Navigation Links
Omeros Unlocks Orphan GPCRs Linked to Pancreatic Cancer and Cognitive Disorders
Date:3/2/2011

ets of compounds that interact selectively with five orphan receptors linked to squamous cell carcinoma (GPR87), pancreatic cancer (GPR182), obesity (GPR85), appetite control (GPR101) and cognitive disorders (GPR12). The CRA detects receptor antagonists and agonists. Antagonists comprise the majority of marketed drugs, and all of the compounds identified so far by Omeros are antagonists.

About G Protein-Coupled Receptors

GPCRs, which mediate key physiological processes in the body, are one of the most valuable families of drug targets. According to Insight Pharma Reports, GPCR-targeting drugs represent 30 to 40 percent of marketed pharmaceuticals. Examples include Claritin® (allergy), Zantac® (ulcers and reflux), OxyContin® (pain), Lopressor® (high blood pressure), Imitrex® (migraine headache), Reglan® (nausea) and Abilify® (schizophrenia, bipolar disease and depression) as well as all other antihistamines, opioids, alpha and beta blockers, serotonergics and dopaminergics.  

The industry focuses its GPCR drug discovery efforts mostly on non-sensory GPCRs. Of the 363 total non-sensory GPCRs, approximately 240 have known ligands (molecules that bind the receptors) with nearly half of those targeted either by marketed drugs (46 GPCRs) or by drugs in development (about 70 GPCRs). There are approximately 120 GPCRs with no known ligands, which are termed "orphan GPCRs." Without a known ligand, drug development for a given receptor is extremely difficult.

Omeros uses its proprietary high-throughput CRA to identify small-molecule agonists and antagonists for orphan GPCRs, unlocking them to drug development. Omeros believes that it is the first to possess the capability to unlock orphan GPCRs in high-throughput, and that currently there is no other comparable technology. Unlocking these receptors could lead to the development of drugs that act at these new targets. There is a broad range of indicatio
'/>"/>

SOURCE Omeros Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Omeros Announces Initiation of Patient Enrollment in OMS201 Phase 1 Study
2. Omeros Announces Publication of Clinical Results for OMS103HP in Arthroscopy: The Journal of Arthroscopic and Related Surgery
3. Omeros Announces Patient Enrollment in Phase 1/Phase 2 Study of OMS302
4. Omeros and The Parkinsons Institute and Clinical Center Enter into a Collaboration Agreement to Evaluate Novel Target for the Treatment of Movement Disorders
5. Omeros Receives $3.1 Million Milestone Payment from The Stanley Medical Research Institute for Schizophrenia Program
6. Omeros Prices Initial Public Offering of Common Stock at $10.00 Per Share
7. Omeros Announces National Institute on Drug Abuses Support for Phase 2 Clinical Study in Addiction Program
8. Omeros Corporation to Host Third Quarter 2009 Financial Results Conference Call on November 19
9. Daniel K. Spiegelman Elected to Board of Directors of Omeros
10. Omeros Reports Additional Phase 2 Data Showing Multiple Clinical Benefits In Patients Undergoing Meniscectomy Surgery
11. Omeros Selects Clinical Candidate for MASP-2 Program With Potential Applicability to Multiple Inflammatory Disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/1/2015)... N.C. , May 1, 2015  An ... that can provide non-binding but informed guidance to ... the return on investment, it is important for ... invest optimal resources. Research and ... study to assist pharmaceutical and medical device executives ...
(Date:5/1/2015)... N.C. , May 1, 2015 The ... for its high price but manufacturer Gilead Sciences overcame ... worldwide pricing, and effective public relations campaigns. ... of less severe side effects propelled the drug to ... 2014, the therapy,s first quarter on the market. But ...
(Date:5/1/2015)... BOSTON , May 1, 2015   Intarcia ... James P. Brady as Vice President, Human Resources, ... President and CEO. As a new key member of ... with the CEO and Leadership Team to assure the ... talent, and further embeds its core values and its ...
Breaking Medicine Technology:New Study Presents Insights to Advisory Board Effectiveness in the Pharmaceutical Sector 2New Study Examines Success Lessons of Sovaldi's and Harvoni's Blockbuster Launches 2Intarcia Appoints James P. Brady Vice President, Human Resources 2Intarcia Appoints James P. Brady Vice President, Human Resources 3Intarcia Appoints James P. Brady Vice President, Human Resources 4
(Date:5/3/2015)... Burnsville MN (PRWEB) May 03, 2015 ... in workplace safety solutions, announces its appearance at the ... Health Conference. Products that HealthPostures will exhibit at the ... Largest of the sit stand solutions is the 6100 ... push button height control, an adjustable keyboard tray, extended ...
(Date:5/2/2015)... ProText Kinetic 2 is a set of ... Pro X. ProText Kinetic 2 features 40 animation ... Pro X . Easily create interactive text videos without ... ProText Kinetic 2. , Using ProText Kinetic is as easy ... Kinetic presets in the FCPX timeline. Playback the default ...
(Date:5/2/2015)... (PRWEB) May 02, 2015 Kare Visits LLC. ... support for busy caregivers. Kare Visits offers relief for ... assisted living facilities. According to the Caregiver Action ... an average of 20 hours a week caring for an ... the cost to hire a nurse, a caregiver is now ...
(Date:5/1/2015)... Islands, BWI (PRWEB) May 02, 2015 ... It is http://www.thevenetiangracebay.com , and it is ... incorporates the stunning white and attractive turquoise hues of ... of Google, sixty seven percent of leisure travelers used ... showed that smartphones were used in the planning and ...
(Date:5/1/2015)... TROY Healthcare Solutions is proud to ... Group (RUG) Conference in Atlanta, GA from May 6 ... Conference provides a forum for client-to-client presentations, continuing education ... of electronic medical record operations, as well as showcasing ... In addition to sponsoring the event, TROY Healthcare Solutions ...
Breaking Medicine News(10 mins):Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 2Health News:HealthPostures to Appear at the Minnesota Safety and Health Conference 3Health News:Pixel Film Studios Announced the Release of Protext Kinetic 2 for FPCX. 2Health News:Chicagoan Seeks to Transform Industry by Launching an Innovative Elderly Care Solution 2Health News:Turks and Caicos Resort, The Venetian on Grace Bay, Launches New Web Presence 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner Southeast Regional User Group Conference 3
... with Leading Integrated Delivery Systems, Telehealth Pioneer ATI is Transforming Care ... to Expert Care 24/7/365 , ... Irvine, Calif., and ... on newsstands now, Entrepreneur magazine named American TeleCare, Inc. (ATI) as ...
... Brand to Debut ,Passionately Pink, Apparel Collection, Donate $250,000 and ... Hanes (R) today announced it is ... and actress Sarah Chalke to join the fight against breast ... Official Apparel Sponsor of Passionately Pink for the Cure, a ...
... May 27 Endocare, Inc. (Nasdaq: ENDO ... development of minimally invasive technologies for tissue and tumor ... Company received a letter from The NASDAQ Stock Market ... for the period ended March 31, 2009, NASDAQ has ...
... Nepstar Chain,Drugstore Ltd. (NYSE: NPD ) ("Nepstar" ... on the number of directly operated stores, today,announced its ... 31,2009. , Financial Highlights , ... of directors approved the termination of,a voting rights assignment ...
... Edition Offers Up-to-the-Minute Clinical Guidance , ... Philadelphia, PA ... (LWW) today announced the release of a groundbreaking, print-and-electronic edition ... LWW is part of Wolters Kluwer Health , a ...
... especially the middle-aged, to adopt healthier lifestylesCHARLESTON, S.C., May ... eating a diet high in fruits and vegetables, maintaining ... only a small proportion of adults follow this healthy ... according to a study by Dana King, M.D., and ...
Cached Medicine News:Health News:Entrepreneur Magazine Names American TeleCare, Inc. (ATI) One of the Nation's 100 Brilliant Companies to Watch in 10 Hot Industries 2Health News:Entrepreneur Magazine Names American TeleCare, Inc. (ATI) One of the Nation's 100 Brilliant Companies to Watch in 10 Hot Industries 3Health News:Hanes(R) Teams up with Susan G. Komen for the Cure(R) and Actress Sarah Chalke to Comfort Those Affected by Breast Cancer 2Health News:Hanes(R) Teams up with Susan G. Komen for the Cure(R) and Actress Sarah Chalke to Comfort Those Affected by Breast Cancer 3Health News:Hanes(R) Teams up with Susan G. Komen for the Cure(R) and Actress Sarah Chalke to Comfort Those Affected by Breast Cancer 4Health News:Hanes(R) Teams up with Susan G. Komen for the Cure(R) and Actress Sarah Chalke to Comfort Those Affected by Breast Cancer 5Health News:Endocare Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 2Health News:Endocare Receives NASDAQ Deficiency Letter Regarding Stockholders' Equity 3Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 2Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 3Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 4Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 5Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 6Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 7Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 8Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 9Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 10Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 11Health News:China Nepstar Chain Drugstore Reports First Quarter 2009 Financial Results 12Health News:Companion Website and Podcasts Enhance New, Sixth Edition of Clinical Anesthesia 2Health News:Companion Website and Podcasts Enhance New, Sixth Edition of Clinical Anesthesia 3Health News:The Age of Good Health? Healthy Lifestyles on Decline in U.S. 2Health News:The Age of Good Health? Healthy Lifestyles on Decline in U.S. 3
... Harmony Special Peristaltic phacoemulsification system features microprocessor ... individual programmability and remote control for all ... front panel with color coded function modes ... ease of use and viewing. Under control ...
The D.O.R.C. Silicone Oil is an ultra purified silicone oil which leads a maximum interfacial tension and minimizes interactions between tissues, cells and endo-tamponades media. (Sterile, 10 ml.)...
Eftiar® offers the vitreoretinal surgeon a temporary tamponade for efficient re-attachment of the retina, release of subretinal fluid, dissection of fibro-vascular proliferation and controlling r...
Silver Foley Catheter 2-way...
Medicine Products: