Navigation Links
Orion Genomics Enters Discovery Collaboration and License Agreement to Advance Personalized Diagnostics

ST. LOUIS, Oct. 12 /PRNewswire/ -- Orion Genomics today announced that it has entered into a multi-year collaboration and license agreement with the molecular diagnostics unit of Novartis Pharma AG. Under the collaboration, the parties seek to discover novel epigenetic biomarkers, and both parties have rights to independently develop and commercialize diagnostic products in their respective fields. Under the terms of the agreement, Orion Genomics also grants Novartis non-exclusive world-wide rights to its proprietary MethylScreen clinical assay technology. Financial terms were not disclosed.

"Epigenetic changes can play a key role in certain disease biology, and could lead to the development of important new diagnostic tools," said Nathan D. Lakey, President and CEO of Orion Genomics. "Ultimately, our collaboration with Novartis Molecular Diagnostics aims to support the development of innovative tests which we hope will provide physicians and patients with better information to guide treatment decisions."

The collaboration will leverage Orion Genomics' MethylScope® Technology to build high-resolution genome-wide DNA methylation maps for the discovery of epigenetic biomarkers in multiple disease fields. Novartis also obtains a non-exclusive license to MethylScreen® Technology, Orion's PCR-based clinical assay platform that quantitatively detects epigenetic biomarkers in patient samples. Under the agreement, Orion and Novartis intend to develop and commercialize promising diagnostic products that address various stages of disease. Resulting diagnostic tests could lead to advances in personalized medicine, potentially helping doctors optimize the treatment of patients.

"Science is revealing that epigenetics is a potent driver of disease biology and therapeutic response and a potential linchpin in the efforts to make personalized medicine a reality," said Howard McLeod, Professor of Medicine and Pharmacy and Director of the University of North Carolina Institute for Individualized Therapy. "As we consider how to optimize the use of the healthcare dollar, leveraging personalized medicine tools such as epigenetics to do a better job of matching individual patients with effective therapies will become ever more important."

Orion Genomics' MethylScope and MethylScreen technologies are used to discover and validate epigenetic biomarkers, which are changes to a layer of information written on top of the DNA molecule in the form of DNA methylation. DNA methylation controls whether or not a gene is turned on or off, also called gene-silencing. Epigenetic changes can be associated with disease risk, disease progression, and response to therapy.

About Orion Genomics

Orion Genomics, the Second Code Company, develops epigenetic research tools and molecular diagnostic products to fulfill the promise of personalized medicine. Orion's lead product is a simple blood-based test being developed to identify people at elevated risk for colorectal cancer. The company has active biomarker discovery programs in cancers of the bladder, breast, lung, ovaries and colon, and the company offers genomics services to the medical and agricultural and bio-fuels research communities. Orion Genomics is located in the Center for Emerging Technologies in St. Louis. For more information, visit the Orion Genomics website at

SOURCE Orion Genomics

SOURCE Orion Genomics
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Orion Genomics Gains Exclusive Worldwide Rights to the IGF2 Gene for Colorectal Cancer Risk Testing Through Licensing Agreement With Johns Hopkins University
2. Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
3. Genome Quebec and Montreal Heart Institute Pharmacogenomics Centre Deploys Isilon IQ in Next Generation of Drug Development
4. Curemark CEO Presents at Epigenomics Conference
5. Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership
6. Sirius Genomics Announces New Collaboration with Assistance Publique-Hopitaux de Paris
7. First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology
8. Clinical Genomics Continues Progress in Developing Biomarker Portfolio for Colorectal Cancer Testing
9. Prometheus and Rosetta Genomics Announce License and Collaboration Agreement
10. Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer
11. Rosetta Genomics Announces Commercial Availability of its First MicroRNA-Based Diagnostic Test; Will Host Teleconference to Discuss Launch of Future Tests
Post Your Comments:
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... , June 23, 2016 Bracket , ... launch its next generation clinical outcomes platform, Bracket eCOA (SM) ... held on June 26 – 30, 2016 in ... first electronic Clinical Outcome Assessment product of its kind to ... #715. Bracket eCOA 6.0 is a flexible platform ...
(Date:6/23/2016)... and BOGOTA, Colombia , June 23, 2016  Astellas today announced the establishment of Astellas ... Brasil as the company,s second affiliate in Latin America . ... ... of Astellas Farma Colombia ... ...
Breaking Medicine Technology:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned by ... to enhance the health of felines. The formula is all-natural and is made from ... the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, ... and his M.D from the David Geffen School of Medicine at UCLA. He trained ... Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where ...
Breaking Medicine News(10 mins):