Navigation Links
Orion Genomics Announces the Discovery of Novel Breast Cancer Biomarkers
Date:12/20/2007

- Study Identifies Novel Biomarkers Displaying 90% Sensitivity in Breast

Cancer -

ST. LOUIS, Dec. 20 /PRNewswire/ -- Orion Genomics announced today the discovery and validation of the most frequent DNA alterations detected in breast cancer to date. The results of a genome-wide analysis of DNA methylation appeared in PLoS ONE. The study entitled, "Identification of Novel High-Frequency DNA Methylation Changes in Breast Cancer" found more than 50 novel biomarkers, which were subsequently validated in up to 230 independent patient samples.

"Our study identified novel biomarkers that were individually capable of distinguishing early stage ductal breast cancer from normal and benign breast tissue," commented Jared Ordway, Ph.D., Director of Research and Development at Orion Genomics. "We are very excited about the potential of these findings as these biomarkers may be critical in the development of molecular diagnostics for the early detection of breast cancer."

Researchers applied a patented microarray-based approach to map tumor associated changes in DNA methylation, alterations that can affect normal gene expression. A single locus associated with the GHSR gene was the most powerful biomarker in the study, with a clinical sensitivity of 90% and a specificity of 96% for infiltrating ductal breast carcinoma. In addition to identifying biomarkers that might aid in the detection of breast cancer, the research revealed insights into the molecular mechanism of tumor development, which may lead to advances in breast cancer treatment.

"Twelve of our more than fifty breast cancer biomarkers exceeded the highest sensitivity previously reported for the stratification of tumor and normal tissue," added Nathan D. Lakey, President and CEO of Orion Genomics. "These results validate our biomarker discovery platform and our product pipeline, which is focused on breast, lung and ovarian cancer diagnostics."

About Orion Genomics

Orion Genomics, the Second Code biotechnology company, develops genomic research tools and molecular diagnostic products to detect cancer at its earliest stages and to aid in appropriate therapy selection. The company has active biomarker discovery programs in cancers of the bladder, breast, lung, ovaries and colon. Orion Genomics is located in the Center for Emerging Technologies in St. Louis. For more information, visit http://www.oriongenomics.com.


'/>"/>
SOURCE Orion Genomics
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
2. Harvard Medical School-Partners HealthCare Center for Genetics and Genomics Successfully Completes Evaluation of AutoGenomics 2C9-VKORC1 Panel to Assess Warfarin Sensitivity
3. Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors
4. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
7. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
8. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
9. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
10. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
11. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... TAIPEI, Taiwan , March 28, 2017 /PRNewswire/ ... medical device company, is pleased to announce ... Series A investment of Panther Orthopedics, Inc., a ... pioneering innovative dynamic fixation solutions for orthopedic extremity ... market continues to expand rapidly, primarily due to ...
(Date:3/28/2017)...  "US Cancer Generics Market Outlook 2022" report ... trend analysis related to the emergence and integration ... in US. The report analyzes various clinical and ... generics drugs in recent years. The introduction of ... dollars for various stake holders involved US cancer ...
(Date:3/28/2017)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) today ... and year ended December 31, 2016. ... Orexigen, beginning with the re-acquisition of the rights to ... team at Orexigen demonstrated remarkable focus, executing on a ... our Company while rewarding us full control of our ...
Breaking Medicine Technology:
(Date:3/29/2017)... Yorba Linda, Ca (PRWEB) , ... March 29, ... ... a standard process in many scientific laboratories. The assembly protocols involve many repetitive ... is well suited for automation, which enables the high-throughput needed, and results in ...
(Date:3/29/2017)... ... March 29, 2017 , ... The Wharton School of the University of Pennsylvania ... have made a $10 million gift to establish the Ken Moelis and Julie ... pathway to a Wharton MBA for highly-qualified Penn undergraduates whose academic and career interests ...
(Date:3/28/2017)... ... March 28, 2017 , ... For many women, getting birth control isn’t as easy as ... they either don’t have access to a health care facility or a pharmacy within 60 ... of the United States or for many who are faced with health or personal issues ...
(Date:3/28/2017)... ... ... The Thyroid Secret is a specialized 9-part documentary series ... recently launched on March 1, and Dr. Wentz discussed varied benefits and aspects ... Wentz is a licensed pharmacist and a foremost thyroid specialist. After being diagnosed ...
(Date:3/28/2017)... ... March 28, 2017 , ... Via Oncology, the leading provider ... a free, public-facing tool for analyzing the costs of various drug regimens in ... information to patients, providers, insurers and pharmaceutical companies about the estimated costs of ...
Breaking Medicine News(10 mins):