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Omeros Successfully Unlocks Orphan GPCRs
Date:6/29/2010

SEATTLE, June 29 /PRNewswire-FirstCall/ -- Omeros Corporation (Nasdaq: OMER) today announced that it has successfully identified compounds that interact with three orphan G protein-coupled receptors (GPCRs) linked to cancer, metabolic disorders and appetite control. This breakthrough demonstrates Omeros' unique capability to introduce a large number of new drug targets to the pharmaceutical industry, which could lead to the development of novel therapeutics across a wide range of diseases and disorders. GPCRs represent the premier family of drug targets, with more than 30 percent of currently marketed drugs targeting only 46 GPCRs. There are approximately 120 orphan GPCRs, and Omeros expects to unlock a large percentage of these for drug development.

"To my knowledge, Omeros' team is the first and only group to be able to unlock orphan GPCRs in high-throughput," stated Marc G. Caron, Ph.D., James B. Duke Professor of Cell Biology at Duke University. Dr. Caron is a leading expert in GPCRs and, together with his colleagues, was the first to purify and clone a GPCR. "I expect that this will result in a long line of wholly new and exciting drug targets, which will have a profound impact on the pharmaceutical industry," continued Dr. Caron.

"These initial successes in our GPCR program represent more than 10 years of hard work by our first-rate group of scientists, and I am immensely proud of what they have accomplished," stated Gregory A. Demopulos, M.D., chairman and chief executive officer of Omeros. "We plan to complete high-throughput screening of all orphan GPCRs and pursue a commercialization strategy focused on both par
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