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Orexigen(R) Therapeutics Appoints Peter Honig, M.D. to Board of Directors
Date:3/2/2010

0;"Peter brings direct, relevant experience in late stage development and global regulatory policy in primary care markets, expertise that will be valuable as Orexigen transitions to a commercial enterprise."

"The need for new effective therapies to manage the growing obesity epidemic is unquestionable.  Orexigen has taken a thoughtful and proactive approach in developing Contrave with regulatory and commercial success clearly in mind," added Dr. Honig.  "I look forward to being a member of the Orexigen board as the Company prepares to commercialize Contrave, develop Empatic™, and explore valuable lifecycle opportunities."

Prior to joining Merck, Dr. Honig was a Director in the Office of Drug Safety in the FDA's Center for Drug Evaluation and Research (CDER).  He originally joined CDER as a medical officer in the Division of Oncology and Pulmonary Drug Products.  Dr. Honig has served in various leadership roles in the American Society of Clinical Pharmacology and Therapeutics (ASCPT) including President, Vice President and member of the Board of Directors.  He is the current PhRMA representative to the International Conference on Harmonization (ICH) Steering Committee.

Dr. Honig received his Bachelors, Medical and Public Health degrees from Columbia University in

SOURCE Orexigen Therapeutics, Inc.
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3. Orexigen(R) Therapeutics Announces Changes to Its Clinical Programs and Management Team
4. Orexigen(R) Therapeutics Schedules July 20, 2009 Teleconference and Webcast Discussion of Contrave(R) Phase 3 Results
5. Orexigen(R) Therapeutics Schedules September 30, 2009 Teleconference and Webcast to Discuss Phase 2b Trial Results From Second Obesity Drug Candidate, Empatic(TM)
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