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Oxford BioMedica Announces Ocular Programme Update
Date:6/22/2011

OXFORD, England, June 22, 2011 /PRNewswire/ --


 

-RetinoStat® Progress in Phase I Study in Wet Age-Related Macular Degeneration

 

Oxford BioMedica plc ("Oxford BioMedica" or "the Company") (LSE: OXB), a leading gene therapy company, today announces that the first dose level of RetinoStat® is safe and well-tolerated at one month following treatment.  RetinoStat® is a novel gene-based treatment for neovascular "wet" age-related macular degeneration (AMD), designed and developed by Oxford BioMedica using the Company's proprietary LentiVector® gene delivery technology.  It is the lead programme of the ocular agreement the Company signed with Sanofi (EURONEXT: SAN and NYSE: SNY) in April 2009.

The on-going Phase I study will enrol 18 patients with wet AMD at the Wilmer Eye Institute at Johns Hopkins, Baltimore (USA).  Led by Professor Peter Campochiaro, the study will evaluate three dose levels and assess safety, aspects of visual acuity and ocular physiology.  Three patients received the first dose level of RetinoStat® and one-month results have been assessed by the study's independent Data Safety Monitoring Board (DSMB).  First results from the study are expected to be announced in H1 2012.

Highlights of first patient cohort at one month (dose level 1)

  • Favourable safety profile with no serious adverse events related to RetinoStat® or its method  of administration
  • No signs of inflammation in the eye
  • DSMB support received to proceed to dose level 2 in the next patient cohort

John Dawson, Chief Executive Officer of Oxford BioMedica, said: "Thi
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SOURCE Oxford Biomedica Plc
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