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OncoMed Anti-Cancer Stem Cell Antibody OMP-21M18 Demonstrates Potent Activity in Preclinical Studies Against Human Colon Cancer Tumors Regardless of KRAS Mutation Status
Date:3/1/2011

REDWOOD CITY, Calif., March 1, 2011 /PRNewswire/ -- OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics that target cancer stem cells, today announced the publication of preclinical data demonstrating that its lead candidate, OMP-21M18, inhibits tumor growth and reduces cancer stem cell frequency when administered alone or in combination with chemotherapy in human colorectal cancer tumors with or without KRAS mutations.  This study was published in the March 1, 2011 issue of Cancer Research, a publication of the American Association of Cancer Research.

"Using xenograft models developed at OncoMed, we observed that OMP-21M18 is equally efficacious against colon tumors with oncogenic KRAS mutations and colon tumors with a normal KRAS gene.  In contrast, cetuximab was inactive against KRAS mutant tumors," said Timothy Hoey, Ph.D., Senior Vice President, Cancer Biology of OncoMed Pharmaceuticals and a co-author of the paper.  "Further, OMP-21M18 was seen to reduce cancer stem cell frequency while promoting apoptosis in tumor cells and this activity was greatly enhanced when our agent was combined with chemotherapy.  These findings suggest that OMP-21M18 demonstrates potent anti-cancer activity in xenograft models of colorectal cancer with the potential to be an important treatment for this disease."

OMP-21M18 is a monoclonal antibody that blocks Delta-like 4 ligand (DLL4), an activator of Notch signaling, a pathway known to be important in stem cells and cancer.  Blocking DLL4 results in broad-spectrum anti-tumor activity via multiple mechanisms, including inhibiting cancer stem cell growth, promoting cell differentiation and disrupting angiogenesis.  OncoMed researchers conducted a series of experiments using the company's proprietary xenograft models to examine the efficacy of anti-DLL4 antibodies in KRAS-mutated and normal colorectal tumors derived from patients.  Treatment with anti-DLL4 w
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SOURCE OncoMed Pharmaceuticals, Inc.
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