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Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria
Date:9/19/2007

CHICAGO, Sept. 19 /PRNewswire/ -- Targanta Therapeutics Corporation today released detailed data from completed studies comparing the in vitro activity of its lead antibiotic drug candidate, oritavancin, to that of other antibiotics against a variety of susceptible and resistant strains of gram- positive bacteria. Results are being presented today at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) taking place in Chicago, IL. All posters highlighted below are being presented at 12:15 pm CDT.

Poster E-1617 is entitled "In Vitro Activity Profile of Oritavancin (ORI) Against Resistant Staphylococcal Populations From a Recent Surveillance Initiative." In this study, researchers examined clinical isolates of Staphylococcus aureus (n=5,008) and coagulase-negative staphylococci (n=862) collected in 2005-2006 from hospital sites in the U.S., Europe and Israel. Oritavancin was active against all staphylococcal isolates, including those with specific resistance phenotypes and including multi-drug resistant S. aureus, which were resistant to three or more of the following agents: ciprofloxacin, clindamycin, erythromycin, gentamicin, oxacillin, quinupristin- dalfopristin, trimethoprim-sulfa, vancomycin, daptomycin, and linezolid. Results from this study demonstrated that oritavancin had potent in vitro activity against a wide spectrum of staphylococci likely to be encountered in a variety of clinical settings.

Poster E-1613, entitled "In Vitro Activity Profile of Oritavancin (ORI) Against Organisms Demonstrating Key Resistance Profiles to Other Antimicrobial Agents," compared the activity of oritavancin to vancomycin and teicoplanin against a diverse collection of staphylococci and enterococci, including strains with elevated MICs to linezolid, daptomycin, and/or vancomycin, as well as strains of streptococci. Bacterial isolates included S. aureus (n=35), coagulase-negative staphylococci (n=21), Enterococcus faecalis (
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SOURCE Targanta Therapeutics Corporation
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