Navigation Links
PK Study Comparing Upsher-Smith's Extended-Release Topiramate Formulation (USL255) With Topamax® Published Online In Epilepsia
Date:7/25/2011

MAPLE GROVE, Minn., July 25, 2011 /PRNewswire/ -- In a comparative pharmacokinetic (PK) study, Upsher-Smith Laboratories' USL255, a new, once-daily extended-release formulation of topiramate in development for the management of epilepsy in adults, was shown to be bioequivalent to twice-daily immediate-release topiramate (Topamax®*) in its extent of absorption.  Furthermore, USL255, administered with or without food, demonstrated a slower absorption profile compared with Topamax®.  The more consistent plasma profile of USL255 allows for once-daily dosing with diminished fluctuations in topiramate plasma levels.  The results of this study were published in the online edition of Epilepsia on July 20, 2011.

"In the study, this new topiramate extended-release formulation demonstrated less fluctuation between the peak and trough concentrations than immediate-release topiramate; thereby providing a relatively flat topiramate plasma concentration versus time profile that should allow for once-daily dosing.  Once-daily dosing may simplify topiramate therapy in adult epilepsy patients," said Larry Lambrecht, Pharm.D., first author.  "In theory, reducing fluctuations of plasma concentrations of antiepileptic drugs may also minimize potential concentration-related adverse events."

About the PK StudyThe randomized, open-label, cross-over study had three dosing periods separated by 21 days of washout between treatments. Thirty-six healthy adult volunteers received single doses of USL255 (200 mg) in fasted and fed conditions and two doses of Topamax® (100 mg) administered 12 hours apart. Topiramate plasma samples were analyzed by liquid chromatography with tandem-mass spectroscopy.  

A single dose of USL255 was found to be bioequivalent to Topamax® in its extent of absorption; however, it had a slower extent of absorption as reflected by its later t(max) (time to reach peak plasma con
'/>"/>

SOURCE Upsher-Smith
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study Proves McDavid Ankle Braces Significantly Prevent Injuries
2. PAREXEL Achieves 100th Asian Ethnobridging Study Milestone
3. Isis Initiates Phase 1 Study of ISIS-PTP1BRx to Treat Type 2 Diabetes
4. Study Published in Journal of Vascular Surgery Confirms Superiority of Artegraft BCA to Cuffed ePTFE for Hemodialysis Access
5. DecisionView StudyOptimizer 4.3™ Enhances Market-Leading Enrollment Optimization Solution With Greater Visibility Into Site Performance and Cost Forecasting
6. Upsher-Smith Laboratories Begins Phase III Study of Intranasal Midazolam for Rescue Treatment of Seizure Clusters in Epilepsy Patients
7. Bayer Study Reveals Gaps in Perception of Veterinary Care Between Vets and Pet Owners
8. Study Confirms that OrbusNeichs Genous™ Stent Effectively Captures Circulating Endothelial Progenitor Cells to Accelerate Re-Endothelialization and Decrease Thrombogenicity
9. Metamark Genetics Announces Cancer Cell Study Highlighting Discovery of Key Molecules that Drive Progression of Malignant Melanoma in Humans
10. Exenatide tQT Study Showed No Prolongation of QT Interval
11. PicoCal Inc. Announces Completion of NSF Funded Research With a Number of New Products, Patents, Publications of Innovative Devices for Topographical Imaging, Thermomechanical Analysis, the Study of Local Mechanical Properties and High Throughput Ap
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 2014 According to the ... (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave), Application (General ... Global Forecasts to 2019", published by MarketsandMarkets, studies the ... of 2014 to 2019. The market is expected ... of 9.6% from 2014 to 2019. ...
(Date:9/23/2014)... Ill. , Sept. 23, 2014  Medela announced ... Atlanta Biomedical Company (ABC), assigning Medela as the exclusive ... now known as the Medela Enteral Feeding Pump. Through ... to help NICU parents and healthcare professionals by offering ... The Medela Enteral Feeding Pump is integral to the ...
(Date:9/23/2014)... , Sept. 23, 2014 A case report ... a SynCardia temporary Total Artificial Heart into a patient ... ventricles were reversed, along with other abnormalities. ... modifying the SynCardia Total Artificial Heart to treat a ... report and video in the Journal of Visualized Experiments ...
Breaking Medicine Technology:Ablation Technologies Market Worth $3.81 Billion by 2019 2Ablation Technologies Market Worth $3.81 Billion by 2019 3Ablation Technologies Market Worth $3.81 Billion by 2019 4Medela Enters Exclusive Enteral Feeding Pump Agreement with Atlanta Biomedical Company 21st Use of the SynCardia Total Artificial Heart in a 17-Year-Old Congenital Heart Disease Patient at Pediatric Hospital 21st Use of the SynCardia Total Artificial Heart in a 17-Year-Old Congenital Heart Disease Patient at Pediatric Hospital 31st Use of the SynCardia Total Artificial Heart in a 17-Year-Old Congenital Heart Disease Patient at Pediatric Hospital 4
... 10, 2011 In the year since a devastating earthquake ... and around the world have launched and supported projects to ... the New Year began, Rotary clubs started a $200,000 initiative ... outbreak of the waterborne disease. Rotary clubs worldwide ...
... Jan. 10, 2011 CoreLab Partners, Inc , ... Inc and Medifacts International, has launched a new advanced ... are pleased to announce the release of our proprietary ... development continuum by offering sponsors advanced technologies and integrated ...
Cached Medicine Technology:Rotary Clubs Remain Committed to Rebuilding Quake-Ravaged Haiti 2Rotary Clubs Remain Committed to Rebuilding Quake-Ravaged Haiti 3CoreLab Partners Launches Advanced Imaging Application 2CoreLab Partners Launches Advanced Imaging Application 3
(Date:9/23/2014)... (PRWEB) September 23, 2014 What ... The National Quality Forum (NQF) released a ... http://www.qualityforum.org/WorkArea/linkit.aspx?LinkIdentifier=id&ItemID=77687 ), and an infographic ( http://bit.ly/1tX3lzA ) ... cost of healthcare, how patients define affordability, and ... to get the best possible healthcare at the ...
(Date:9/23/2014)... NY (PRWEB) September 23, 2014 ... on Manhattan’s Upper West Side that embodies the ... Inhabiting Eden: Christians, Scripture and the Ecological Crisis, ... A. B. Rhodes Professor Emerita of Old Testament ... Bible for ancient wisdom that lends insight into ...
(Date:9/23/2014)... Sept. 23, 2014 (HealthDay News) -- The number ... prescription drugs is growing, so doctors need to ... and Drug Administration warned Tuesday. In a ... widespread that it has launched a program to ... administrators about proper drug purchasing procedures. The program ...
(Date:9/23/2014)... are already obese as teenagers could grow up to ... of normal weight. So says Petter Lundborg of Lund ... of Linneas University and Lund University, all in Sweden. ... Kingdom and the United States, and the results are ... The researchers analyzed large-scale data of 145,193 Swedish-born brothers ...
(Date:9/23/2014)... Both patients and healthcare professionals believe diagnosis of ... greatly outweighs the potential disadvantages of subsequent radiologic ... according to a new study published in the ... , Diagnostic tests used for cancer screening programs ... for colorectal cancer with CT colonography, abdominal and ...
Breaking Medicine News(10 mins):Health News:Finding Affordable Care: Asking the Right Question is Key 2Health News:Inhabiting Eden: Christians, Scripture, and the Ecological Crisis – Public Lecture to Discuss Faith-Based Environmentalism 2Health News:Note to young men: Fat doesn't pay 2Health News:Patients accept false-positives to achieve diagnostic sensitivity 2Health News:Patients accept false-positives to achieve diagnostic sensitivity 3
... of New Molecular Entities Drops to Historic Low ... Face Increasing Competition from ... Scientific business of Thomson,Reuters today announced the availability ... Factbook, an indispensable reference,and business planning tool for ...
... welcome to out-of-state intended parents, SAN RAMON, ... decision to allow gay couples to marry strengthens ... Bay Area (RSC), one of,the state,s leading fertility ... "California,s legalization of same-sex marriage supports RSC,s,long-held ...
... for Immigration and Naturalization ready at Passport ... ... New vaccine requirements will affect,anyone who is applying for an ... status for permanent residence. Applicants,must show proof of vaccinations against vaccine-preventable ...
... Excessive IMP-3, not found in harmless moles, may be key ... produces high levels of a protein called IMP-3, which is ... researchers report. , They said the finding may offer doctors ... type of skin cancer -- from benign moles that look ...
... The American Heart,Association announces the call for ... association,s highest honor for health and science,reporting., ... and honor the career,achievements of science, health and ... in the fight against heart disease and,stroke. This ...
... County,Place Matters Team will host a three-day meeting July ... that lead to poor health outcomes,in individuals from low-income ... cities and counties will attend. Place Matters,is a national ... Health Policy Institute and is funded by the W. ...
Cached Medicine News:Health News:Thomson Reuters Publishes CMR International's 2008 Pharmaceutical R&D Factbook, Now Available for the First Time Online 2Health News:California Supreme Court Gay-Marriage Ruling Reinforces Top Bay Area Fertility Specialists' Support for Same-Sex Couples 2Health News:USCIS Tightens Vaccination Requirements 2Health News:Protein Gives Doctors New Tool to Detect Melanoma 2Health News:Alameda County Hosts National Initiative to Reduce Health Disparities 2
... Retinol binding Proetin (RBP) is small ... a complex with pre-albumin in blood but ... has been deliverd to the target cells. ... at the glomerulus and catabolized in the,renal ...
... is an enzyme immunoassay (EIA) kit for ... of the subclass of Anti-Neutrophil Cytoplasmic Antibodies ... as an aid in the diagnosis of ... associated with vasculitic disorders and glomerulonephritis (GN). ...
Anti-MPO ANCA EIA Auto-Immune Markers 013-MPO-96 Myeloperoxidase...
GBM -Ab EIA Auto-Immune Markers 013-GBM-96 Glomerular Basement Membrane...
Medicine Products: