Navigation Links
Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy
Date:4/14/2009

Trial to Evaluate Safety of CCL2-LPM for Inflammatory Kidney Disease

SAN FRANCISCO, April 14 /PRNewswire/ -- Osprey Pharmaceuticals U.S.A., Inc. announced today that patient dosing has commenced in a Phase Ib clinical trial of the company's lead compound, CCL2-LPM, for the treatment of IgA nephropathy, an inflammatory kidney disease. Osprey Pharmaceuticals U.S.A. is developing novel chemokine-enzyme fusion protein therapeutics, known as Leukocyte Population Modulators (LPMs), for the treatment of inflammatory and autoimmune diseases. CCL2-LPM selectively targets activated leukocytes expressing the chemokine receptor CCR2 that are responsible for initiating and maintaining a variety of inflammatory conditions.

The Phase Ib open-label, dose-escalating study will enroll up to 30 patients diagnosed with IgA nephropathy at clinical sites in Canada. The trial design utilizes a continuous reassessment method to evaluate safety of CCL2-LPM and to establish a maximum-tolerated dose. Secondary endpoints for the Phase Ib clinical trial include an assessment of pharmacokinetics and biomarkers of disease associated with the mechanism of action of CCL2-LPM.

"We are pleased to advance the first of our LPM compounds designed to target and neutralize chemokine-mediated inflammation into clinical trials. CCL2-LPM has shown a favorable pharmaceutical profile, demonstrating efficacy at low doses in models of glomerulonephritis, as well as tolerability at relatively high doses in preclinical toxicology testing," said Barbara Finck, M.D, Senior Vice President of Research and Development and Chief Medical Officer for Osprey Pharmaceuticals U.S.A., Inc. "We are hopeful that the Phase Ib clinical trial of CCL2-LPM will provide us with indications of the compound's biologic activity in addition to establishing safety. Initial results from the Phase Ib study are expected later this year."

CCL2-LPM is the most advan
'/>"/>

SOURCE Osprey Pharmaceuticals U.S.A., Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Optimer Pharmaceuticals Receives Production Patent for Lead Product Candidate Fidaxomicin
2. Raptor Pharmaceuticals Appoints Dr. Patrice P. Rioux as Chief Medical Officer
3. Strativa Pharmaceuticals Provides Product Pipeline Update
4. Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009
5. Arena Pharmaceuticals to Host Conference Call and Webcast on Monday, March 30, 2009 to Discuss Lorcaserin Pivotal Phase 3 Obesity Trial Results
6. Oramed Pharmaceuticals to Present Oral Insulin Phase 2A Trial Results at the Upcoming Annual Meeting of the ADA (June 5-9, New Orleans, LA)
7. XTL Biopharmaceuticals Announces the Acquisition of the Use Patent on Recombinant Erythropoietin (rHuEPO) for the Treatment of Multiple Myeloma
8. Poniard Pharmaceuticals Reports Fourth Quarter and Year End 2008 Financial Results and Provides a Corporate Update
9. Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-211, Potent Small Molecule for Treatment of Schizophrenia.
10. Quark Pharmaceuticals Presents at Asia TIDES Conference
11. NovaBay Pharmaceuticals Announces Lead Anti-infective Product Candidate, NVC-422, Shown to be Effective in Treating Topical Fungal Infection
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... TAMPA, Fla. , May 29, 2015  Excite ... , in 2007.  Over the years, Excite Medical, under ... to be an enduring company, with a solid track ... loyal and growing client and distributor base.  ... The success of Excite Medical has been possible, in ...
(Date:5/29/2015)... , May 29, 2015 A six-hour certification program ... being presented at the Cannabis World Congress & Business ... New York, NY .  Taking place on Wednesday, June ... day of education at the leading event on the East ... Led by Clover Leaf University, the first cannabis university ...
(Date:5/29/2015)... , May 29, 2015 Eli Lilly ... Goldman Sachs 36th Annual Global Healthcare Conference on Tuesday, ... president and president, Elanco Animal Health, will participate in ... A live audio webcast will be ... investor website at http://investor.lilly.com/events.cfm . A replay of ...
Breaking Medicine Technology:Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 2Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 3Cannabis Business Certification and Career Workshops Presented at New York Trade Show & Conference 4Lilly to Participate in Goldman Sachs Global Healthcare Conference 2
(Date:5/29/2015)... May 29, 2015 John A. Gennaro, ... Cincinnati , The Department of Veterans Affairs (VA) is ... as the new director of the Cincinnati VA Medical ... to more than 43,000 unique Veterans annually and an ... 2,000 staff, CVAMC is a two-division campus located in ...
(Date:5/29/2015)... The science of Follicular Unit Extraction (FUE) ... efficient methods of FUE hair transplantation have increased the amount ... most cutting edge hair transplant methods being used to great ... extracting hair from the beard to the scalp. , Most ... male pattern baldness. Beard hair has a life cycle, ...
(Date:5/29/2015)... May 29, 2015 On May 21, 2015, ... be When You Get Botox ?” reported on the ... Google. Elle partnered with Google to determine these results and ... searched question in California, for example, is how to ... common search query is what's the appropriate age to start ...
(Date:5/29/2015)... To compile the list, the Becker's Hospital Review ... awards for clinical and general excellence. The team also ... them in terms of overall excellence, and those systems ... Great Health Systems to Know 2015 list includes the ... , Advocate Health Care (Downers Grove, Ill.) , Asante ...
(Date:5/29/2015)... Diego, California (PRWEB) May 29, 2015 A ... Core” and have joined the national effort to teach this ... parents in the U.S. have been “sickened” by the recent ... However, love it or hate it, Common Core is now ... District of Columbia. Parents are now seeking ways to ...
Breaking Medicine News(10 mins):Health News:VA Healthcare System of Ohio Network Announces New Medical Center Director 2Health News:Beard to Scalp Hair Transplant: Newest Advance in Hair Transplant Technology 2Health News:Botox, Wrinkles and Double Chins: The Most-Asked Beauty Problems According to Google 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 2Health News:Becker's Hospital Review Names 50 Great Health Systems to Know 3Health News:Doctors Discover a Cure for the Common Core 2
... , , , ... The Agence de Medecine Preventive (AMP),has received a three-year grant of ... create a consortium supporting cholera prevention and control,in Africa . ... Network (AFENET) will be the core,members of the consortium, which will ...
... ... EKG, a portable PC-based EKG/ECG system that provides powerful data and analysis functions. , ... (Vocus) January 14, 2010 -- DRE, ... DRE Velocity EKG , a 12-channel PC-based EKG system that provides impressive cost savings ...
... AMD Global Telemedicine ... , ... 14, 2010 -- AMD Global Telemedicine Inc. (AMD) today announced that Texas Tech ... telemedicine program to an additional 30 sites located in rural parts of the state of ...
... ... work in devastated Haiti, Good Neighbor Insurance is trying to contact members of ... what they will need from the surge of help that will come from ... be able to see that they have the proper overseas health insurance for ...
... ... today that NebDoctors of Nevada, provider of Nebulizers (pediatric respiratory products), has ... , ... (PRWEB) January 15, 2010 -- MessageBroadcast announced today ...
... Jan. 13 A renewed discussion of salt intake in ... America to focus efforts on sodium reduction for health benefits. ... is leading a partnership of cities and national health organizations ... restaurant foods." (" New York leads plan to cut salt ...
Cached Medicine News:Health News:AMP Receives Grant From the Bill & Melinda Gates Foundation to Support Cholera Surveillance in Africa 2Health News:AMP Receives Grant From the Bill & Melinda Gates Foundation to Support Cholera Surveillance in Africa 3Health News:Cost-effective PC-based EKG Now Available from DRE 2Health News:Cost-effective PC-based EKG Now Available from DRE 3Health News:AMD Global Telemedicine Inc. and Texas Tech University Health Sciences Center Bring High-Tech Health Care to Children of Texas 2Health News:AMD Global Telemedicine Inc. and Texas Tech University Health Sciences Center Bring High-Tech Health Care to Children of Texas 3Health News:Relief Organizations Scramble to Assess Damage in Haiti 2Health News:Relief Organizations Scramble to Assess Damage in Haiti 3Health News:MessageBroadcast Launches Automated Medicare Survey System for NebDoctors of Nevada 2Health News:MessageBroadcast Launches Automated Medicare Survey System for NebDoctors of Nevada 3Health News:New Year, Renewed Focus on Sodium Consumption 2Health News:New Year, Renewed Focus on Sodium Consumption 3
... TOPCON ALE-3600 and ALE-3600PC ... perfectly fit lenses to ... with the convenience of ... lens edgers are particularly ...
...
Inquire...
... The TOPCON OM-4 Ophthalmometer ... compactly designed and easy ... providing precise objective measurements ... of curvature plus accurate ...
Medicine Products: