Navigation Links
PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans
Date:6/2/2009

nts had double lung transplants and seven patients had single lung transplants. Patients were given a single dose application of 10mg or 20mg of liposomal L-CsA, which was well tolerated. Deposition data showed a peripheral lung deposition of 2mg for a nominal, 10mg dose that was nebulized in less than ten minutes. Once daily administration of a nominal dose of 10mg L-CsA with an Investigational eFlow Nebulizer System would give approximately 14 mg L-CsA/week. Mean values for C(max) and AUC(0-inf) were up to 20ng/mL and 110 h ng/mL, respectively. These results are significantly lower compared to oral therapy. In comparison, oral CsA (Neoral(R)) therapy in lung transplant patients leads to highly variable C(max) and AUC(0-12h) values of approximately 1,800ng/mL and 8,000 h ng/mL, respectively when given twice daily in a dose of up to 250mg [Knoop 2003]. L-CsA's favorable and significantly lower pharmacokinetic values were obtained for both dose strengths tested. Phase Ib study results for L-CsA are published in the June 2009 volume of the Journal of Aerosol Medicine and Pulmonary Drug Delivery [Behr et al., Vol. 22, No. 2, p.121-129].

About PARI Pharma's Inhaled L-CsA Formulation

PARI Pharma's L-CsA is a low-dose, inhaled, liposomal cyclosporine A formulation that aims to improve the pharmacological profile, the highly variable bioavailability, and the severe side effects of oral CsA. (Severe side effects of oral CsA include kidney and brain damage, cancer, and vulnerability to infections.) L-CsA is an investigational, proprietary, liposomal formulation of 10mg CsA/2.5mL for inhalation delivery via a customized Investigational eFlow Nebulizer System. The L-CsA formulation is based on an artificial lung surfactant carrier. It is free of any irritating organic solvents and consists of unilamellar liposomes of about 100nm. The unilamellar liposomes are obtained via a high-pressure homogenization process using standard pharmaceutical
'/>"/>

SOURCE PARI Pharma
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)
2. Arena Pharmaceuticals Announces the Presentation of Lorcaserin Phase 3 BLOOM Data at the American Diabetes Associations 69th Scientific Sessions
3. Neurobiological Technologies Partner, Celtic Pharma, Announces Results of XERECEPT(R) Phase 3 Clinical Program
4. Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
5. Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer
6. Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401s Activity in the Treatment of Advanced Metastatic Renal Cell Cancer
7. Catalyst Pharmaceutical Partners Announces Top-Line Results of CPP-109 Phase II Trial for Cocaine Addiction
8. Poniard Pharmaceuticals Announces Progression-Free Survival Data From Phase 2 Clinical Trial of Picoplatin in Metastatic Colorectal Cancer
9. BioCis Pharma Starts a Phase I Clinical Trial With a New Cancer Drug
10. Kinex Pharmaceuticals To Present at ASCO 2009 Annual Meeting
11. TRACON Pharmaceuticals Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)...  CVS Caremark Corporation (NYSE: CVS ) ... 5, 2014, at 8:30 a.m. (EDT) with analysts and ... An audio webcast of the conference call ... of the CVS Caremark website for all interested parties.  ... webcast will be archived and available on the web ...
(Date:7/25/2014)... Group Inc (OTC: SLNX) is pleased to announce that ... the Letter of Intent issued on July 11, 2014 ... Charles R. Shirley , Managing Director ... David Pecoraro and Buzznbrewz.com join SLNX,s team.  ... and developed a tremendous network of contacts who have ...
(Date:7/25/2014)... 25, 2014  AMETEK, Inc. (NYSE: AME ... Goos as Vice President and General Manager, Engineered ... (EMIP) Division. "I am pleased that Kurt ... business development experience, especially in the medical device industry, ... the continued growth and success of our medical components ...
Breaking Medicine Technology:Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2
... QPS, LLC, a leading full-service GLP/GCP-compliant contract research ... research and development, announced the acquisition of a majority ... the biotechnology company Genovate, Inc, is a full service ... retain a minority interest in Qualitix, which will be ...
... 2011 Minnesota has long been known as a leader ... report released today from Children,s Hospitals and Clinics of Minnesota ... 2009 National Immunization Survey (NIS), Minnesota has dropped 13 spots ... 20th place in 2009 – for vaccination coverage rates for ...
Cached Medicine Technology:QPS Expands Clinical Trial Services with Acquisition of Qualitix 2QPS Expands Clinical Trial Services with Acquisition of Qualitix 3New Report from Children's Hospitals and Clinics Shows Vaccination Rates Declining among Minnesota Children 2New Report from Children's Hospitals and Clinics Shows Vaccination Rates Declining among Minnesota Children 3New Report from Children's Hospitals and Clinics Shows Vaccination Rates Declining among Minnesota Children 4
(Date:7/27/2014)... (HEV) transmission by blood components indicates that about 1 ... plasma. The findings, published in The Lancet , ... cells, platelets, and fresh frozen plasma) are likely to ... study retrospectively screened 225 000 individual blood donations collected ... 2013 for HEV RNA. 79 donors were found to ...
(Date:7/27/2014)... (PRWEB) July 27, 2014 The inaugural ... Latinos demonstrate their passion for protecting our environment and ... in the Southwest, will go on hiking or camping ... to show their support for permanently protecting our land, ... sharing the Latino community’s perspective on the environment like ...
(Date:7/27/2014)... North American security and surveillance radar market under defense ... it is expected to reach $2030 million by 2019 ... factors that influence a country’s expenditure on radars. It ... expenditure. The report also throws light on the leading ... overview of the companies, it focuses on their financial ...
(Date:7/27/2014)... 1-Butene is a colorless, combustible gas with ... can be manufactured either through the separation from crude ... Linear alpha olefin (alkene) 1-Butene is a versatile chemical ... important chemicals such as linear light density polyethylene (LLDP), ... 1-Butene market is extremely competitive. The market has several ...
(Date:7/27/2014)... (PRWEB) July 27, 2014 Although ... Australia is restricted to two companies, heavy government ... IBISWorld industry analyst Spencer Little, “Demand for cigarettes ... to rising health concerns, frequent anti-smoking campaigns, increasing ... industry revenue is estimated to fall at a ...
Breaking Medicine News(10 mins):Health News:The Lancet: 1 in 3000 blood donors in England infected with hepatitis E 2Health News:Latino Conservation Action Week Launches, Highlights Latinos’ Dedication to Protecting Our Environment 2Health News:Latino Conservation Action Week Launches, Highlights Latinos’ Dedication to Protecting Our Environment 3Health News:North America Security and Surveillance Radar Market is Expected to Reach $2030 million in 2019 - New Report by MicroMarket Monitor 2Health News:North America Security and Surveillance Radar Market is Expected to Reach $2030 million in 2019 - New Report by MicroMarket Monitor 3Health News:North America Security and Surveillance Radar Market is Expected to Reach $2030 million in 2019 - New Report by MicroMarket Monitor 4Health News:North America Security and Surveillance Radar Market is Expected to Reach $2030 million in 2019 - New Report by MicroMarket Monitor 5Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 2Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 3Health News:North America 1-Butene Market is Expected to Reach $794 million in 2018 - New Report by MicroMarket Monitor 4Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Cigarette and Tobacco Product Manufacturing in Australia Industry Market Research Report Now Updated by IBISWorld 4
... 11 a.m. in Richmond RICHMOND, Va., March 3 ... press conference on March 5 in Richmond to call on ... Virginia Congressional Delegation to support legislation that would grant the ... The House Energy and Commerce Committee is scheduled to ...
... Consuming two or more drinks per day could ... 22 percent, according to data published in Cancer ... American Association for Cancer Research. , "Our findings ... to no more than two alcoholic beverages per day ...
... provides insight into how a short burst in nitrite can ... stress and assaults such as heart attacks. In this study, ... University School of Medicine have demonstrated for the first time ... are sufficient to have a lasting impact on the heart ...
... that multiple types of child maltreatment are robust risk ... multi-year study that explored the influence of social environment ... research, which appears in the current issue of ... five or more alcoholic drinks on a single occasion ...
... AIRM ) will report financial results for the ... the market on Tuesday, March 10, 2009. The Company ... at 4:15 p.m. Eastern to discuss these results. Interested ... or (706) 643-8826 (international) or by accessing the web cast ...
... children are prone to, study suggests , , TUESDAY, March ... inattentive could be susceptible to gambling by the time ... Impulsiveness can lead to many problems, such as dropping ... and now gambling has been added to the list, ...
Cached Medicine News:Health News:Virginia Faith Leaders Call on Sens. Webb & Warner to Support Legislation to Protect Kids From Tobacco 2Health News:New study shows how spikes in nitrite can have 2Health News:New study shows how spikes in nitrite can have 3Health News:How multiple childhood maltreatments lead to greater adolescent binge drinking 2Health News:How multiple childhood maltreatments lead to greater adolescent binge drinking 3Health News:Impulsive Kindergartners May Turn to Gambling 2Health News:Impulsive Kindergartners May Turn to Gambling 3
... first manufacturer to offer through-the-lens (TTL) ... These next generation loupes feature extremely ... design, and are multi-coated lens for ... SheerVision's proprietary SureFit system - you ...
Easy pull-on garment's feature Rainey's exclusive Non-Slip Dome™design and adjustable Velcro© closure at neck for optimal comfort and support. Choose covered or non covered ear design....
Facial Wrap...
CDIs Chin Support Bandage is ideal for Submental Liposuction, Chin Implants and all other facial procedures requiring support. Adjustable Velcro® top and posterior band secures placement....
Medicine Products: