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Opportunity Exists in the U.S. for Novel Agents in Crohn's Disease and Ulcerative Colitis, Owing to Discontinued Use of Leading Anti-TNF Agents Driven by Efficacy Failures
Date:12/10/2013

is agent within a year of its launch. Fewer expect to prescribe vedolizumab for UC; the approval of Janssen's Simponi for UC in 2013 may have lessened the urgency for movement out of the anti-TNF drug class. While surveyed gastroenterologists cite preference for a different mechanism of action and potential for improved long-term remission over Remicade as the main factors for prescribing vedolizumab (at the same copay) before prescribing anti-TNFs, MCO data suggest the likelihood that the novel agent will have same copay as Remicade is low.   

"While 93 percent of surveyed payers indicate that their plan would reimburse vedolizumab if priced the same as Remicade, patients are unlikely to encounter the same copay with the highest percentage of payers anticipating its placement on specialty tier, thus likely delaying use to after failure with at least one anti-TNF," said Decision Resources Analyst Kathrina Quinn, Ph.D.

The novel agent Xeljanz will also face difficulty in achieving favorable formulary inclusion for UC. According to most surveyed payers, the oral agent is currently covered as a non-preferred brand for rheumatoid arthritis, with over half of these plans not expecting its tiering to change within its first year of availability for UC.

About Decision Resources
Decision Resources (www.decisionresources.com) is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources Group company.

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resourc
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