Navigation Links
PK Study Comparing Upsher-Smith's Extended-Release Topiramate Formulation (USL255) With Topamax® Published Online In Epilepsia
Date:7/25/2011

MAPLE GROVE, Minn., July 25, 2011 /PRNewswire/ -- In a comparative pharmacokinetic (PK) study, Upsher-Smith Laboratories' USL255, a new, once-daily extended-release formulation of topiramate in development for the management of epilepsy in adults, was shown to be bioequivalent to twice-daily immediate-release topiramate (Topamax®*) in its extent of absorption.  Furthermore, USL255, administered with or without food, demonstrated a slower absorption profile compared with Topamax®.  The more consistent plasma profile of USL255 allows for once-daily dosing with diminished fluctuations in topiramate plasma levels.  The results of this study were published in the online edition of Epilepsia on July 20, 2011.

"In the study, this new topiramate extended-release formulation demonstrated less fluctuation between the peak and trough concentrations than immediate-release topiramate; thereby providing a relatively flat topiramate plasma concentration versus time profile that should allow for once-daily dosing.  Once-daily dosing may simplify topiramate therapy in adult epilepsy patients," said Larry Lambrecht, Pharm.D., first author.  "In theory, reducing fluctuations of plasma concentrations of antiepileptic drugs may also minimize potential concentration-related adverse events."

About the PK StudyThe randomized, open-label, cross-over study had three dosing periods separated by 21 days of washout between treatments. Thirty-six healthy adult volunteers received single doses of USL255 (200 mg) in fasted and fed conditions and two doses of Topamax® (100 mg) administered 12 hours apart. Topiramate plasma samples were analyzed by liquid chromatography with tandem-mass spectroscopy.  

A single dose of USL255 was found to be bioequivalent to Topamax® in its extent of absorption; however, it had a slower extent of absorption as reflected by its later t(max) (time to reach peak plasma con
'/>"/>

SOURCE Upsher-Smith
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study Proves McDavid Ankle Braces Significantly Prevent Injuries
2. PAREXEL Achieves 100th Asian Ethnobridging Study Milestone
3. Isis Initiates Phase 1 Study of ISIS-PTP1BRx to Treat Type 2 Diabetes
4. Study Published in Journal of Vascular Surgery Confirms Superiority of Artegraft BCA to Cuffed ePTFE for Hemodialysis Access
5. DecisionView StudyOptimizer 4.3™ Enhances Market-Leading Enrollment Optimization Solution With Greater Visibility Into Site Performance and Cost Forecasting
6. Upsher-Smith Laboratories Begins Phase III Study of Intranasal Midazolam for Rescue Treatment of Seizure Clusters in Epilepsy Patients
7. Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners
8. Study Confirms that OrbusNeichs Genous™ Stent Effectively Captures Circulating Endothelial Progenitor Cells to Accelerate Re-Endothelialization and Decrease Thrombogenicity
9. Metamark Genetics Announces Cancer Cell Study Highlighting Discovery of Key Molecules that Drive Progression of Malignant Melanoma in Humans
10. Exenatide tQT Study Showed No Prolongation of QT Interval
11. PicoCal Inc. Announces Completion of NSF Funded Research With a Number of New Products, Patents, Publications of Innovative Devices for Topographical Imaging, Thermomechanical Analysis, the Study of Local Mechanical Properties and High Throughput Ap
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 2014 Stryker Orthopaedics, the Official Joint Replacement ... rounding out its debut year of the relationship at ... AZ. This marks the eleventh tournament stop ... the brand has activated on-site with the "Stryker Mobility ... on the importance of joint health.  ...
(Date:10/30/2014)... 30, 2014 WuXi PharmaTech (Cayman) Inc. (NYSE: ... technology platform company serving the pharmaceutical, biotechnology, and medical ... and the United States , ... the Tel Aviv area of ... WuXi,s broad platform of integrated R&D services to local ...
(Date:10/30/2014)... Mass. , Oct. 30, 2014 Boston ... to participate in the 2014 Credit Suisse Annual Healthcare ... Phoenix , AZ.  Dan Brennan , executive ... presentation about the company beginning at approximately 8:00 a.m. ... A live webcast of the presentation and question ...
Breaking Medicine Technology:Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4WuXi AppTec Launches Representative Office in Israel, Forms Strategic Collaboration with Pontifax 2Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2
(Date:10/30/2014)... 30, 2014 USARAD Holdings ... teleradiology and specialty telemedicine solutions provider, including ... its existing teleradiology services at Mission Bend ER, ... expert telemedicine services, to the state-of-the-art, 24/7, freestanding ... result of this innovative partnership, there will be ...
(Date:10/30/2014)... 2014 The human brain is often ... exercised to help maintain better mental health, according to ... Express: Lose Your Memory in 100 Ways’ for just ... sometimes conflicting attitudes to help keep the reader constantly ... reader must decipher the hidden logic within. , “If ...
(Date:10/30/2014)... TX (PRWEB) October 30, 2014 ... released today its 2014 third quarter infection rates ... Texas boasted infection rates of only two percent ... patient satisfaction scores exceeding 98 percent. , “We ... quarter, which included rising satisfaction scores,” said Robert ...
(Date:10/30/2014)... 29, 2014 (HealthDay News) -- When it comes to heart ... men to delay care when they have symptoms that spell ... to the hospital with a more severe or advanced stage ... study author Catherine Kreatsoulas, a Fulbright Scholar and research fellow ... news release from the Heart and Stroke Foundation of Canada. ...
(Date:10/30/2014)... HealthDay Reporter WEDNESDAY, Oct. 29, ... during pregnancy may have effects on genital development in baby ... boys born to moms with greater exposure to a chemical ... the space between the genitals and anus. Anogenital distance is ... exposure to androgens ("male" hormones) during pregnancy. The researchers ...
Breaking Medicine News(10 mins):Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 2Health News:USARAD HOLDINGS INC, SECONDOPINIONS.COM® Pioneers Specialty On-Demand Telemedicine And Second Opinion Service At Houston-Based, Mission Bend Freestanding ER Chain 3Health News:‘Dementia Express’ Offers Contradictory and Sometimes Reverse Thinking, All to Keep its Reader on Their Toes With an Active Mind. 2Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 2Health News:Victory Healthcare Releases Q3 Satisfaction, Infection Rates 3Health News:Women Often Ignore Signs of Heart Trouble 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 2Health News:Plastics' Chemical May Affect Baby Boys' Genital Development 3
... Maharashtra have crashed the efforts of the state to become ... a polio-eradication drive have detected a 9-year old girl with ... affected by the P1 strain of the virus that is ... Chief Minister, Mr Vilasrao Deshmukh, and the Health Minister, Dr ...
... weight seems to have a connection, suggests a new ... to // indicate that babies who weigh less than ... down with Irritable Bowel Syndrome , in comparison to ... documented in the Journal "Gut". ,IBS is annoying, ...
... new study in the October issue of Radiology says ... osteoporotic fractures in women with 75 percent accuracy.// Researchers ... plan accordingly., ,"Approximately 45 percent of women have ... and their spine, leading to uncertainty as to how ...
... cells that may also explain how it evades the immune ... of Illinois at Chicago College of Medicine. ,The ... of Cell Biology. ,Both strains of the herpes ... the mouth, and HSV-2, genital herpes -- can infect the ...
... share vital information with the sincere motive of protecting ... The time is ripe to evolve a cohesive international ... necessitate the sharing of important information regarding influenza virus ... bird flu has taken flight and spread around the ...
... to the scientists from the University of Newcastle, UK, ... disease can eliminate the damage caused in cirrhosis of ... that fibrosis; the scarring linked with cirrhosis is irreversible, ... can be reversed by using Sulphasalazine.,Heavy drinking and obesity ...
Cached Medicine News:Health News:Formula Predicts Osteoporotic Fracture Risk 2Health News:Herpes Infects Cornea, Evades Immune Cells 2
The DSL-05-10-VZM Varicella Zoster IgM Enzyme-Linked Immunosorbent Assay (ELISA) kit provides materials for the determination of IgM-class antibodies to Varicella Zoster Virus in human serum. This as...
Inquire...
The CALBIOTECH, INC. (CBI), Mumps IgM ELISA tests system is an enzyme linked immunosorbent assay (ELISA) for the detection of IgM class antibodies to Mumps in human serum or plasma....
... is comprised of the TEG analyzer and the ... picture of the formation and dissolution of the ... two systems. ,Haemoscope's TEG analyzer is the only ... the reliable and proven model developed by Prof. ...
Medicine Products: