Navigation Links
Onyx Pharmaceuticals Provides Update on Carfilzomib at 53rd American Society of Hematology Annual Meeting
Date:12/10/2011

d but variable adverse impact on therapeutic response and time to event. Of the 229 evaluable patients, 71 patients had unfavorable cytogenetic status. Cytogenetic abnormalities are defined as the presence of del 13 or hypodiploidy by metaphase cytogenetic analysis and/or del 17p13, t(4;14), t (14;16) by fluorescence in situ hybridization (FISH).  An analysis of the results showed that response rates to carfilzomib among patients with normal/favorable cytogenetics were comparable to rates among patients with unfavorable cytogenetic abnormalities.

About the Phase 2 studies

  • The 003-A0 study was an open-label, single-arm, Phase 2 study of carfilzomib in patients with relapsed and refractory multiple myeloma. The primary endpoint was ORR, and secondary endpoints included CBR, DOR, PFS, TTP and safety. Patients in the 003-A0 trial received carfilzomib at a dose of 20mg/m(2).
  • The 003-A1 study was an open-label, single-arm Phase 2b trial. The trial evaluated 266 heavily-pretreated patients with relapsed and refractory multiple myeloma who had received at least two prior therapies, including bortezomib and either thalidomide or lenalidomide. Refractory disease was defined as less than or equal to a 25 percent response or progression during therapy, or progression within 60 days after completion of therapy.[i]  Patients received carfilzomib at a dose of 20mg/m(2) for the first cycle, and were then dose-escalated to 27mg/m(2). The primary endpoint was ORR. Secondary endpoints included DOR, CBR, OS, TTP, PFS, and safety. 
  • The 004 study, an open-label, single-agent Phase 2 study of carfilzomib, was conducted in collaboration with the Multiple Myeloma Research Consortium (MMRC) and other institutions, and enrolled 129 patients with relapsed and/or refractory multiple myeloma who had received one to three prior treatments. Patients were divided into two populations:
    '/>"/>

SOURCE Onyx Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Radient Pharmaceuticals Submits an Abstract to the American Society of Colon and Rectal Surgeons
2. Arena Pharmaceuticals to Present at the Oppenheimer 22nd Annual Healthcare Conference
3. Webcast Alert: Isis Pharmaceuticals Holds Webcast to Discuss Recent Additions to its Development Pipeline
4. Survival Benefit With Syndax Pharmaceuticals Entinostat Maintained in Women with Advanced Breast Cancer
5. Ampio Pharmaceuticals Awarded European Patent that Strengthens Intellectual Property Protection for its key drug Ampion™
6. Inovio Pharmaceuticals Closes $4.0 Million Underwritten Financing
7. Onyx Pharmaceuticals to Host a Teleconference to Reprise Key Data From the American Society of Hematology Meeting
8. Avanir Pharmaceuticals Announces Date of Fiscal 2011 Fourth Quarter and Year End Financial Results and Conference Call
9. Anthera Pharmaceuticals Promotes Dr. Debra Odink to Chief Technology Officer
10. Ampio Pharmaceuticals Announces Agreement to Acquire Key Drug Delivery Technology
11. Radient Pharmaceuticals Two Abstracts Submitted to 2012 Gastrointestinal Cancers Symposium (ASCO) Regarding Onko-Sure® Utility in Colorectal Cancer Are Accepted for Presentation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... 2014  PTC Therapeutics, Inc. (NASDAQ: PTCT ... webcast conference call to report its second quarter 2014 ... business and outlook on Thursday, August 7, 2014 at ... The call can be accessed by ... minutes prior to the start of the call and ...
(Date:7/24/2014)... July 24, 2014  Abaxis, Inc. (NasdaqGS: ... analysis systems, today reported financial results for the first ... quarter overview: , Revenues of $47.5 million, up ... EPS of $0.21, up 50% over last year,s comparable ... revenues of $7.2 million, up 20% over last year,s ...
(Date:7/24/2014)... 2014 IGI Laboratories, Inc. (NYSE MKT: IG), ... generic pharmaceutical company, today announced it has accepted  ... Mr. Finio has accepted a senior level finance position ... his acceptance of his new position, Mr. Finio will ... for IGI Laboratories, Inc.  The effective date of his ...
Breaking Medicine Technology:Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 2Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 3Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 4Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 5Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 6Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 7Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 8Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 9Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 10Abaxis Reports Financial Performance for the First Quarter of Fiscal 2015 11IGI Laboratories, Inc. Announces Change To Its Board Of Directors 2
... Feb. 1, 2011 /PRNewswire-Asia-FirstCall/ --  China Medicine Corporation ... "Company"), a leading manufacturer, developer and distributor of ... health products in the People,s Republic of China, ... manufacturing license from the Chinese Ministry of Agriculture ...
... 2011 Stryker Corporation (NYSE: SYK ) ... of its OP-1 product family, which includes OP-1 Implant, ... bone applications. The transaction also includes the sale of ... Stryker is one of the world,s leading medical technology ...
Cached Medicine Technology:China Medicine Corporation Receives Manufacturing License for rADTZ 2China Medicine Corporation Receives Manufacturing License for rADTZ 3
(Date:7/24/2014)... shuts off nighttime production of the hormone melatonin, renders ... breast cancer drug, says a new study by Tulane ... and Melatonin Disruption by Exposure to Light at Night ... published in the journal Cancer Research , is ... the success of tamoxifen in treating breast cancer. , ...
(Date:7/24/2014)... Ticket Down is a reliable source ... at the Sports Authority Field on July 26th. For the ... has brought some of the best club teams from around the ... still being raved about weeks after its completion, fans – new ... of the biggest stars in the world compete. Some of these ...
(Date:7/24/2014)... 2014 Four Seasons Resort Maui ... its $3 million renovation of the famed Maile suite ... suites, just in time to welcome summer guests vacationing ... direction from the internationally-acclaimed BraytonHughes Design Studios, San Francisco ... property and the largest in Hawaii—received a complete re-envisioning. ...
(Date:7/24/2014)... In a July 9th article in the Money ... Lotus Blossom Consulting LLC , was quoted in a Family ... Cut the High Cost of Infertility . Her advice began ... maximize your chance of success from the first attempt.” The ... “I am always happy to talk with the media ...
(Date:7/24/2014)... (PRWEB) July 24, 2014 CarePoint ... specialist in hematology and oncology, Dr. Hitendra Upadhyaya, ... Our system welcomes Dr. Upadhyaya to the community. ... CarePoint Health Medical Group, a comprehensive network of ... a wide range of specialties. This latest acquisition ...
Breaking Medicine News(10 mins):Health News:Total darkness at night is key to success of breast cancer therapy -- Tulane study 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 2Health News:Manchester United vs. AS Roma Tickets Denver Sports Authority Field at Mile High: Ticket Down Cuts Ticket Prices for Guinness International Champions Cup Match 3Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 2Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 3Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 4Health News:Four Seasons Resort Maui's Newly Designed Top Suites Debut 5Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 2Health News:Mindy Berkson, Infertility Expert and Founder, Lotus Blossom Consulting LLC: Leading the Pathway to Parenthood 3Health News:Dr. Upadhyaya Joins CarePoint Health Medical Group 2
... on Science, Not IdeologyWASHINGTON, March 23 Today, the ... York ruled that the Food and Drug Administration (FDA) ... dedicated emergency contraceptive product) based on age was "arbitrary ... faith decision-making." The court ordered the FDA to extend ...
... Recommended levels in foods need to be increased, experts ... the course of two decades, vitamin D levels have ... Low levels of vitamin D have been associated with ... adults. Recent research has also linked insufficient vitamin D ...
... seen with tightest control of risk factors, researchers report ... control of the major risk factors for heart disease ... a new study shows. , And so the current ... LDL cholesterol might need to be tightened even further, ...
... a Decision Based on Scientific Fact, Not PoliticsNEW YORK, March ... the Eastern District of New York rejected the Food and ... emergency contraceptive Plan B to women over 18, ruling that ... The court ordered the agency to reconsider its decision. ...
... in Virginia, West Virginia and Maryland to hold annual convention recognizing ... ... 23, 2009 -- 200 emergency and 911 professionals will gather in ... safety sector. The 16th Annual Tri-State Telecommunicators Banquet and Awards ...
... Inform Healthcare DecisionsPHILADELPHIA, March 23 ... when selecting a hospital for treatment, thanks to ... and facility.Synthesizing extensive data from the 2003-2007 ... Hospital Performance Reports (PHC4) into a searchable format, ...
Cached Medicine News:Health News:Advocates for Youth Applauds Court Ruling on EC Age Restriction 2Health News:Many Americans Fall Short on Their Vitamin D 2Health News:Many Americans Fall Short on Their Vitamin D 3Health News:Many Americans Fall Short on Their Vitamin D 4Health News:Lowest Blood Pressure, Cholesterol Levels the Best 2Health News:Lowest Blood Pressure, Cholesterol Levels the Best 3Health News:Federal Court Rules FDA Must Reconsider Plan B Decision 2Health News:Federal Court Rules FDA Must Reconsider Plan B Decision 3Health News:LLE to Sponsor 16th Annual Tri-State Telecommunicators Banquet and Awards Ceremony 2Health News:New Site Compares Pennsylvania Hospitals 2
... mini-cells has always distinguished itself by ... tradition continues with the patented XCell ... gel tension wedge in place of ... models makes the XCell SureLock and ...
... Multidizer is designed with a variety of ... - all in one unit. Shake, rock, ... operating compartments allow for hybridization and blotting ... , The upper chamber uses a ...
... unit ideal for use in laboratories with low ... set at 12 rpm , Temperature control ... capacity of four 35 x 150mm bottles, eight ... , Consistent, repeatable results achieved with microprocessor ...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Medicine Products: