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OrbusNeich's Genous™ Stent Demonstrates Most Rapid Coronary Vessel Healing Compared to Bare Metal and Drug Eluting Stents at 14 Days Post-Implantation
Date:11/9/2011

SAN FRANCISCO, Nov. 9, 2011 /PRNewswire/ -- OrbusNeich today announced that the company's Genous Stent provides the most rapid healing of the coronary vessel compared with bare metal stents and drug eluting stents (DES) at 14 days post-implantation. The data were presented by Ladislav Groch, M.D., of the University Hospital St. Anna, Brno, Czech Republic, in the Featured Clinical Research II session at Transcatheter Cardiovascular Therapeutics (TCT) 2011 in San Francisco.

The prospective, single-center, randomized study compared the endothelial stent coverage of the Blazer™ Cobalt Chromium Stent, the cobalt chromium SolarFlex stent and the biolimus eluting coronary stainless steel Nobori® stent with the Genous Stent, measuring optical coherence tomography (OCT) at 14 days. The percentage of healed struts – a proxy for endothelial coverage, the most powerful predictor of stent thrombosis – was significantly higher in the Genous Stent compared to the analyzed cobalt chromium stents and the DES. Specifically, the Genous Stent had 69.7 percent healed and 5.3 percent malapposed struts compared to 56.7 percent healed and 19.7 percent malapposed struts for the Blazer Stent, 55.2 percent healed and 13.9 percent malapposed struts for the SolarFlex stent and 34 percent healed and 45.7 percent malapposed struts for the Nobori stent.

"These data confirm that the endothelial progenitor cell-capturing Genous Stent accelerates the healing of the coronary vessel wall following percutaneous coronary intervention relative to bare metal stents and DES," said Dr. Groch. "Early healing is a powerful predictor of subacute and late stent thrombosis, and the high percentage of covered struts seen with the Genous Stent potentially minimises the length of dual antiplatelet therapy. This is especially important for patients with an increased risk for bleeding."

The primary endpoint of the study was the percentage of covered struts. Secondary endp
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SOURCE OrbusNeich
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2. Data Published in Circulation Journal Show OrbusNeichs Genous™ Stent Is Safe and Effective in Elderly Patients
3. Two-Year Follow-Up Data Show Outstanding Clinical Outcomes and Safety for OrbusNeichs Genous™ Stent in Patients at High Risk for Restenosis
4. OrbusNeichs Genous™ Stent Enables Early and Safe Discontinuation of Dual Antiplatelet Therapy in High-Risk Patients Requiring Nondeferrable, Non-Cardiac Surgery
5. Study Confirms that OrbusNeichs Genous™ Stent Effectively Captures Circulating Endothelial Progenitor Cells to Accelerate Re-Endothelialization and Decrease Thrombogenicity
6. OrbusNeichs Genous™ Stent is Safe and Effective in Cases Where Prolonged Dual Antiplatelet Therapy is Not Advisable as Presented at EuroPCR 2011
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8. Published Data From e-HEALING Registry Demonstrate Good Clinical Outcomes With Low Incidence of Repeat Revascularization and Stent Thrombosis for OrbusNeichs Genous™ Stent
9. Safety and Efficacy of OrbusNeichs Genous™ Stent Demonstrated in High-Risk Patients with Known Contraindications for Dual Antiplatelet Therapy
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