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Oncologists in the United States and Europe Indicate that Novel Chemotherapies Hold the Most Near-Term Promise for Improving Outcomes in Soft Tissue Sarcoma
Date:1/29/2013

BURLINGTON, Mass., Jan. 29, 2013 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that, although interviewed oncologists in the United States and Europe would like to see a future of personalized medicine targeting different soft tissue sarcoma subtypes, they believe that it is in fact novel chemotherapies that hold the most near-term promise for improving outcomes in this highly fragmented indication.

According to Niche Markets and Rare Diseases: Soft Tissue Sarcoma, the clinical pipeline for the disease is relatively sparse and chemotherapy remains the backbone of current treatment. Additionally, most late-stage research focuses on developing novel chemotherapeutic agents or new formulations of chemotherapy drugs with proven efficacy. There are only a few agents in Phase III clinical trials and the majority are chemotherapeutic agents, while considerably more therapies are in mid-stage development and, depending on data, regulators may be open to considering a filing based only on Phase II results.

Initial clinical trials typically position these agents in refractory populations, where the barrier to gaining regulatory approval is relatively low. However, expansion into first-line populations is underway for a number of novel agents in development. Decision Resources forecasts that four agents will launch for soft tissue sarcoma between now and 2018 – palifosfamide (Ziopharm's Zymaphos), eribulin (Eisai's Halaven), crizotinib (Pfizer's Xalkori) and Threshold Pharmaceuticals' TH-302.

"Although we believe that palifosfamide will gain approval for the treatment of soft tissue sarcoma, it will likely not have a significant impact on overall survival outcomes for patients, be
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SOURCE Decision Resources
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