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Orexigen Therapeutics Announces the Light Study is Enrolling Faster than Originally Projected
Date:7/11/2012

g that the actual background MACE rate meets the expected 1.5% per year, the 87th MACE would occur in the second half of 2013.

"We are excited that the innovative tactics we are employing to enroll the Light Study are already paying dividends in the speed of recruitment of patients with the targeted MACE risk profile," said Dr. Preston Klassen, Senior Vice President and Head of Development. "While a number of factors contribute to the overall timing of event-driven trials, it is very encouraging that we have attracted so many patients into the study this quickly. If this rate continues, we should dramatically exceed our original enrollment goals."

About Orexigen Therapeutics Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. The Company's lead product candidate is Contrave, which has completed Phase III clinical trials and for which a New Drug Application has been submitted and reviewed by the FDA. The Company has also reached agreement with the FDA on a Special Protocol Assessment (SPA) for the Light Study, the Contrave cardiovascular outcomes trial. The Company's other product candidate, Empatic™, has completed Phase II clinical trials. Further information about the Company can be found at www.orexigen.com.

Forward-Looking Statements Orexigen cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "indicates," "will," "intends," "potential," "suggests," "assuming," "designed" and similar expressions are intended to identify forward-looking statements. These statements are based on the Company's current beliefs and expectations. These forward-looking statements include statements regarding the timing of enrollment and MACE events in the Light Study; the ability to enroll the targeted patient population; the ability
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