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PARI's eFlow Delivers Alnylam RNAi Therapeutic in Phase II Study
Date:4/17/2008

MONTEREY, Calif., April 17 /PRNewswire/ -- An optimized PARI eFlow platform nebulizer will be delivering Alnylam's ALN-RSV01 in a Phase II human clinical trial that has begun enrolling patients. ALN-RSV01 is a RNAi therapeutic being developed as a treatment for respiratory syncytial virus (RSV) infection, the leading cause of pediatric hospitalization in the U.S. and a prevalent infection in immune-compromised adults. RSV currently does not have a viable treatment option.

"The progression into Phase II clinical trials with Alnylam's therapeutic is significant as it is the first RNAi program in clinical trials using inhalation. We are seeing a number of companies turn to advanced nebulization with our eFlow platform, because the flexibility allows the development of new respiratory therapies that are delivered to the lungs in a faster, more effective manner," said Geoff A. Hunziker, President of eFlow LLC.

Respiratory syncytial virus (RSV) is a highly contagious virus that causes infections in the upper and lower respiratory tract associated with predictable seasonal outbreaks worldwide. RSV infection is the most common cause for infant hospitalization (more than 100,000 hospitalizations annually in the U.S.), and the virus is a significant pathogen in the elderly. The RNAi therapeutic agent ALN-RSV01 is a small interfering ribonucleic acid (siRNA) targeting the messenger RNA of the RSV N gene to prevent viral replication. To deliver ALN-RSV01 to the site of infection, the RNA therapeutic is being administered as an aerosol in a highly efficient pulmonary delivery system, an optimized eFlow platform nebulizer, with high drug output, optimized droplet size, and low residual drug loss.

For more information on the Phase II study, visit http://www.alnylam.com.

About eFlow

eFlow, an electronic, portable nebulizer platform, enables extremely efficient aerosolization of liquid medic
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SOURCE PARI Pharma
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