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One-Year Data From Global Atrial Fibrillation (AF) Registry Show Antithrombotic Agents Not Optimally Used to Prevent Stroke
Date:9/3/2013

sented at ESC Congress 2013 are from the first of five GARFIELD cohorts.  The first cohort includes a total of 10,614 patients with non-valvular AF and at least one investigator-determined additional risk factor for stroke, recruited from 540 randomly-selected sites in 19 countries. Of these patients, 5,089 were recruited retrospectively as a validation cohort and 5,525 were recruited prospectively and comprise the study populations in these abstracts.  ESC Guidelines for the management of atrial fibrillation recommend that all patients at high risk of stroke be prescribed anticoagulation therapy with vitamin K antagonists (VKAs), unless contraindicated. High stroke risk is defined as a score >/=2 on the CHA2DS2-VASc risk score. Previously reported baseline data showed that in Cohort 1, 82.6% of patients had CHA2DS2-VASc >/=2 but only 62% of these patients received anticoagulant therapy.

Data for the stroke-risk stratification research presented at ESC Congress 2013 were available in 5,523 patients enrolled prospectively between December 2009 and October 2011. 

The 1-year data – which are preliminary and should be interpreted with caution – were included in one oral presentation and seven poster abstracts.  The oral presentation was featured at the State of the Art: Acute coronary syndromes - current guidelines and future prospects, a session that spotlighted the four highest-rated abstracts in this topic. 

Highlights of the data, which were adjusted for relevant confounding factors, include:

Oral Presentation

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