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OrPro Therapeutics Receives NIH Grant Award to Advance Development of Recombinant Thioredoxin for Treatment of Cystic Fibrosis
Date:7/31/2012

r, CO by pediatric pulmonologist Dr. Carl White, M.D.  In 2011, OrPro licensed from NJH an intellectual property portfolio claiming compositions and uses of the thioredoxin active site for the treatment of pulmonary disease.  Dr. White (now at University of Colorado Denver/Children's Hospital Colorado), and his NJH colleague Dr. David Nichols are medical advisors to the company, and will collaborate on the NIH-funded project. 

"We have assembled a world-class team of experts in research, preclinical/clinical development, biologics manufacturing, and finance to help guide OrPro in the development of this exciting new product candidate," said Heifetz, who is also principal investigator on the SBIR grant. "We believe the support from NIH will act as a catalyst for the company and we look forward to completing an initial round of financing to accelerate our development efforts."

About OrPro

OrPro Therapeutics, Inc. is a pre-clinical stage biopharmaceutical company headquartered in San Diego, CA. The company's goal is to develop a breakthrough class of safe, well-tolerated and more effective inhaled non-systemic drugs based on the thioredoxin active site for the treatment of patients with cystic fibrosis (CF), COPD/emphysema, bronchiectasis, severe asthma, and other serious obstructive pulmonary diseases. These diseases are characterized by thickened mucus resulting in impaired lung function. Poor clearance of abnormal, sticky mucus is associated with chronic infection and premature death, especially in CF. Despite advances in antibiotic therapy and other treatments there remains a large unmet medical need for improved mucus-reducing (mucolytic) drugs which in many cases are the most efficacious means of mitigating disease symptoms. Effective new treatments for CF are forecast to achieve peak annual sales in excess of $1 billion annually. OrPro's lead product, ORP-100, an aerosolized variant of recombinant human thioredoxin, wil
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SOURCE OrPro Therapeutics, Inc.
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