Navigation Links
Opportunity Exists in the U.S. for Novel Agents in Crohn's Disease and Ulcerative Colitis, Owing to Discontinued Use of Leading Anti-TNF Agents Driven by Efficacy Failures

BURLINGTON, Mass., Dec. 10, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that lack of initial response or waning efficacy over time are the main reasons that patients discontinue treatment with leading anti-TNFs, Janssen's Remicade and AbbVie's Humira in Crohn's disease (CD) and ulcerative colitis (UC), according to surveyed gastroenterologists. Furthermore, gastroenterologists estimate that one-fifth of their patients taking these agents express dissatisfaction and are eager to switch to an alternative therapy that can achieve higher rates of clinical remission and maintain clinical remission. If the following emerging therapies with novel mechanisms of action—Takeda's CAM inhibitor vedolizumab for CD and UC, Janssen's IL-12/IL-23 inhibitor Stelara for CD and Pfizer's oral Jak inhibitor Xeljanz for UC—can meet physicians' expectations about efficacy, such agents should be well positioned. However, because cost-related issues such as a lower list price than anti-TNFs are cited by managed care organizations (MCOs) as key drivers for favorable formulary inclusion, such therapies will likely face challenges obtaining preferential coverage since many plans already cover Remicade and Humira on tier 2.


The U.S. Physician & Payer Forum report entitled Promising Pipelines for Crohn's Disease and Ulcerative Colitis: Payer and Prescriber Receptivity as the Market for Premium-Priced Therapies Expands Beyond the TNF-alpha Inhibitors finds that, among all emerging therapies, the greatest opportunity exists for vedolizumab's use in CD, with over two-thirds of gastroenterologists expecting to prescribe this agent within a year of its launch. Fewer expect to prescribe vedolizumab for UC; the approval of Janssen's Simponi for UC in 2013 may have lessened the urgency for movement out of the anti-TNF drug class. While surveyed gastroenterologists cite preference for a different mechanism of action and potential for improved long-term remission over Remicade as the main factors for prescribing vedolizumab (at the same copay) before prescribing anti-TNFs, MCO data suggest the likelihood that the novel agent will have same copay as Remicade is low.   

"While 93 percent of surveyed payers indicate that their plan would reimburse vedolizumab if priced the same as Remicade, patients are unlikely to encounter the same copay with the highest percentage of payers anticipating its placement on specialty tier, thus likely delaying use to after failure with at least one anti-TNF," said Decision Resources Analyst Kathrina Quinn, Ph.D.

The novel agent Xeljanz will also face difficulty in achieving favorable formulary inclusion for UC. According to most surveyed payers, the oral agent is currently covered as a non-preferred brand for rheumatoid arthritis, with over half of these plans not expecting its tiering to change within its first year of availability for UC.

About Decision Resources
Decision Resources ( is a world leader in market research publications, advisory services and consulting designed to help clients shape strategy, allocate resources and master their chosen markets. Decision Resources is a Decision Resources Group company.

About Decision Resources Group
Decision Resources Group is a cohesive portfolio of companies that offers best-in-class, high-value information and insights on important sectors of the healthcare industry. Clients rely on this analysis and data to make informed decisions. Please visit Decision Resources Group at

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

SOURCE Decision Resources
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Sphere Fluidics: Expanding Executive Team for Growth of New Market Opportunity
2. New Primer Co-Authored by Novation Describes Potential Impact of Biosimilars on Pharmacy Practice; Opportunity for Hospitals to Manage Drug Expenditures
3. Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity
4. Obesity Therapeutics to 2019 - Safety Concerns Hinder Drug Performance Despite Large Market Opportunity
5. Aratana Therapeutics Drives Awareness of Pet Therapeutic Opportunity During "CVC Week" in Kansas City
6. OpportunityAnalyzer: Acute Myeloid Leukemia (AML) - Opportunity Analysis and Forecasts to 2017
7. Imprimis Pharmaceuticals, Inc. Acquires Intellectual Property for Ophthalmic Compound Development Opportunity
8. Sorrento Therapeutics Receives Frost & Sullivans Prestigious 2013 Global Investment Opportunity Award in the Oncology Market
9. Sorrento Therapeutics Receives Frost & Sullivans 2013 Global Investment Opportunity Award in Oncology
10. Post-ACA Implementation Brings Opportunity And Uncertainty To Pharmaceutical Companies Looking To Capture Growth In New Places
11. Surveys Reveal Opportunity for Medical Community to Fully Embrace Biomarker Testing in Lung Cancer
Post Your Comments:
(Date:12/1/2015)... Research and Markets ( ) ... Global Enteric Disease Testing Market: Campylobacter, Cryptosporidium, E. ... Germany, Italy, Japan, Spain, UK, US" report ... . --> Japan ... based on a combination of primary and secondary ...
(Date:12/1/2015)... , December 1, 2015 /PRNewswire/ ... announced the addition of the  "2016 ... Forecasts, Innovative Technologies, Competitive Strategies, Emerging ... UK), Japan"  report to their offering. ... announced the addition of the  "2016 ...
(Date:12/1/2015)... och UPPSALA, Sverige, December 1, 2015 ... International Breast Cancer Study Group (IBCSG, ... Bryssel) att ingå i en klinisk studie av ... --> --> Studien, med namn ... behandlas med anti-hormonella läkemedel i kombination med palbociclib, ...
Breaking Medicine Technology:
(Date:12/1/2015)... ... ... Lutronic, a leading innovator of aesthetic and medical laser and energy-based technology, ... in the United States. Clarity is a Superior Dual Wavelength Platform which combines ... single platform that is easy to own and operate. , For over a ...
(Date:12/1/2015)... ... 01, 2015 , ... TCS Healthcare Technologies (TCS), a leading ... arenas, is pleased to announce that VIP Care Services, a Caprock Health Group ... ACUITY Complete Care™ Management to back their collaborative catastrophic case management initiatives. ACUITY ...
(Date:12/1/2015)... ... December 01, 2015 , ... PYA’s latest white paper, ... addresses a main “pain point” for merging or aligning healthcare provider organizations—when mergers ... is signed. This quick-read guidance suggests that failing to recognize the power ...
(Date:12/1/2015)... ... December 01, 2015 , ... XTC Semifinals 2016 - CES, Las Vegas, ... Las Vegas for CES 2016, the world’s largest Consumer Electronic Show, where they will ... Shapiro, Founding Partner of Pacific Investments Veronica Serra, and venture capitalist Tim Draper among ...
(Date:12/1/2015)... ... December 01, 2015 , ... PartnerTech , a ... and leadership since 2008. Gary Bruce, President of PartnerTech North America, currently serves ... a significant amount of time in Sweden since joining PartnerTech based in Malmo, ...
Breaking Medicine News(10 mins):