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Orexigen® Therapeutics Presents Multiple Contrave® Data Presentations at the 29th Annual Scientific Meeting of The Obesity Society
Date:10/3/2011

d reinforces the robustness of the results."

An oral presentation by Gene-Jack Wang, MD, Chair of Brookhaven Laboratory's Medical Department, will outline neuroimaging data from a clinical study conducted in collaboration with Brookhaven National Laboratory.  Changes in brain response to food cues with Contrave or placebo treatment were assessed using functional MRI imaging and showed that Contrave enhanced the activation of brain regions involved in inhibitory control, internal awareness, memory and cognition following exposure to food cues.  These results further support the postulated mechanism by which Contrave may help patients control food cravings.

In addition, new analyses from the COR-I and COR-BMOD Phase 3 studies will be presented.  On average 34% and 17% of patients in COR-I receiving Contrave therapy for 1 year achieved weight loss milestones of >/=10 or >/=15%, respectively.  This level of weight loss translates to losing 60-73% of excess body weight, which is in the range reported for surgical procedures such as gastric banding.

About Contrave

Contrave, an investigational combination therapy of naltrexone HCl SR and bupropion HCl SR, was studied for its ability to help people with obesity initiate and sustain weight loss of at least 5 percent of their starting body weight in one year.  Contrave was submitted for U.S. regulatory approval in March 2010.  The original submission was based on multiple clinical trials that evaluated Contrave in more than 4500 patients.  Orexigen received a Complete Response letter from FDA on January 31, 2011.

About Orexigen Therapeutics

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. Contrave has completed Phase 3 clinical trials, and the Company's other product candidate, Empatic(TM), has completed Phase 2 clinical trials. Further information about the Company can be f
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2. Orexigen® Therapeutics Schedules August 5, 2010 Webcast Discussion of Financial Results for the Second Quarter Ended June 30, 2010
3. Orexigen® Therapeutics Announces Publication of COR-I Phase 3 Study of Contrave in Lancet
4. Orexigen® Therapeutics COR-BMOD Study Published in the Journal Obesity
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