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PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity

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(5) Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE. Combining anchor

and distribution-based methods to derive minimal clinically important

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anemia and fatigue scales. J Pain Symptom Manage 2002 Dec;24(6):547-


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paroxysmal nocturnal hemoglobinuria (PNH) and survival of patients in

Yorkshire [abstract]. Blood. 2006;108(11):985.

(7) Socie G, Mary J Yves, de Gramont A, et al. Paroxysmal nocturnal

haemoglobinuria: long-term follow-up and prognostic factors. Lancet

1996; 348:573-577.

(8) Johnson RJ, Hillmen P. Paroxysmal nocturnal hemoglobinemia: Nature's

gene therapy? J Clin Path: Mol Pathol. 2002;55:145-152.

(9) Wang, et al. Clinical significance of a minor population of

paroxysmal nocturnal hemoglobinuria-type cells in bone marrow failure

syndrome. Blood 2002;100:3897-3902.

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patients with myelodysplastic syndromes. Brit J Haem. 1998; 102:465-


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syndromes and the presence of glycophosphatidyl inositol-anchored

protein-deficient clones. Brit J Haem. 2001;115:1015-1022.

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British Journal of Haematology 2007; 137:3, 181-192.

SOURCE Alexion Pharmaceuticals, Inc.
Copyright©2007 PR Newswire.
All rights reserved

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