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Onyx Pharmaceuticals Provides Update on Carfilzomib at 53rd American Society of Hematology Annual Meeting
Date:12/10/2011

bortezomib-naive patients and patients previously treated with bortezomib. Prior therapies included alkylating agents, stem cell transplant, thalidomide, lenalidomide and anthracyclines, and bortezomib in the bortezomib-treated patients. The primary endpoint was ORR and secondary endpoints included CBR, TTP, DOR, OS and safety.
  • The 005 study was an open-label, single-agent Phase 2 study evaluating the safety and pharmacokinetics of carfilzomib in 50 patients with relapsed and refractory multiple myeloma with renal dysfunction. The primary endpoint was pharmacokinetics; the secondary endpoint was safety.
  • ASH Investor Teleconference
    Investigators and members of the Onyx management team will highlight data presented on carfilzomib featured at the 53rd ASH Annual Meeting and Exposition in San Diego, CA. The teleconference will begin at 10:00 a.m. PT on December 13, 2011.

    Interested parties may access the teleconference and the presentation that accompanies it on our website at:  
    http://www.onyx-pharm.com/investors/event-calendar

    or by dialing 847-585-4405 and using the passcode 31296220.  A replay of the presentation will be available on the Onyx website or by dialing 630-652-3042 and using the passcode 31296220# later in the day.  The replay will be available on the Onyx website until December 27, 2011.

    Carfilzomib Development Program
    Carfilzomib is being studied in several key clinical trials either as a single-agent or in combination with other therapies, including:

    • A Phase 3 clinical trial, known as the ASPIRE trial, is evaluating the combination of lenalidomide and low dose dexamethasone with or without carfilzomib in patients with relapsed multiple myeloma who have received one to three prior therapies. The company has an agreement with the FDA
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    SOURCE Onyx Pharmaceuticals, Inc.
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