Navigation Links
OncoMed Anti-Cancer Stem Cell Antibody OMP-21M18 Demonstrates Potent Activity in Preclinical Studies Against Human Colon Cancer Tumors Regardless of KRAS Mutation Status
Date:3/1/2011

REDWOOD CITY, Calif., March 1, 2011 /PRNewswire/ -- OncoMed Pharmaceuticals, Inc., a company developing novel therapeutics that target cancer stem cells, today announced the publication of preclinical data demonstrating that its lead candidate, OMP-21M18, inhibits tumor growth and reduces cancer stem cell frequency when administered alone or in combination with chemotherapy in human colorectal cancer tumors with or without KRAS mutations.  This study was published in the March 1, 2011 issue of Cancer Research, a publication of the American Association of Cancer Research.

"Using xenograft models developed at OncoMed, we observed that OMP-21M18 is equally efficacious against colon tumors with oncogenic KRAS mutations and colon tumors with a normal KRAS gene.  In contrast, cetuximab was inactive against KRAS mutant tumors," said Timothy Hoey, Ph.D., Senior Vice President, Cancer Biology of OncoMed Pharmaceuticals and a co-author of the paper.  "Further, OMP-21M18 was seen to reduce cancer stem cell frequency while promoting apoptosis in tumor cells and this activity was greatly enhanced when our agent was combined with chemotherapy.  These findings suggest that OMP-21M18 demonstrates potent anti-cancer activity in xenograft models of colorectal cancer with the potential to be an important treatment for this disease."

OMP-21M18 is a monoclonal antibody that blocks Delta-like 4 ligand (DLL4), an activator of Notch signaling, a pathway known to be important in stem cells and cancer.  Blocking DLL4 results in broad-spectrum anti-tumor activity via multiple mechanisms, including inhibiting cancer stem cell growth, promoting cell differentiation and disrupting angiogenesis.  OncoMed researchers conducted a series of experiments using the company's proprietary xenograft models to examine the efficacy of anti-DLL4 antibodies in KRAS-mutated and normal colorectal tumors derived from patients.  Treatment with anti-DLL4 w
'/>"/>

SOURCE OncoMed Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. OncoMed Chooses SynCo Bio Partners to Fill and Finish its Lead Antibody
2. SynCo Expands Agreement with OncoMed Pharmaceuticals to Manufacture Cancer Stem Cell Antibodies
3. Bayer and OncoMed Pharmaceuticals Enter Strategic Alliance to Develop Anti-Cancer Stem Cell Therapeutics
4. OncoMed Pharmaceuticals Awarded Five Therapeutic Discovery Project Grants Totaling $1.2 Million
5. OncoMed Pharmaceuticals Initiates Phase 1 Clinical Trial of Anti-Cancer Stem Cell Therapeutic OMP-59R5
6. Telik Announces Preclinical Data Demonstrating Anti-Cancer Activity of Dual Inhibitors of Aurora Kinase and VEGFR2
7. Preclinical Studies Show Potential Progress Toward Identifying Specific Tumor Types With Higher Likelihood of Demonstrating Response to Anti-Cancer Compounds Early in Clinical Development
8. Coley Pharmaceutical Group and Pfizer Nominate Additional Anti-Cancer Compound for Clinical Development
9. Aida Announces Completion of Anti-Cancer Drug Phase Two Testing
10. Celator(R) Pharmaceuticals Reports CPX-351 Shows Anti-Cancer Activity in Leukemia Patients
11. Clinical Experience With Peregrines Anti-Cancer Agent Bavituximab Presented at Leading Symposium on Anti-Angiogenic Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2015)... 2015 Research and ... of the "Investigation Report on China,s Latanoprost ... Developed by Pharmacia & Upjohn in 1995, ... effectively reduces intraocular pressure. As the first pressure- ... trade name of Xalatan) entered China ...
(Date:8/28/2015)... Perrigo Company plc ("Perrigo") (NYSE: PRGO ... (NASDAQ: MYL ) shareholder vote regarding its planned ... of Mylan,s offer to Perrigo shareholders have always been, ... careful reflection of the value available to Perrigo shareholders, ... Mylan has allowed its shareholders to consider," said ...
(Date:8/28/2015)... SEOUL, South Korea , Aug. 28, 2015 /PRNewswire/ ... Chungbuk National University and Dr. Ra from Biostar ... , Confirmed 30% increase of lifespan through multiple ... cognitive function, physical vitality, and life expectancy found ... Researchers in Korea have determined the possibility that adult ...
Breaking Medicine Technology:China Latanoprost Market Investigation Report 2015-2019 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 2Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 3Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 4Perrigo Confident Its Shareholders Will Reject Mylan's Value Destructive Transaction 5Korean Researchers Find the Possibility that Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan 2
... Inc. (Nasdaq: CRTX ) today announced that it ... Thursday, November 4, 2010, to discuss its financial results for ... results are expected to be released on Thursday, November 4, ... in the live conference call, please dial 866-804-6927 (U.S. callers) ...
... See video from AstraZeneca at: ... Anglo-Swedish pharmaceutical company AstraZeneca announced that revenue ... at constant exchange rates (CER) to $7,898 ... for Crestor, Symbicort and Seroquel XR. Revenue ...
Cached Medicine Technology:Cornerstone Therapeutics to Host Third Quarter 2010 Conference Call 2Cornerstone Therapeutics to Host Third Quarter 2010 Conference Call 3
(Date:8/30/2015)... ... ... Scientists in France say asbestos exposure may put workers at higher risk for ... posted an article on the new research. Click here to read it now. ... French asbestos plant workers from 1978 to 2009. In addition to mesothelioma, the workers ...
(Date:8/30/2015)... Fl (PRWEB) , ... August 30, 2015 , ... ... Executive Vice President Jeff Fernandez will lead the expansion of global cosmeceutical and ... and skin care experience having spent the last 25 years working in operations, ...
(Date:8/29/2015)... AZ (PRWEB) , ... August 30, 2015 , ... On ... College (EMCC), one of the 10 regionally accredited Maricopa Community Colleges , ... to network with college students pursuing employment information and opportunities. , The Expo has ...
(Date:8/29/2015)... ... August 29, 2015 , ... ... scrotal support and protection against dribbled urine and sweat. "In order to prevent ... N.Y. , The EASY ACCESS DRYNESS ENHANCED MEN'S UNDERGARMENT provides optimal support for ...
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor Day weekend, the ... ends on September 22nd this year). For IT security personnel, it should also mark ... could prove far more costly than a simple headache. , Joe Caruso, founder and ...
Breaking Medicine News(10 mins):Health News:Researchers Say Mesothelioma Not the Only Cancer Linked with Asbestos Exposure, According to Surviving Mesothelioma 2Health News:NPI Executive Vice President Leads Cosmeceutical Expansion 2Health News:Estrella Mountain Community College Expo Offers ‘One-Stop’ for Employers and Students Seeking Internships, Jobs, Careers and Service Learning Opportunities 2Health News:Modified Men’s Underwear Promote More Comfort and Hygiene - Designed by InventHelp Client (LGI-1968) 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4
... true personality, study finds , FRIDAY, Dec. 4 (HealthDay News) ... as Facebook, reveal the real you? The odds are good ... people tend to express their true selves instead of idealized ... the widely held assumption is that people are using their ...
... PHACTS, LLC, ... Health Systems and hospitals valued at $22.4 million in new business. PHACTS expects this number ... ... LLC, a leader in Pharmacy Inventory Management Systems, signed exclusive agreements in 2009 with USA ...
... 4 , ,What: Humana ( http://www.humana.com ), Florida,s largest Medicare, ... ( http://humanagames.com ), a senior-friendly dance ... Guidance Center on Tues., Dec. 8 ... free and open to the public, will feature Dancetown, ...
... W.Va., Dec. 4 UniCare Health Plan of West ... Corporation will be holding the second-annual Circle of ... including 2006 World,s Strongest Man Phil Pfister, Pro Bass ... Governor and Mrs. Manchin will participate in the two-day ...
... , , OKLAHOMA CITY, Dec. 4 ... for the first quarter ended September 30, 2009, a 24% decrease ... income for the quarter were $133,681 and $80,402, respectively, each a ... impacted by a decrease in pharmacy sector sales. This trend ...
... dramatic weight loss can be an effective way to improve ... university Karolinska Institutet report. Those with severe sleep apnoea when ... "Our findings suggest that weight loss may be an effective ... Johansson, one of the researchers involved in the study. ...
Cached Medicine News:Health News:Online Identities Likely to Match Reality 2Health News:PHACTS Receives $22.4 Million in New Business Commitments 2Health News:Humana Launches Dancetown on Tues., Dec. 8 in Kissimmee 2Health News:UniCare, Walmart Organize Circle of Hope To Help Mountain Mission Meet Increased Demand for Assistance 2Health News:PD-Rx Pharmaceuticals, Inc. Reports 1st Quarter Earnings 2Health News:Weight-loss proves effective cure for sleep apnea 2Health News:Weight-loss proves effective cure for sleep apnea 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: