Navigation Links
Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders
Date:6/27/2011

ontrol (GPR101), cognitive disorders (GPR12), sleep disorders (OPN4) and motor control (GPR139). The CRA detects receptor antagonists and agonists. Antagonists comprise the majority of marketed drugs, and all of the compounds identified so far by Omeros are antagonists.

About G Protein-Coupled Receptors

GPCRs, which mediate key physiological processes in the body, are one of the most valuable families of drug targets. According to Insight Pharma Reports, GPCR-targeting drugs represent 30 to 40 percent of marketed pharmaceuticals. Examples include Claritin® (allergy), Zantac® (ulcers and reflux), OxyContin® (pain), Lopressor® (high blood pressure), Imitrex® (migraine headache), Reglan® (nausea) and Abilify® (schizophrenia, bipolar disease and depression) as well as all other antihistamines, opioids, alpha and beta blockers, serotonergics and dopaminergics.  

The industry focuses its GPCR drug discovery efforts mostly on non-sensory GPCRs. Of the 363 total non-sensory GPCRs, approximately 240 have known ligands (molecules that bind the receptors) with nearly half of those targeted either by marketed drugs (46 GPCRs) or by drugs in development (about 70 GPCRs). There are approximately 120 GPCRs with no known ligands, which are termed "orphan GPCRs." Without a known ligand, drug development for a given receptor is extremely difficult.

Omeros uses its proprietary high-throughput CRA to identify small-molecule agonists and antagonists for orphan GPCRs, unlocking them to drug development. Omeros believes that it is the first to possess the capability to unlock orphan GPCRs in high-throughput, and that currently there is no other comparable technology. Unlocking these receptors could lead to the development of drugs that act at these new targets. There is a broad range of indications linked to orphan GPCRs including cardiovascular disease, asthma, diabetes, pain, obesity, Alzheimer's disease, Parkins
'/>"/>

SOURCE Omeros Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Omeros Reports Allowance of Additional Patent for Arthroscopic Product
2. Omeros Announces Clinical Development Programs for OMS103HP and OMS302
3. Omeros Corporation Reports First Quarter 2011 Financial Results
4. Omeros Announces Expansion of Potential Indications for PDE7 Inhibitors
5. Omeros Announces Publication of MASP-2 Data in Proceedings of the National Academy of Sciences
6. Omeros Reports Outcome of Phase 3 Trials of OMS103HP
7. Omeros Corporation Reports Fourth Quarter and Year-End 2010 Financial Results
8. Omeros Unlocks Orphan GPCRs Linked to Pancreatic Cancer and Cognitive Disorders
9. Omeros Announces Expansion of Exclusive License to PDE7 Inhibitors from Daiichi Sankyo
10. Omeros Announces Publication of Data From Antifibrinolytic Program
11. Omeros Licenses Novel Antifibrinolytic Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... - The Canadian Epilepsy Alliance (CEA) is thrilled to announce ... children about the most common neurological disorder in ... comic series tells a fictional story based on the experiences ... with epilepsy. "Despite the fact that epilepsy ... misinformation and lack of awareness out there," says Gail ...
(Date:8/21/2014)... , Aug. 21, 2014  IBM (NYSE: IBM ... ( DESY ), a leading national research center in ... and storage of massive volumes of x-ray data. The ... on IBM software defined technology can handle more than ... and help scientists worldwide gain faster insights into the ...
(Date:8/21/2014)... , Aug. 21, 2014  Zacks.com announces the list of ... Equity Research analysts discuss the latest news and events impacting ... blog include the Hewlett-Packard (NYSE: HPQ - Free Report ), ... Inc. (NYSE: SB - Free Report ), GlaxoSmithKline plc ... N.V. (NYSE: FI - Free Report ). ...
Breaking Medicine Technology:Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11
(Date:8/22/2014)... FL (PRWEB) August 22, 2014 This ... cell therapy research affiliate, Saneron CCEL Therapeutics, Inc. in ... , “Cryo-Cell is extremely pleased to collaborate with Saneron ... IND, which we hope will lead to regenerative ... diseases such as ALS,” David Portnoy, Chairman and Co-CEO ...
(Date:8/22/2014)... 2014 (HealthDay News) -- The air in American cities ... Agency reported Thursday. Significant progress has been made ... in recent decades, the agency said in a news ... 60 percent reduction in mercury from human sources such ... and an 84 percent fall in lead, which harms ...
(Date:8/22/2014)... may reduce addiction without increasing exposure to toxic ... University of Waterloo. , The study published ... the smoking behaviours of 72 adults as they ... reduced nicotine levels. , Unlike when smokers switch ... similar levels of nicotine contentthe study found no ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Goats are taking ... Milk Foods, attends the 10th annual Pre-Emmy Awards Boom Boom ... to try the best new products for kids on August ... 4 p.m., and we’ll be encouraging them to #GoGoat for ... so excited to present our gentle, non-GMO goat milk foods ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 For the ... employee reward and recognition industry, has received a prestigious ... extraordinary growth rate of 134%, TharpeRobbins remains on the ... North America. TharpeRobbins was previously on the list in ... to be included in this distinguished list for a ...
Breaking Medicine News(10 mins):Health News:Cryo-Cell Provides Funding for Cord Blood Clinical Trial Application to Treat ALS 2Health News:Cryo-Cell Provides Funding for Cord Blood Clinical Trial Application to Treat ALS 3Health News:Air in U.S. Cities Getting Cleaner, EPA Says 2Health News:Smokers consume same amount of cigarettes regardless of nicotine levels 2Health News:#GoGoat with Kabrita at the Pre-Emmy Awards Boom Boom Room 2Health News:For The Fourth Time - TharpeRobbins Earns A Place On Prestigious Inc. Magazine 500|5000 List 2Health News:For The Fourth Time - TharpeRobbins Earns A Place On Prestigious Inc. Magazine 500|5000 List 3
... July 9, 2009 The President of the ... statement today on President Obama,s nomination of Francis Collins, M.D., ... Health (NIH):,"At no other time in recent memory has there ... in the power of science to deliver solutions to the ...
... Bioheart, Inc. (OTC Bulletin Board: BHRT) (the "Company") ... July 7, 2009, Bioheart, Inc. (the "Company") has received proceeds ... common stock and warrants under its current offering under Regulation ... Common Stock to be issued in connection with the Offering ...
... Parsippany took top honors in the state,s first-ever 100-day ... on June 2nd. With participating residents losing an average of ... pounds, Parsippany was presented with a plaque and Morris County ... , Residents throughout northern and central New Jersey also participated ...
... , ... and Directory Helps Attendees and Exhibitors,Connect at AAMSE Conference and Beyond. , ... Arlington, VA (PRWEB) July 9, 2009 -- MarketArt ... enhanced attendee experience at the American Association of Medical Society Executives (AAMSE) 2009 ...
... Institute of Technology (Caltech) and the Scripps Research Institute have ... chemicals that have the potential to take the place of ... James R. Heath, the Elizabeth W. Gilloon Professor and ... M. Keck Professor of Chemistry at the Scripps Research Institute ...
... United States Senate Committee on Small Business ... Member Olympia J. Snowe, R-Maine, today convened a ... relate to small businesses. Participants at the roundtable, ... the Perspective of Small Businesses," included U.S. Sen. ...
Cached Medicine News:Health News:Bioheart, Inc. Announces Receipt of $2.8 Million in Proceeds From Pipe Financing 2Health News:Bioheart, Inc. Announces Receipt of $2.8 Million in Proceeds From Pipe Financing 3Health News:Parsippany Takes Top Honors in New Jersey's First-Ever Toxic Waistlines Contest 2Health News:Parsippany Takes Top Honors in New Jersey's First-Ever Toxic Waistlines Contest 3Health News:MarketArt to Enhance Attendee Experience at AAMSE Annual Conference 2Health News:MarketArt to Enhance Attendee Experience at AAMSE Annual Conference 3Health News:Caltech chemists say antibody surrogates are just a 'click' away 2Health News:Caltech chemists say antibody surrogates are just a 'click' away 3Health News:Landrieu, Snowe Convene Roundtable on Healthcare for Small Businesses 2Health News:Landrieu, Snowe Convene Roundtable on Healthcare for Small Businesses 3
Nature's Remarkable Skin Protector -- Karaya 5 is a natural skin barrier that is particularly well suited for skin problems or for sensitive skin where reactions may have occurred to other types of s...
Protects skin from corrosive drainage with the standard wear, FlexWear skin barrier. Security and confidence assured with porous tape, internal non-reflux valves, convenient drain valve....
Inquire...
Inquire...
Medicine Products: