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OncoSec Medical Reports Positive Preliminary Efficacy Results from Phase II Study of ImmunoPulse in Metastatic Melanoma Patients
Date:11/15/2012

e (ORR). One patient has a confirmed stable disease, and the second patient has a confirmed complete response of all treated and untreated lesions. Analysis of the safety data for the subjects analyzed confirms that intratumoral administration of DNA IL-12 with electroporation is safe and well-tolerated. No related adverse events reported were greater than grade 2, and were generally limited to transient pain related to electroporation treatment.

The preliminary results are being presented in a poster titled "Preliminary Analysis of a Phase II Trial of Intratumoral Delivery of Plasmid Interleukin-12  (pIL-12) with In Vivo Electroporation in Patients with Metastatic Melanoma." Dr. Adil Daud, principal investigator and co-director of melanoma research at the University of California San Francisco School of Medicine, is co-author.

These data are also being orally presented at a parallel scientific symposium, hosted by OncoSec, titled "Electrogenetherapy: Intralesional Immunotherapy Approach for Skin Cancers Using Electroporation." Drs. Adil Daud and Axel Hauschild will chair the event, which will be held on Thursday, November 15 from 6:00-7:00pm Barcelona time. The agenda is as follows:

- Application and Versatility of Electrogenetherapy – Dr. Richard Heller
- Clinical Experience: Case presentation and discussion of intralesional injection of plasmid interleukin-12 with electroporation – Dr. Adil Daud
- Immune correlates and biomarkers: Immune related responses following intralesional injection of plasmid interleukin-12 with electroporation – Dr. David Weiner and Dr. Edward Cha
- Outlook on intralesional immunotherapies for the treatment of metastatic melanoma – Dr. Adil Daud

Punit Dhillon, President and CEO of OncoSec Medical, commented, "We are encouraged to have observed at least one complete response based on the evaluable patients that have met the primary endpoint timeline, and we will continu
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SOURCE OncoSec Medical Inc.
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