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OncoMed Anti-Cancer Stem Cell Antibody OMP-21M18 Demonstrates Potent Activity in Preclinical Studies Against Human Colon Cancer Tumors Regardless of KRAS Mutation Status
Date:3/1/2011

of OncoMed Pharmaceuticals, where OMP-21M18 was discovered and is being developed.  OMP-21M18 was evaluated using OncoMed's proprietary xenograft tumor models established from primary human tumors.  These models are designed to be more directly representative of human tumors than the cell lines used in standard cancer research.

About Colorectal Cancer

According to the American Cancer Society, colorectal cancer is the second leading cause of cancer-related deaths in the United States.  Treatment for colon cancer typically includes surgery, and depending on the stage of disease, location and history of resistance to prior treatments, may incorporate radiation therapy, treatment with chemotherapeutic agents and/or targeted anti-cancer agents.  Up to forty percent of colorectal cancers contain mutated KRAS genes, which have proven to be insensitive to treatment with monoclonal antibodies, such as cetuximab (Erbitux®) or panitumumab (Vectibix™), that target the epidermal growth factor receptor (EGFR).  As a result, a significant need exists for additional agents, particularly those that may be combined with chemotherapy, which can address both wild type and KRAS mutant tumor types.

About OMP-21M18

OncoMed is currently evaluating OMP-21M18 in a Phase 1 single agent study of patients with advanced solid tumors and in multiple Phase 1b combination studies in patients with colon cancer, pancreatic cancer or non-small cell lung cancer.  Preliminary results from OncoMed's Phase 1 dose-escalating single-agent study of OMP-21M18 demonstrate evidence of disease control and tumor response as measured by RECIST criteria.  In addition, biomarker measurements show that OMP-21M18 is a potent inhibitor of Notch signaling.  Initial clinical data from this ongoing study were presented at the 22nd EORTC-NCI-AACR symposium on "Molecular Targets and Cancer Therapeutics" held November 16-19, 2010 in
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SOURCE OncoMed Pharmaceuticals, Inc.
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