular protein-protein interactions using peptide mimetic small molecules and found various hit compounds including PRI-724. 

This platform is expected to create new drug discovery domains and to meet various unmet medi
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SOURCE PRISM Pharma Co., Ltd.
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