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OrbusNeich's Genous™ Stent is Safe and Effective in Cases Where Prolonged Dual Antiplatelet Therapy is Not Advisable as Presented at EuroPCR 2011
Date:5/19/2011

sufficiency and low and high body mass index (BMI).

"For patients who are known to be at an increased risk for bleeding or requiring urgent surgery, Genous is an ideal treatment strategy," said Dr. Hill.

In a presentation entitled "Endothelial progenitor cell-capture technology: mechanism of action and potential benefits," Eric Duckers, M.D., Ph.D., of Erasmus University Medical Center in The Netherlands presented clinical data from an ex vivo arteriovenous (AV) shunt model of human circulating blood which demonstrated that the Genous Stent increased the rate of endothelialization and reduced thrombogenicity compared to a bare metal stent (BMS).

"These data demonstrate the importance of CD34+ cells for endothelialization and the prevention of thrombosis," said Dr. Duckers. "This mechanism of early endothelialization supports the design of the unique EPC capture technology of Genous."

Stephen Wai-Luen Lee, M.D., Chief in Cardiology, Queen Mary Hospital at the University of Hong Kong, presented data from a pilot study on very early healing of the Genous EPC capturing stent using frequency domain optical coherence tomography (FD-OCT) technology – the EGO Study in 50 patients (still enrolling).  By 15 days, a very significant portion of the stent struts were covered by neointima, and close to 100% strut coverage was observed with the Genous Stent at 28 days.

"The degree of stent coverage over a time frame of two to six weeks has been documented graphically, revealing a progressive healing with stent coverage over time and possibly signifying the healing benefits of the EPC capturing technology," said Prof. Lee. "Such early findings have never been documented or reported in other types of stents, BMS and DES included."

Michael Haude, M.D., of Medical Clinic I at the Lukaskrankenhaus in Neuss, Germany, and Sigmund Silber, M.D., Ph.D., of Kardiologische Klinik Dr Muller, Munich, chaired the event.

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