Navigation Links
Omeros Unlocks Orphan GPCRs Linked to Leukemia and Sleep Disorders
Date:6/27/2011

SEATTLE, June 27, 2011 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it has identified compounds that interact with orphan G protein-coupled receptors (GPCRs) P2Y8 and OPN4. P2Y8 (also known as P2RY8) is associated with acute lymphoblastic leukemia (ALL), an aggressive cancer of the white blood cells. ALL is the most common type of malignancy diagnosed in children. The OPN4 receptor is involved with regulation of circadian rhythms, and could provide a target for drugs to improve alertness and to treat a wide range of sleep disorders ranging from narcolepsy and jet lag to insomnia.

Omeros has now announced that it has unlocked 10 of the 81 Class A orphan GPCRs. GPCRs represent the premier family of drug targets, with more than 30 percent of currently marketed drugs targeting only 46 GPCRs. There are approximately 120 orphan GPCRs, and Omeros, which expects to unlock a large percentage of these for drug development, is initially targeting Class A orphan GPCRs.

"The P2Y8 and OPN4 receptors are linked to important therapeutic areas that receive significant industry attention," said Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "By identifying compounds that interact with these two orphan receptors, our proprietary screening technology has opened previously closed drug-development pathways for ALL and sleep disorders."

Ongoing GPCR Program

Omeros has begun screening orphan GPCRs against its small-molecule chemical libraries using its proprietary, high-throughput cellular redistribution assay (CRA). Omeros has announced that it has identified and confirmed sets of compounds that interact selectively with 10 orphan receptors linked to squamous cell carcinoma (GPR87), pancreatic cancer (GPR182),acute lymphoblastic leukemia (P2Y8/P2RY8), metabolic and psychotic disorders(GPR27, GPR85, GPR173), appetite c
'/>"/>

SOURCE Omeros Corporation
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Omeros Reports Allowance of Additional Patent for Arthroscopic Product
2. Omeros Announces Clinical Development Programs for OMS103HP and OMS302
3. Omeros Corporation Reports First Quarter 2011 Financial Results
4. Omeros Announces Expansion of Potential Indications for PDE7 Inhibitors
5. Omeros Announces Publication of MASP-2 Data in Proceedings of the National Academy of Sciences
6. Omeros Reports Outcome of Phase 3 Trials of OMS103HP
7. Omeros Corporation Reports Fourth Quarter and Year-End 2010 Financial Results
8. Omeros Unlocks Orphan GPCRs Linked to Pancreatic Cancer and Cognitive Disorders
9. Omeros Announces Expansion of Exclusive License to PDE7 Inhibitors from Daiichi Sankyo
10. Omeros Announces Publication of Data From Antifibrinolytic Program
11. Omeros Licenses Novel Antifibrinolytic Agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. For the ... on the corporate reputation of the pharmaceutical industry held ... with the views of patient organisations representing all therapy ...
(Date:4/16/2015)... Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: VNDA ... commercialization of products for the treatment of central nervous ... the first quarter of 2015 on Wednesday, May 6, ... Company will host a conference call at 4:30 PM ... management will discuss the first quarter 2015 financial results ...
(Date:4/16/2015)...  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) will report ... Wednesday, May 6, 2015, following the close of the U.S. ... call and live webcast on the same day at 5:00 ... the financial results.  To access the webcast ... "Investors" link.  Please log onto the webcast prior to the ...
Breaking Medicine Technology:Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3Vanda Pharmaceuticals to Announce First Quarter 2015 Financial Results on May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 2Alexza to Report 2015 First Quarter Financial Results and Provide Corporate Update on Wednesday, May 6, 2015 3
... 2011 Unilife Corporation ("Unilife" or the "Company") (Nasdaq: ... be presenting at Cowen and Company,s 31st Annual Health Care ... Boston. Alan Shortall, Chief Executive Officer of Unilife, is scheduled ... 2011. The conference presentation will be broadcast over ...
... VICTOR, N.Y., March 7, 2011 PharmaNova, Inc. ... whereby Lacerta Bio,s experienced team of business development ... and U.K. to support its 2011 business growth ... PharmaNova,s partnering base for its innovative, nanoparticle technology, ...
Cached Medicine Technology:Unilife to Present at the 31st Annual Cowen Health Care Conference on Wednesday, March 9, 2011 in Boston 2PharmaNova Fuels Business Growth with Lacerta Bio Partnership 2
(Date:4/18/2015)... Lowcostcarinsuranceprice.com has released a new blog post explaining the ... prices . , Drivers who live in states ... to pay more for auto insurance plans that provide ... offer protection against vehicle theft. , Affordable auto ... single website: http://lowcostcarinsuranceprice.com/ . Drivers who own ...
(Date:4/18/2015)... More than 2000 styles of newly designed prom ... online store carrying celebrity inspired special occasion dresses. With ... perfect dresses for their prom. For those who are ... TheCelebrityDresses.com would be an ideal choice. , "We ... inspired by the most loved styles seen at this ...
(Date:4/18/2015)... 2015 French physician and gastronome Anthelme ... when he uttered, “Tell me what you eat, and ... to cope with stress or sadness has often been ... indicates otherwise. Data collected from their Emotional Eating ... emotional eating, but for different reasons. , Collecting data ...
(Date:4/17/2015)... California (PRWEB) April 17, 2015 ... Dr. Kevin Sadati of the Gallery of ... Orange County’s top beauty experts. The publication focused ... lift, facial stem cell fat grafting, eyelid surgery, laser ... facial plastic surgery has resulted in thousands ...
(Date:4/17/2015)... In Defense of Christians (IDC) Executive Director ... April 15th, the European Parliament joined its voice with ... Armenian Genocide, “paying tribute, on the eve of the ... Armenian victims who perished in the Ottoman Empire.” ... this timely and needed recognition of a tragic episode ...
Breaking Medicine News(10 mins):Health News:High Rates Of Car Theft Can Have An Impact on Auto Insurance Prices! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 2Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 3Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 4Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 5Health News:It’s Not Just A Girl Thing: Queendom Study Reveals That Men Struggle With Emotional Eating Too 6Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 2Health News:Orange County Facial Plastic Surgeon Featured in Premier Magazine Focused on Beauty 3Health News:In Defense of Christians Condemns Armenian Genocide 2Health News:In Defense of Christians Condemns Armenian Genocide 3
... 21st century mums are more likely,to turn to the ... less judged on their parenting skills than in other environments,new ... found that only 2% of mothers felt,judged by their online ... and other mums at the school gate. The findings mark ...
... 19 CorVel Corporation,(Nasdaq: CRVL ) today ... common stock under the stock repurchase program previously ... 2006, the Board had approved a,1,500,000 share expansion ... Company has repurchased 862,323 shares, with a remaining ...
... A pilot study from researchers at ... band imaging (NBI) colonoscopy used in cancer surveillance ... lesions. The research appears in the November issue ... of the American Society for Gastrointestinal Endoscopy. , ...
... 90% of people miss out on critical early treatment period, ... call them transient ischemic attacks, but they,re more commonly known ... be deadly. , What,s worse, many people who suffer such ... people who experienced symptoms of a transient ischemic attack (TIA) ...
... join Congressmen Ciro D. Rodriguez, Charlie Gonzalez, Henry ... Children,s Health,Insurance Program (SCHIP) bill that will provide ... Nancy Pelosi Congressman Ciro D. Rodriguez (TX-23) ... Cuellar (TX-28), WHAT: Rally for Children,s Health ...
... Improved Patient Privacy,Protections, LOS ANGELES, Nov. 16 ... Medical Association (AMA) for,recently updating its HIV testing ... improved protection of patient privacy. According,to a news ... Report, the,AMA,s new guidelines call for, "...physicians to ...
Cached Medicine News:Health News:Mums Go Online to Avoid Judgement 2Health News:CorVel Corporation Announces Resumption of Stock Repurchases 2Health News:CorVel Corporation Announces Resumption of Stock Repurchases 3Health News:Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients 2Health News:Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients 3Health News:Mini Strokes: Major Health Threats 2Health News:Mini Strokes: Major Health Threats 3Health News:AMA's New HIV Testing Guidelines Good for Public Health, Says AHF 2
The RU is a low profile implantable bipolar tined permanent pacing lead for stimulation of either the atrium (J model) or the ventricle (straight model)....
The Petite leads are low profile (4.8F lead body diameter) implantable endocardial pacing leads which are manufactured using a new proprietary hexafilar coil for permanent stimulation of the ventricl...
The Vitatron Excellence S+ lead series are endocardial leads providing excellent reliability and optimal pacing characteristics....
... Impulse II lead series are silicon ... extend the longevity of the pacemaker ... The high impedance of the lead ... electrode surface, combined with the elution ...
Medicine Products: