Navigation Links
Onyx Pharmaceuticals to Acquire Proteolix, Inc.
Date:10/12/2009

EMERYVILLE, Calif., Oct. 12 /PRNewswire-FirstCall/ -- Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX) today announced that it has signed a definitive agreement to acquire Proteolix, Inc., a privately held biopharmaceutical company focused on discovering and developing novel therapies that target the proteasome for the treatment of hematological malignancies and solid tumors. Proteolix's lead compound, carfilzomib, is a proteasome inhibitor currently in multiple clinical trials, including an advanced Phase 2b clinical trial for patients with relapsed and refractory multiple myeloma.

"Carfilzomib is a next generation product candidate with a proven and well-validated mechanism of action, strong efficacy signals, demonstrated tolerability and a potential accelerated approval pathway," said N. Anthony Coles, M.D., president and chief executive officer of Onyx. "This acquisition leverages Onyx's proven expertise in developing and commercializing Nexavar® and provides strategic expansion into the $16 billion hematological malignancies market. The transaction structure reflects our approach to growing our business in a disciplined fashion, including earnout payments contingent on specific approval-based events. In addition, our development plan is designed to maintain our ability to continue to grow operating cash flow in 2010 and beyond."

Under the terms of the transaction, Onyx will make a $276 million cash payment upon closing of the transaction. Additional payments include $40 million payable in 2010 based on the achievement of a development milestone and up to $535 million contingent upon the achievement of certain regulatory approvals for carfilzomib in the U.S. and Europe. Of the potential $535 million, a payment of $170 million is based upon the achievement of accelerated U.S. Food and Drug Administration approval. The t
'/>"/>

SOURCE Onyx Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
2. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
3. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
4. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
5. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
6. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
7. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
8. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
9. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
10. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
11. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... Statistics released from a number of organizations ... during the holidays, beginning with Thanksgiving eve, which is ... The data, highlighted in an Infographic ... of their annual Sober Days for the Holidays ... drinking and increased rates of DUI injuries and deaths ...
(Date:11/22/2014)... 2014 Many power shifts are occurring ... of patients in the biopharmaceutical market is impacting ... than ever, understanding how to effectively acquire, convert, ... essential. According to recent research ... spent about two-thirds of their patient-focused dollars on ...
(Date:11/21/2014)... DIEGO , Nov. 21, 2014  Tandem ... TNDM ), a medical device company and manufacturer ... announced a partnership with Tidepool, a non-profit dedicated ... open source software platform that increases diabetes data ... Tidepool Platform, which is currently under development, to ...
Breaking Medicine Technology:Alarming Stats Show Holiday Drinking an Issue for Many 2New Report Details Importance of Adopting a "Patient Journey" Framework in Marketing 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
... Cantel Medical Corp. (NYSE: CMN ) will release the ... Tuesday, June 8 before the market opens, and hold a conference call ... call will be Charles M. Diker , Chairman; Andrew A. Krakauer ... Craig A. Sheldon , Senior Vice President, CFO and Treasurer; and Roy ...
... Fla. , June 1 In a ... records management, MedeFile International, Inc. (OTC Bulletin Board: MDFI.OB), ... announced the signing of an unprecedented agreement with Dr. ... and Registered Nurse in the practice will be incorporating ...
Cached Medicine Technology:Cantel Medical Corp. to Hold Conference Call to Discuss Results for Its Third Quarter Ended April 30, 2010 2In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 2In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 3In First of Its Kind Setup, MedeFile Interfacing Directly with Physician's Office 4
(Date:11/24/2014)... 2014 The typical American diet includes ... ingredients. Consistently consuming a diet high in calories and ... excess fat that typically accumulate around the internal organs ... ugly head in the form of love handles, beer ... the decision to rid themselves of the burden of ...
(Date:11/24/2014)... CO, and Philadelphia, PA (PRWEB) November 24, 2014 ... provider of care coordination and disease management services ... has chosen to implement Essette’s Medical Management software ... new Essette SaaS platform in a program to ... Essette suite includes Population Health Management, Care Management, ...
(Date:11/24/2014)... San Diego, California (PRWEB) November 24, 2014 ... the San Diego Fertility Center, recently appeared on NBC to ... preservation option. Egg freezing has been trending in the news ... covering this expensive procedure for women. , “[The ... the women who are on a career hot path.” Says ...
(Date:11/23/2014)... The clinical trial report, "Aspergillosis ... on the Aspergillosis clinical trial scenario. This report ... clinical trials on Aspergillosis. It includes an overview ... as per the site of trial conduction across ... of disease clinical trials by their phase, trial ...
(Date:11/23/2014)... For the coming special Friday, Tidebuy, a ... great promotion for many products, especially the beautiful colored ... best choice with amazing discounts, up to 90% off. ... It is easy to buy colored wedding dresses in ... is also famous for delicate craftsmanship, elegant style and ...
Breaking Medicine News(10 mins):Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4Health News:ReAdmission Solutions, LLC Selects Essette 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 2Health News:Dr. Michael Kettel of San Diego Fertility Center Gives “An Inside Look at Freezing Eggs” on NBC 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 2Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 3Health News:Aspergillosis Pipeline and Clinical Trials Market (Compnies and Drugs) Review H2 2014 Report at ReportsnReports.com 4Health News:Beautiful Wedding Dresses Available at Popular B2C Company Tidebuy 2
... national patient safety initiative involving major corporate employers ... goals, but success relies greatly on regional health ... implementation, says a recent study., "While employers and ... safety, actual success depends greatly on individual hospitals ...
... who think they are too fat is worse than ... result of the all Germany Health Interview and Examination ... Koch Institute, as presented by Brbel-Maria Kurth and Ute ... International (Dtsch Arztebl Int 2008, 105[23]: 406-12). , ...
... if children with a urinary tract disorder known as ... for an extended period of time are seeking to ... Intervention for Children with Vesicoureteral Reflux (RIVUR) study is ... and Kidney Diseases (NIDDK), one of the National Institutes ...
... release is available in Spanish . , A ... concluded that there are opioid and cannabinoid receptors ... spermatozoid. The research by Mr Ekaitz Agirregoitia opens the door ... Freshly released spermatozoids cannot achieve fertilisation, they must undergo some ...
... Co-Founder and Attorney Christopher, Grell receives 40 page, 10 year study on ... 99% of distributors earn income, not counting ... expenses, of 13 dollars per week., OAKLAND, Calif., June 20 ... with a presence in over 30 countries,both Usana and Herbalife (NYSE: ...
... and physical exercise can improve coordination and movement ... development disorder that primarily affects females. , Using ... the Children,s Medical Research Institute in Sydney, researchers ... these mice responded positively to the effects of ...
Cached Medicine News:Health News:Changes in local health care markets affect national patient safety project 2Health News:Changes in local health care markets affect national patient safety project 3Health News:Changes in local health care markets affect national patient safety project 4Health News:'Feeling fat' is worse than being it 2Health News:Researchers seek children for a study of antibiotics for a urinary tract disorder 2Health News:Opioids and cannabinoids influence mobility of spermatozoids 2Health News:Opioids and cannabinoids influence mobility of spermatozoids 3Health News:New Lab Tests Reveal Herbalife, Usana Have 1,000 Times the Lead as Ensure, Boost 2Health News:New Lab Tests Reveal Herbalife, Usana Have 1,000 Times the Lead as Ensure, Boost 3Health News:Mental and physical exercise improves genetic mental impairment 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: