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Orexigen(R) Therapeutics Releases New Efficacy Data for Contrave(R) in Late Breaker Presentations at the 27th Annual Scientific Meeting of The Obesity Society
Date:10/27/2009

Contrave32 PBO Contrave32 (N=511) (N=471) (N=456) (N=702) -------------------------------------------------------------------------- Greater than or equal to 10% weight loss (%) 7.4% 24.6%* 5.7% 32.9%* -------------------------------------------------------------------------- Greater than or equal to 15% weight loss (%) 2.0% 11.9%* 2.4% 15.7%* -------------------------------------------------------------------------- Markers of Cardiometabolic Risk(+) -------------------------------------------------------------------------- COR-I COR-II -------------------------------------------------------------------------- PBO Contrave32 PBO Contrave32 (N=511) (N=471) (N=456) (N=702) -------------------------------------------------------------------------- Waist circumference (cm) 2.5 6.2* 2.1 6.7* -------------------------------------------------------------------------- Fasting triglycerides (mg/dL) 3.5 18.1* 0.5 11.8* -------------------------------------------------------------------------- Fasting HDL (mg/dL) 0.1 +3.4* 0.1 +3.6* -------------------------------------------------------------------------- Fasting LDL (mg/dL) -3.3 -4.4 2.1 6.2* -------------------------------------------------------------------------- hsCRP (mg/L) -0.4 -1.1* +0.2 -0.8* -------------------------------------------------------------------------- + Data based on intent-to-treat (ITT) last observation carried forward (LOCF) analyses of all randomized patients who had at
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SOURCE Orexigen Therapeutics, Inc.
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4. Orexigen(R) Therapeutics Schedules July 20, 2009 Teleconference and Webcast Discussion of Contrave(R) Phase 3 Results
5. Orexigen(R) Therapeutics Schedules September 30, 2009 Teleconference and Webcast to Discuss Phase 2b Trial Results From Second Obesity Drug Candidate, Empatic(TM)
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