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Omeros Elucidates Mechanism of its PDE7 Inhibitors in Addiction
Date:3/19/2013

ing. We look forward to evaluating OMS527 in humans, and we are advancing through toxicology studies in preparation for clinical trials later this year."

About Omeros' PDE7 Programs
Omeros' phosphodiesterase 7 (PDE7) program is based on its discoveries of previously unknown links between PDE7 and any addiction or compulsive disorder and between PDE7 and any movement disorders, such as Parkinson's disease. PDE7 appears to modulate the dopaminergic system, which plays a significant role in regulating both addiction and movement. Omeros believes that PDE7 inhibitors could be effective therapeutics for the treatment of addiction and compulsive disorders as well as movement disorders. Data generated in preclinical studies support both of these potential indications. Omeros also believes that it controls the worldwide rights to any PDE7 inhibitor for the treatment of any movement disorder, including Parkinson's disease, restless leg syndrome and Huntington's disease.  Omeros has licensed its PDE7 inhibitors from Daiichi Sankyo Co., Ltd. for worldwide exclusivity in the fields of movement disorders, addictions and compulsive disorders.

About Addiction
Addiction is a significant medical problem with major socioeconomic impact. In the United States alone, the total socioeconomic cost of addiction is estimated at $484 billion per year, which is more than 60% greater than that for cancer and diabetes combined. Sales of current addiction medications exceed $4.4 billion worldwide, though they are either largely ineffective or have significant side-effects.

About Omeros Corporation
Omeros is a clinical-stage biopharmaceutical company committed to discovering, developing and commercializing products targeting inflammation, coagulopathies and disorders of the central nervous system. The Company's most clinically advanced product candidates, OMS302 for lens replacement surgery and OMS103HP for arthroscopy, are derived
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