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OptiNose mottar stipend for nese-til-hjerne-forskning innen spektrumet for autismesykdommer
Date:11/8/2012

id som oppstår naturlig på et trygt vis for å stimulerer laktasjon hos ammende kvinner. Det har i den senere tid vekket oppmerksomhet som et potensielt nyskapende behandlingsalternativ for flere psykiatriske sykdommer, inklusiv autisme (Bartz 2008, Ishak 2010, Feifel 2010, Neumann 2008, Kosfeld 2005). Oksytocin har en veldig dårlig oral biotilgjengelighet og med standard nasal levering (flytende spray) når omtrent 3 prosent av medisinen den systemiske blodsirkulasjonen. Det vurderes imidlertid at kun en liten del (under 0,01 prosent) av oksytocin i blodet kommer til hjernen på tvers av blodhjernebarrieren, og oppnår en direkte «nese-til-hjerne»-levering er en spennende mulighet.

Virkningene av tradisjonelle intranasale leveringssprayer for oksytocin på flere psykiatriske sykdommer har blitt undersøkt i flere små kliniske studier (Hollender 2007, Gaustella 2009, Andari 2010). De fleste av disse studiene foreslår fordelaktige virkninger, for det meste på aggresiv og paranoid atferd.

  • I disse studiene har høye doser (40-80IU) vanligvis blitt brukt og representerer en logistisk utfordring pga. væskemengden som kreves for å levere disse dosene og utgjør en risiko for langvarige, negative virkninger forbundet med vann- og elektrolyttubalanse.
  • OptiNose Bi-Directional™ nasale leveringsapparater bruker et tørt pulver, som på et unikt vis er i stand til å nå de øvre posteriore nasale regionene. Disse regionene gir en større adgang til luktnerven, og projiserer direkte til hjerneregionene som styrer atferd og følelser og dermed potensialet for «nese-til-hjerne»-aktivitet.
  • OptiNose-apparatet tilbyr potensiale for en mer effektiv og konsistent direkte transport av oksytocin til selve hjernen, via denne nerven, ved bruk av relativt lave doser – som i en betydelig grad
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SOURCE OptiNose US Inc.
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