Navigation Links
OncoGenex Expands Clinical Development of OGX-427 with a Phase 1 Clinical Trial in Bladder Cancer
Date:8/13/2009

samples after treatment allows us to demonstrate inhibition of Hsp27 expression at the cellular level in the tumor," said Scott Cormack, President and Chief Executive Officer of OncoGenex.

"By conducting this trial through an investigator-sponsored trial with leading clinical researchers at the Vancouver Prostate Centre allows us to advance the development of OGX-427 without a significant commitment of our financial resources," Cormack added.

In preclinical studies conducted by the Vancouver Prostate Centre, OGX-427 had single-agent activity in multiple cancers. In preclinical models of bladder cancer, the investigators observed that bladder cancer tumors were significantly smaller six weeks after OGX-427 administration compared to the control group.

About OGX-427

OGX-427 is designed to reduce production of Hsp27, a protein that is over-produced in response to many cancer treatments including hormone ablation therapy, chemotherapy and radiation therapy. Hsp27 production has been shown to inhibit cell death in tumor cells through a variety of mechanisms.

OGX-427 is being evaluated in another Phase 1 clinical trial for the systemic (intravenous) treatment of solid tumors including prostate, non-small cell lung, breast, ovarian, and bladder cancers. OncoGenex Pharmaceuticals, Inc. recently announced preliminary results of this Phase 1 trial presented during an oral presentation at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting. Results as of May 2009 showed that OGX-427 was well tolerated as a monotherapy. In addition, after treatment with OGX-427 patients experienced declines in circulating tumor cells at all doses evaluated as well as evidence of reduction in tumor markers. Reductions in circulating tumor cells and tumor markers both suggest single-agent activity warranting further clinical investigation.

Similar to OGX-011, OGX-427 has potential as a treatment in a broad number o
'/>"/>

SOURCE OncoGenex Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3 4

Related medicine technology :

1. Biodel Inc. Expands Ongoing Phase III VIAject(TM) Clinical Trials Into Europe
2. BiPar Expands Management Team to Advance Lead PARP Inhibitor Product Candidate Into Phase 2 Trials for Cancer
3. Cellectar Expands Clinical Management Team
4. VIA Pharmaceuticals Expands Clinical Trial Program for VIA-2291 in Acute Coronary Syndrome
5. PAREXEL Expands Late Phase Clinical Research Services and Appoints Leading Pharmacoepidemiology Expert Victor Kiri
6. Millennium Expands VELCADE(R) (Bortezomib) For Injection Program In Non-Hodgkins Lymphoma
7. PAREXEL Expands Global Clinical Pharmacology Capabilities
8. BiPar Sciences Expands Clinical Program for BSI-201, a Novel DNA Repair Inhibitor, in Brain Cancer
9. Senesco Expands on Recently Announced Preclinical Pancreatic Islet Data
10. Alseres Pharmaceuticals Expands Sites for the First Stage of the ALTROPANE(R) Phase III Clinical Trial Program
11. Delcath Expands Phase III Trial for Metastatic Melanoma to Include University of Maryland Medical Center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/17/2013)... , May 17, 2013  ConvaTec today announced that it will report ... Ken Berger , CEO, and Ed Borkowski , ... live via telephone. To participate in the conference call ... To participate in the conference call outside the U.S. and ... conference ID is 72195398. Participants should dial in 10 minutes ...
(Date:5/17/2013)... Fla. , May 17, 2013 Fuse Science, ... delivery technology company that is developing new, patent-pending technologies poised ... announced today that it will hold a business update teleconference ... May 22 nd , 2013 at 4:30 PM ET. ... will host the call and will be joined ...
(Date:5/17/2013)...  Atossa Genetics, Inc. (NASDAQ: ATOS ), The ... , Chief Financial Officer & General Counsel, will present ... May 30, 2013, in New York City ... Company,s presentation is scheduled to begin at 3:30 p.m. EDT ... the webcast, go to www.atossagenetics.com . For ...
Breaking Medicine Technology:Fuse Science, Inc. to Hold Business Update Webcast and Teleconference on May 22nd 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 2Atossa Genetics to Present at the Second Annual Marcum LLP MicroCap Conference 3
... May 27, 2011 CVS Caremark Corporation (NYSE: ... awarded a three-year contract to provide integrated pharmacy benefit ... Service Benefit Plan, also known as the Federal Employee ... Company will continue to provide FEP,s clinical programs and ...
... Kluwer Health today announced that it has completed the ... information and clinical content for pharmacists, clinicians and hospitals ... of strategic acquisitions Wolters Kluwer Health has made in ... strong focus on the point-of-care market. ...
Cached Medicine Technology:CVS Caremark Awarded Integrated 3-Year Blue Cross and Blue Shield Federal Employee Program (FEP) Contract 2Wolters Kluwer Health Completes Acquisition of Lexi-Comp, Inc. 2Wolters Kluwer Health Completes Acquisition of Lexi-Comp, Inc. 3
(Date:5/19/2013)... Alonso Krangle LLP a dedicated law firm , ... on behalf of a-24-year-old financial analyst rendered quadriplegic as a ... accident lawsuit, which was filed in the Supreme Court for ... the property out as a bathing beach, but posted absolutely ... No. 34556/12) , According to the diving accident lawsuit complaint, ...
(Date:5/19/2013)... Seven-year-old Torin Phillips and his 6-year-old sister, Kaia, ... of autism. The two siblings, who live just outside ... therapy (ABA) from the Center for Autism and ... effective treatment centers using evidence-based, state-of-the-art therapy. , At ... answer to his name, and had little interest in ...
(Date:5/19/2013)... May 19, 2013 Daily Gossip reporters have ... 17 Cheat Foods That Burn Fat to a close ... , The review is a detailed explanation ... the writer's recommendation. , The two nutritionists have discovered during ... responsible for the caloric intake and expenditure of our body, ...
(Date:5/19/2013)... GA (PRWEB) May 19, 2013 ... the National Council of Asian Pacific Physicians (NCAPIP), ... of the National Association of Chronic Disease Directors ... status of health systems, diabetes, and non-communicable diseases ... , The assessment, published in the Hawaii Journal ...
(Date:5/19/2013)... Although spring arrived late this year in parts of ... be strong, according to a sinus expert at the ... clinical professor in the university,s division of otolaryngology, said ... allergy season. However, some simple strategies can help people ... added. "Tree pollen has been bad for several ...
Breaking Medicine News(10 mins):Health News:Alonso Krangle Files Diving Accident Lawsuit on Behalf of Suffolk County Man Rendered Quadraplegic in Tragic Diving Accident at Long Island Beach 2Health News:Alonso Krangle Files Diving Accident Lawsuit on Behalf of Suffolk County Man Rendered Quadraplegic in Tragic Diving Accident at Long Island Beach 3Health News:Boston Brother and Sister Battle Odds to Overcome Autism with Help from Center for Autism and Related Disorders 2Health News:Boston Brother and Sister Battle Odds to Overcome Autism with Help from Center for Autism and Related Disorders 3Health News:Boston Brother and Sister Battle Odds to Overcome Autism with Help from Center for Autism and Related Disorders 4Health News:The "17 Cheat Foods That Burn Fat" Review and Diet Plan Secrets Revealed by Daily Gossip 2Health News:Pacific Island Public Health Group Declares Diabetes at Pandemic Proportions 2Health News:Pacific Island Public Health Group Declares Diabetes at Pandemic Proportions 3Health News:Managing Seasonal Allergies 2
... replacement care, according to Dr. Xueya Cai and colleagues ... work, published online in Springer,s journal Clinical Orthopaedics and ... likely than Caucasians to receive total knee arthroplasty (or ... is widely performed in patients of all races with ...
... , TUESDAY, Sept. 13 (HealthDay News) --,Two decades after the ... abnormalities in their brains that in some cases have even ... part of a debilitating disorder known as Gulf War illness. ... to be caused by exposure to neurotoxins and nerve gas. ...
... study finds that infections following cardiac device implantations or ... in terms of patient mortality, even months after affected ... led to 4.8 to 7.7-fold increases in admission mortality, ... 4.0-fold increases in hospital length of stay, and 1.4 ...
... Chicago Many patients are responding to a new, ... out the bad cells. Atrial fibrillation (A-Fib) is one ... arrhythmia affecting Americans. However, new research shows that 70 ... with cryoballoon ablation, the freezing technique, are free of ...
... Steele HealthDay Reporter , MONDAY, Sept. 12 ... help people with mild memory problems or early Alzheimer,s ... small study suggests. But, the study authors added, ... therapy will actually benefit patients. Alzheimer,s disease, the ...
... WINSTON-SALEM, N.C. September 12, 2011 A year ... listening to doctor,s orders when it comes to taking ... of Wake Forest Baptist Medical Center shows. However, there ... "Medication non-compliance is a major risk factor for stroke ...
Cached Medicine News:Health News:Does race dictate quality of care? 2Health News:Brain Blood Flow Abnormalities Persist in Gulf War Vets 2Health News:Costs, mortality skyrocket following infection in cardiac device recipients 2Health News:Freeze and desist: Disabling cardiac cells that can cause arrhythmia 2Health News:Insulin Spray May Improve Alzheimer's Symptoms 2Health News:Insulin Spray May Improve Alzheimer's Symptoms 3Health News:Researchers focus on secondary stroke prevention after study reveals room for improvement 2Health News:Researchers focus on secondary stroke prevention after study reveals room for improvement 3Health News:Researchers focus on secondary stroke prevention after study reveals room for improvement 4
... evanescent wave imaging system utilizes an ... in the thin section in contact ... This unique design permits simultaneous mounting ... systems, with no restriction on their ...
... color imaging camera system designed for ... performance, megapixel digital cameras provides high-resolution, ... them on a PC via its ... "live" previewing capability is accompanied by ...
... Tech GT-Capture digital camera photomicrographic system can ... such as Olympus, Leica, Nikon, and Zeiss, ... transferring images over the Internet easy and ... a performance-proven Nikkor lens. The system records ...
... Digital camera systems for optimum image quality ... low light, color digital camera system is ... light is available. State-of-the-art electronics create bright, ... The high dynamic range offered by the ...
Medicine Products: