Navigation Links
Orexigen(R) Initiates Second Phase IIb Empatic(TM) Trial on Schedule
Date:7/9/2008

lesterol and coronary artery disease, among others. Research has shown that obesity has a greater impact on the development of chronic conditions in the U.S. than poverty, nicotine or alcohol abuse. Obesity also places a significant financial burden on the economy with mortality and morbidity costs estimated to exceed $100 billion annually.

Empatic combines zonisamide and bupropion, two existing drugs that have been independently approved by the U.S. Food and Drug Administration (FDA) to treat other central nervous system disorders. Orexigen has developed a proprietary sustained release (SR) formulation of zonisamide that has demonstrated a better tolerability profile than the legacy, immediate release (IR) formulation. These two drugs were selected based on their complementary activity in reducing appetite, increasing the body's burning of calories and sustaining weight loss.

The Company's other late-stage obesity product candidate, Contrave(R), is a combination of bupropion SR and naltrexone in a proprietary SR formulation that also appears to result in improved tolerability compared to the legacy naltrexone IR formulation. Contrave currently is being studied in four Phase III clinical trials that are fully enrolled. The program continues on schedule with initial results anticipated in late 2008 or early 2009 and the filing of a New Drug Application (NDA) with the FDA projected for late 2009.

Phase IIb Empatic Trial Details

ZB-202 is a randomized, double-blind, placebo-controlled trial involving approximately 720 generally healthy, nondiabetic obese patients at 20 sites nationwide. The primary endpoint for this trial is percent change in body weight after 24 weeks of blinded therapy. Patients will be randomized to one of six treatment groups including two of the Empatic doses associated with weight loss in the previous Phase IIb trial. The efficacy of Empatic will be compared against zonisamide monotherapy, bupropion monotherapy and pla
'/>"/>

SOURCE Orexigen Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Echo Therapeutics Initiates Clinical Study of Its Symphony(TM) Transdermal Continuous Glucose Monitoring System in Patients with Type 1 and Type 2 Diabetes
2. Sinovac Initiates Phase II Volunteer Enrollment for Split Viron Pandemic Influenza (H5N1) Vaccine
3. Mpex Initiates a Phase 2 Clinical Trial of Aerosol MP-376 in the Treatment of Chronic Bacterial Infections in Cystic Fibrosis Patients
4. Genmab Initiates Study of Zalutumumab With Radiotherapy in Head and Neck Cancer
5. iCAD Initiates Clinical Study of Its Virtual Colonoscopy CAD in Partnership with ACR Image Metrix
6. Peptimmune Initiates Phase Ib Study of PI-2301 in Multiple Sclerosis Patients and Presentation at BIO 2008
7. Transdel Initiates Ketotransdel(TM) Phase 3 Clinical Program for Pain
8. Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimers Disease
9. TorreyPines Therapeutics Initiates Clinical Trial to Evaluate Analgesic Effect of Oral Prodrug of Tezampanel
10. Nuvelo Initiates Phase 1B Clinical Trial of Anticoagulant NU172
11. Anadys Pharmaceuticals Initiates Phase I Clinical Trial of ANA598
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... Sept. 19, 2014 Kiromic, LLC, a ... Kent Hance , the former chancellor of Texas Tech ... as chancellor in July 2014, after raising $1.2 billion for ... Kent Hance , the most successful chancellor in the ... not only as an investor, but also as our new ...
(Date:9/19/2014)... CHICAGO , Sept. 19, 2014  4WEB Medical ... of 3D-printed foot and ankle osteotomy implants on ... and Ankle Society annual meeting in Chicago ... for all of a surgeon,s osteotomy needs with 74 size ... wedge systems had smaller offerings of only 15 to 18 ...
(Date:9/19/2014)...  Diplomat, the nation,s largest independent specialty pharmacy, has ... the Board of Directors on September 15, 2014. Mr. ... as chair of the Audit Committee. ... compliance and operating experience in the health care field.  ... financial officer, chief operating officer and secretary of Patient ...
Breaking Medicine Technology:Former Texas Tech Chancellor Named New Vice Chairman of the Board of Kiromic, LLC 24WEB Medical Unveils 3D-Printed Osteotomy Truss System 2David Dreyer Appointed to Diplomat Board of Directors 2
... Cempra Pharmaceuticals announced that Carl Foster has ...  Mr. Foster will be focusing on business development ... programs, the next-generation fluoroketolide solithromycin (CEM-101), that is ... pneumonia (CABP), and TAKSTATM (CEM-102 or fusidic acid), ...
... -- Dongsheng Pharmaceutical International Co., Ltd. (the "Company") (OTC ... it has obtained the exclusive sales rights of Thymosin ... Shanghai Biochemistry Pharmaceutical Co. I. The State ... the manufacturing permit of Thymosin Alpha 1 Injection for ...
Cached Medicine Technology:Cempra Pharmaceuticals Names Carl Foster Executive Vice President of Business Development 2Dongsheng Pharmaceutical International Co. Granted Exclusive Sales Rights for Thymosin Alpha 1 Injection 2Dongsheng Pharmaceutical International Co. Granted Exclusive Sales Rights for Thymosin Alpha 1 Injection 3
(Date:9/21/2014)... prevalence of preterm birth the birth of an ... a significant health problem that has increased over the ... Disease Control and Prevention (CDC), preterm birth affects nearly ... born in the U.S. While medical care has improved ... to positively impact the neurodevelopmental outcomes of preterm infants. ...
(Date:9/21/2014)... 2014 AstraZeneca’s Pulmicort is an ... and is used prophylactically for the maintenance treatment ... ingredient, budesonide, is an anti-inflammatory corticosteroid with a ... franchise includes the Pulmicort Flexhaler (budesonide) for adults ... age, Pulmicort Respules for children between one and ...
(Date:9/21/2014)... (PRWEB) September 22, 2014 PhUSE is ... and Dr. Lilliam Rosario as keynote speakers for their ... keynotes from Dr. Ben Goldacre in 2013 , ... Lord Winston in 2011 , PhUSE again presents high-calibre ... are passionate about advancement of clinical information. , Dr. ...
(Date:9/21/2014)... The Laboratory Testing Services industry is composed ... on items ranging from consumer and food products to ... operators to ensure the safety and quality of their ... government safety regulations and consumer lawsuits have led to ... revenue briefly dipped in 2009 as the US economy ...
(Date:9/21/2014)... September 22, 2014 The asthma ... decade, as it has become saturated with relatively ... inhaled corticosteroids (ICSs), inhaled corticosteroids and long-acting beta-agonists ... facing increasing generic competition. However, the launch of ... and ICS/LABA therapies delivered by the next-generation inhalers ...
Breaking Medicine News(10 mins):Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 2Health News:Research evaluates neurodevelomental and medical outcomes in single family room NICU 3Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Pulmicort Asthma Market (Epidemiology, Etiology, Symptoms, Diagnosis, Pathology) Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 2Health News:PhUSE announces Final List of Industry Influencers as Keynote Speakers 3Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Laboratory Testing Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 2Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 3Health News:Spiriva Asthma Market (Tiotropium Bromide) Analysis and Forecasts to 2023 in New Report Available at LifeScienceIndustryResearch.com 4
... moderate exercise has positive benefits on the hearts, holding ... in the last 10 to 20 years have shown ... suffering from congestive heart failure. ,However, the positive ... be statistically significant. ,In the new study rats ...
... of 62-year-old Moira Pullar on 17 January 2004 at Monklands ... who failed to cross check// the records in the hospital, ... bronchial pneumonia after cardiac arrest and brain damage. ... leading to the fatal dose. The warning signs of the ...
... The increasing number of people resorting to sleeping pills for ... more effective medications. However, they may not have the best ... ,The importance of sleep can be inferred form ... man healthy, wealthy and wise’. For those of them who ...
... in a panic after news that HIV infected blood had ... infected with the virus. A 35 year old female donor ... Conflicting statements are coming in from the authorities with regard ... blood. ,Russia faces the most serious HIV/AIDS problem ...
... that fruitfly gut stem cells and human intestine stem cells ... of both are alike. The similarity found between stem ... mechanims of cell regulation in digestive disorders and stomach cancers ... gastrointestinal tract as vertebrates. They have a mouth, an esophagus, ...
... faces further problems as it has emerged that more and ... and do not need the support of dentures, according// to ... ,The study says that as older people retain their own ... fillings and periodontal procedures like cleaning and curettage. Additionally, they ...
Cached Medicine News:Health News:Newer Generation Sleeping Pills Lack Superior Performance 2
ENDOlap™ laparoscopes provide excellent image linearity and flatness of field....
Superior imaging through a 410,000 pixel CCD, unseen color replication from a digital signal processor in the scope, and the added benefit of four way tip deflection make the TF410 a superior choice ...
The edge-to-edge clarity of the laparoscopes provides excellent image definition.Even small structures are easily recognized due to the optimal depth of focus. The outstanding optical quality provide...
The flexible nature of the vinyl allows the user to reach deeper into the chamber and allows for a greater comfort when working inside the glove box over a long period of time compared to any rigid s...
Medicine Products: