Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficil...(lostridium difficile Spores researchers...),Health

Date:9/19/2007

lostridium difficile Spores," researchers compared the activity of oritavancin, metronidazole and vancomycin against epidemic C. difficile spores using spiral gradient endpoint, agar-based culture, and phase contrast microscopy. Using these three different experimental methods, results from the study indicated that oritavancin interacts with and disrupts the transition from dormant C. difficile spores to vegetative cells to a greater extent than existing therapeutic antimicrobial agents. In addition, there was a marked difference in oritavancin activity against C. difficile spores versus vegetative cells (5- to 13-fold lower MICs against the spores); Targanta believes that such a phenomenon has not been reported previously.

About Oritavancin

Oritavancin is a novel semi-synthetic lipoglycopeptide antibiotic candidate with potent bactericidal (killing) activity against a broad spectrum of gram-positive bacteria. The product candidate has been tested in over 1500 patients and has completed two Phase 3 studies for the treatment of complicated skin and skin structure infections (cSSSI) in which the primary endpoints were met. Targanta believes oritavancin's properties may give it distinct advantages over currently marketed therapies and expects to submit a New Drug Application to the U.S. Food and Drug Administration in the first quarter of 2008 seeking to commercialize oritavancin for the treatment of cSSSI.

About Targanta Therapeutics

Targanta Therapeutics Corporation is a privately held biopharmaceutical company focused on developing and commercializing innovative antibiotics to treat serious infections in the hospital and other institutional settings. The Company's pipeline includes oritavancin, a semi-synthetic lipoglycopeptide antibiotic, for which Targanta intends to seek U.S. regulatory approval in early 2008, as well as a number of antibacterial agents in pre-clinical development. The company has operations in Cambridge, MA, Indianapolis,
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SOURCE Targanta Therapeutics Corporation Copyright©2007 PR Newswire. All rights reserved

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