Navigation Links
Omeros Reports Positive Results from OMS824 Positron Emission Tomography Clinical Trial
Date:5/31/2013

SEATTLE, May 31, 2013 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced positive results from its Phase 1 clinical program evaluating OMS824, the lead compound from its phosphodiesterase 10 (PDE10) program. This study measured the extent to which OMS824 binds to PDE10 in the basal ganglia, a region of the brain that has been linked to a wide range of diseases that affect cognition. The results show that the selected dose of OMS824 achieved approximately 50 percent occupancy of PDE10 without triggering the extrapyramidal symptoms (loss of muscle control, e.g., muscle rigidity, tremors, or involuntary muscle movements) reported as side effects with other PDE10 inhibitors that achieved similar or significantly lower occupancy levels. OMS824 is Omeros' proprietary compound that selectively inhibits PDE10, and the Company plans to advance into Phase 2 clinical trials in Huntington's disease and schizophrenia later this year.

The OMS824 Phase 1 clinical program previously evaluated the tolerability and pharmacokinetics of single and multiple doses of OMS824 in healthy subjects. OMS824 was well tolerated by all subjects, and the only apparent drug-related adverse event was mild somnolence at the highest dose evaluated. In the clinical trial reported today, positron emission tomography (PET) scans were used to measure the binding activity of OMS824 to PDE10 in the brains of healthy subjects who received once daily dosing of OMS824 for seven days.  Quantitation of PET images showed that approximately 50 percent occupancy of PDE10 in the basal ganglia was achieved by this dosing regimen. OMS824 was well tolerated and, consistent with earlier studies, mild somnolence was the only apparent adverse effect.

Other PDE10 inhibitors under development have been associated with extrapyramidal symptoms in humans at similar or substanti
'/>"/>

SOURCE Omeros Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Omeros to Present at Deutsche Bank Securities Health Care Conference
2. Omeros Adds Four More Unlocked Orphan GPCRs to its Portfolio
3. Omeros to Present at Jefferies 2012 Global Healthcare Conference
4. Omeros Announces Proposed Public Offering of Common Stock
5. Omeros Prices $30 Million Public Offering of Common Stock
6. Omeros Announces Closing of $34.5 Million Public Offering of Common Stock
7. Omeros Successfully Completes Preclinical Studies of OMS824 for Schizophrenia and Phase 1 Clinical Trial Preparations Underway
8. Omeros Announces Discovery in MASP-2 Program
9. Omeros Corporation Reports Second Quarter 2012 Financial Results
10. Omeros Announces Completion of Enrollment in OMS103HP Phase 3 Clinical Trial
11. Omeros to Present at Two Upcoming Conferences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... BOCA RATON, Fla. , Dec. 19, 2014 /PRNewswire/ ... entered into a multi-product agreement with MSN Laboratories Pvt. ... Breckenridge and MSN expect to commercialize several new ANDAs. ... manufacture, and supply the products exclusively to Breckenridge for ... the products under its label.  Breckenridge and MSN have ...
(Date:12/19/2014)... HILL, N.C. , Dec. 19, 2014 /PRNewswire/ ... to optimize a product,s web presence to reflect ... Brand websites, in particular, must meet the needs ... regulations and culture. According to ... more than half of the participating companies averaged ...
(Date:12/19/2014)... 2014  Monarch America Inc. (OTCQB: CANK) ("Monarch America" ... to provide this review of the Company,s recent achievements ... "Over this past year, we achieved many of ... proud to say that Monarch America is in a ... ever been," stated Eric Hagen , CEO of ...
Breaking Medicine Technology:Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Building a Best-in-Class Pharma Global Brand Website 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3
... 14, 2011  Heska Corporation (NASDAQ: HSKA ; ... and specialty products to veterinarians, announced today the intent ... expertise in blood-related disorders.  The parties are to explore ... cell-based therapeutics, for use in the veterinary market.      ...
... Group, Inc. (OTCMARKETS: UYMG) "UNITY" (or the "Company"), and its ... it has sold its initial PZ Uno Tablet press to ... the company is not able to disclose the name of ... tablet press would be used for a research and development ...
Cached Medicine Technology:Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 2Heska Announces Exploration of New Technologies Through Strategic Collaboration with Entegrion, Inc. 3Unity Management Group, Inc. Announces Its Initial Sale of the PZ UNO Tablet Press to a Major Pharmaceutical Company for $500,000 2
(Date:12/20/2014)... The print component of Healthy Aging is distributed ... 160,000 copies and an estimated readership of 420,000. The ... media strategy and across a network of top news ... of the campaign, click here . , The ... of CTV’s The Social. Lainey Lui, Melissa Grelo, ...
(Date:12/20/2014)... 2014 Angeldress.co.uk, the distinguished wedding dress ... worldwide dress fans. The company has recently updated its ... For the holiday season, Angeldress Blog has ... apparel. , Angeldress.co.uk prides itself in offering a huge ... service. All the company’s outfits are very carefully selected ...
(Date:12/20/2014)... Recently, AngelWeddingDress.com has introduced its special offer ... coming Christmas. In the promotion, all buyers worldwide can ... have something special for the women who are looking ... our new collections of 2015 dresses have been unveiled ... greatly discounted prices. Visit our website now before they ...
(Date:12/20/2014)... AZ (PRWEB) December 20, 2014 Parker ... professional technicians with years of experience in contractor services ... dedicated contractor services for the homeowners of Arizona. Parker ... team a professional contractor technicians that make customer service ... 1974 in Phoenix Arizona and started with one service ...
(Date:12/19/2014)... Sweetdressy.com , a leading wedding dress ... selection of cheap prom dresses for ladies worldwide. The ... world and clients can buy these dresses at the ... feature cool cuts and delicate craftsmanship, and most of ... market. Discount shipping costs are available for all of ...
Breaking Medicine News(10 mins):Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:Trendy Professional Wedding Apparel Recommended by Angeldress Blog 2Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 2Health News:Parker & Sons Announces Reaching A Milestone By Providing 40 Years Of Dedicated Contractor Services For Homeowners Of Arizona 3Health News:Cheap Prom Dresses Online Now at Sweetdressy.com 2
... odds , , MONDAY, May 25 (HealthDay News) -- ... with chemotherapy greatly increases the risk of gastrointestinal perforations ... perforations are potentially life-threatening holes in the wall of ... is designed to slow the growth of tumors by ...
... 25 /PRNewswire-Asia/ -- The general health of toddlers in,the ... conducted by the Hong,Kong Institute of Asia-Pacific Studies at ... a news conference today to announce the results, a ... paediatrician and a registered dietician,all agreed that, based on ...
... women should keep active while pregnant, experts say, , , SUNDAY, ... might be skeptical about exercising while she,s pregnant. So many ... have second thoughts about whether exercise might harm her or ... thoughtful exercise program is good for both mother and child, ...
... takes practice, on and off the field, experts say, ... do it safely, says the American Academy of Orthopaedic ... aged 5 to 14 were treated for baseball-related injuries ... settings, the U.S. Consumer Product Safety Commission notes. ...
... Texas Discovery Gardens at Fair Park, La Voz Del Anciano and El ... ... Amidst the radiant colorful beauty of the Texas Discovery Gardens at Fair ... Restaurant and the smartest and brightest youth from L.G. Pinkston High School ...
... develop a well produced audio or video for a internet ... of attracting clients. Jeff Fisher, the developer of ... than the written word can provide when selecting a therapist ... mental health professionals. It,s a new phenomenon that is ...
Cached Medicine News:Health News:Cancer Drug May Boost Risk of Gastrointestinal Perforation 2Health News:CUHK Releases Results of 'Survey on Toddler Health in Hong Kong' 2Health News:CUHK Releases Results of 'Survey on Toddler Health in Hong Kong' 3Health News:CUHK Releases Results of 'Survey on Toddler Health in Hong Kong' 4Health News:Mom and Baby Alike May Benefit From Exercise 2Health News:Mom and Baby Alike May Benefit From Exercise 3Health News:For Young Ballplayers, Support and Caution Are Key 2Health News:Beauty, Wisdom, Tradition and Youth Honor Public Servants 2Health News:Beauty, Wisdom, Tradition and Youth Honor Public Servants 3Health News:What's in a Video or a Sound Bite When You're Looking for a Therapist? 2Health News:What's in a Video or a Sound Bite When You're Looking for a Therapist? 3
Inquire...
... Subcutaneous Lead System Model 6996 ... the use of the Medtronic ... SQ design and implant technique ... and easy procedure, and high ...
... Spiral HP catheters feature 20 bipolar-spaced ... the highest degree of mapping resolution ... mapping via a 20-pole catheter enables ... potentials than with 10-pole catheter systems. ...
The Verity ADx pacemaker family, which includes the world's longest lasting single- and dual-chamber pacemakers, provides clinicians with a variety of feature options and header configurations to mee...
Medicine Products: