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Orexigen(R) Therapeutics Announces Changes to Its Clinical Programs and Management Team
Date:12/5/2008

parting group, for their extensive contributions to Orexigen. We believe we are in a very favorable position largely as a result of their efforts."

The Company is directing all of its efforts and resources to Contrave(R) and Empatic(TM), its obesity product candidates. It anticipates announcing the results from the first Phase 3 clinical trial for Contrave in January.

About Orexigen Therapeutics

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. The Company's lead combination product candidates are Contrave, which is in Phase 3 clinical trials, and Empatic, which is in the later stages of Phase 2 clinical development. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Further information about the company can be found at http://www.orexigen.com.

Forward-Looking Statements

Orexigen cautions you that statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "indicates," "will," "intends," "potential," "suggests," "assuming," "designed" and similar expressions are intended to identify forward-looking statements. These statements are based on the Company's current beliefs and expectations. These forward-looking statements include statements regarding the objectives of the Company's organizational changes, the enrollment, timing, execution, completion and announcement of results of clinical trials of Contrave and the potential to obtain regulatory approval for, and effectively treat obesity with its product candidates. The inclusion of forward-looking statements should not be regarded as a representation by Orexigen that any of its plans
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SOURCE Orexigen Therapeutics, Inc.
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