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PAREXEL Advances Early Phase CNS Research Capabilities With Leading Medical Imaging Technology
Date:11/22/2011

dvanced technologies in the assessment of CNS diseases, such as Alzheimer's disease, other neurodegenerative disorders, such as Parkinson's and Multiple Sclerosis, as well as in psychiatric disorders and in pain research. Our goals are to diagnose and treat ahead of significant brain and neurological damage, and open the door for disease course modifying drugs, including primary and secondary prevention strategies."

The research-enhanced fMRI technology provides greater speed, advanced image detail, and more scanning flexibility.  Enabled with 3 Tesla (3T) power—a unit of measurement quantifying the strength of the magnetic field—PAREXEL can conduct scans to evaluate regions of interest with more anatomical detail, and detect smaller drug induced changes in brain function. With this capability, image quality is increased significantly, and image acquisition times are shortened. This technology allows PAREXEL to not only assess regions of activity but also functional connectivity among neurological networks. Additionally, early phase CNS experts can determine which regions are activated or deactivated by certain drug effects. This more sensitive measurement capability supports complex clinical studies focused on disease course modification techniques and improved symptomatic therapies earlier in the progression of an illness. The approach can be a sensitive pharmacodynamic tool to demonstrate proof of mechanism, especially when used in conjunction with other corroborative CNS biomarkers.

With extensive, relevant experience and in-depth expertise, PAREXEL assists clients with ever more complex early-phase trial design and execution, as well as efficient delivery of better, faster go/no-go decisions from First-in-Human (FIH) through Proof-of-Concept. The Company's hospital-based units in the U.S., Europe, and South Africa, as well as a network of alliance sites, provide clients with excellent patient access specific to key therapeutic a
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SOURCE PAREXEL International Corporation
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