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OrbusNeich's Genous™ Stent is Safe and Effective in Cases Where Prolonged Dual Antiplatelet Therapy is Not Advisable as Presented at EuroPCR 2011
Date:5/19/2011

sufficiency and low and high body mass index (BMI).

"For patients who are known to be at an increased risk for bleeding or requiring urgent surgery, Genous is an ideal treatment strategy," said Dr. Hill.

In a presentation entitled "Endothelial progenitor cell-capture technology: mechanism of action and potential benefits," Eric Duckers, M.D., Ph.D., of Erasmus University Medical Center in The Netherlands presented clinical data from an ex vivo arteriovenous (AV) shunt model of human circulating blood which demonstrated that the Genous Stent increased the rate of endothelialization and reduced thrombogenicity compared to a bare metal stent (BMS).

"These data demonstrate the importance of CD34+ cells for endothelialization and the prevention of thrombosis," said Dr. Duckers. "This mechanism of early endothelialization supports the design of the unique EPC capture technology of Genous."

Stephen Wai-Luen Lee, M.D., Chief in Cardiology, Queen Mary Hospital at the University of Hong Kong, presented data from a pilot study on very early healing of the Genous EPC capturing stent using frequency domain optical coherence tomography (FD-OCT) technology – the EGO Study in 50 patients (still enrolling).  By 15 days, a very significant portion of the stent struts were covered by neointima, and close to 100% strut coverage was observed with the Genous Stent at 28 days.

"The degree of stent coverage over a time frame of two to six weeks has been documented graphically, revealing a progressive healing with stent coverage over time and possibly signifying the healing benefits of the EPC capturing technology," said Prof. Lee. "Such early findings have never been documented or reported in other types of stents, BMS and DES included."

Michael Haude, M.D., of Medical Clinic I at the Lukaskrankenhaus in Neuss, Germany, and Sigmund Silber, M.D., Ph.D., of Kardiologische Klinik Dr Muller, Munich, chaired the event.

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2. 100 Percent Coverage of Struts and Complete Neointimal Coverage of OrbusNeichs Genous™ Bio-engineered R stent™ Demonstrated 26 Days Post-Implantation in STEMI Patient
3. OrbusNeichs Genous™ Bio-engineered R stent™ Shows Favorable Safety Profile and Clinical Outcomes in Combination with Paclitaxel-Coated Balloon for De Novo Coronary Artery Disease
4. Data from Multiple Clinical Trials of OrbusNeichs Genous™ Bio-engineered R Stent™ Demonstrate Safety and Effectiveness Across Challenging Patient Subsets as Presented at TCT 2010
5. Randomized Clinical Trial of OrbusNeichs Genous™ Bio-engineered R stent™ in China Completes Patient Enrollment
6. OrbusNeichs Genous™ Stent Shows Favorable Outcomes for Treatment of Coronary Artery Bifurcation Lesions Compared to Bare Metal Stents
7. OrbusNeich Granted Expanded U.S. Patent of Genous™ Endothelial Progenitor Cell Capture Technology
8. Safety and Efficacy of OrbusNeichs Genous™ Stent Demonstrated in High-Risk Patients with Known Contraindications for Dual Antiplatelet Therapy
9. Published Data From e-HEALING Registry Demonstrate Good Clinical Outcomes With Low Incidence of Repeat Revascularization and Stent Thrombosis for OrbusNeichs Genous™ Stent
10. Data Published in the Journal of Interventional Cardiology Demonstrate Effectiveness and Safety of OrbusNeichs Genous™ Stent in Diabetic Patients
11. Cypher(R) Sirolimus-Eluting Coronary Stent Demonstrates Sustained Clinical Benefits Compared to Bare Metal Stents in Five-Year Randomized Clinical Trial With No Differences in Long-Term Safety
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