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Omthera Pharmaceuticals Presents Data From Analysis Of EVOLVE Trial Showing That Epanova Lowers ApoC-III, A Key Predictor of Cardiovascular Risk
Date:11/9/2012

uctions in TG of 26% (p=0.003) in the 2g cohort and 31% (p<0.001) among patients in the 4g cohort, compared to 4% for olive oil. There was also statistically significant reduction in Non-HDL-C in all dose groups, with decreases in Non-HDL-C of approximately 8% (p<0.05) in the 2g cohort and 10% (p<0.01) in the 4g cohort. Non-HDL-C is widely viewed as the most accurate predictor of cardiovascular disease.  Reductions in ApoC-III were associated with the expected increase in HDL-C with an increase conversion of VLDL to LDL leading to an increase in LDL-C.  There was also an increase in LDL particle size.  Independent studies suggest that Omega-3 fatty acid formulations containing DHA alone, decrease TG and VLDL-C levels and increase LDL-C levels in patients with severe hypertriglyceridemia and that those containing EPA alone, lower triglycerides (TG) to a similar extent as EPA and DHA, but also fail to lower ApoC-III.  

Commenting on these results, Dr. Davidson noted, "ApoC-III represents a key link between hypertriglyceridemia and the probability of coronary events. We are therefore highly encouraged by the data from this analysis of the EVOLVE trial, which shows the unique effects of Omega-3 products containing both EPA+DHA, like Epanova, on this important marker of cardiovascular risk. These findings highlight the importance of incorporating both EPA and DHA in patient therapy to provide comprehensive risk management for those with hypertriglyceridemia." 

About Epanova™
Epanova is a patent protected, novel, ultra-pure mixture of the free fatty acid forms of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Omthera has developed a substantial body of data on Epanova, which points to an improved and more predictable bioavailability as compared to the ethyl ester form found in prescription Omega‐3 products currently available. Triglyceride, as well as Non-HDL-C lowering with Epanova was recently
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SOURCE Omthera Pharmaceuticals, Inc.
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