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Omeros Corporation Reports First Quarter 2013 Financial Results
Date:5/10/2013

mary safety data expected to support the initiation of OMS721 clinical studies in mid-year 2013. The pharmacokinetic results in primates demonstrated that subcutaneous administration of OMS721 resulted in maximal inhibition of the lectin pathway within six hours of administration and maintained it for two or more weeks. In addition, the bioavailability and pharmacokinetics observed in both species are expected to support subcutaneous administration in patients at a frequency of once weekly, bi-monthly or possibly at even longer intervals.
  • Announced the successful completion of the 90-day safety database lock in the second of Omeros' two pivotal Phase 3 clinical trials evaluating OMS302 in patients undergoing intraocular lens replacement surgery. OMS302, added to standard irrigation solution used during ophthalmological procedures, is Omeros' proprietary PharmacoSurgery™ product designed to maintain intraoperative mydriasis and reduce postoperative pain and irritation resulting from cataract and other lens replacement surgery. Omeros intends to submit a New Drug Application for OMS302 to the U.S. Food and Drug Administration this quarter and a Marketing Authorization Application to the European Medicines Agency in mid-2013.
  • Reported that its proprietary Cellular Redistribution Assay technology, which to date has successfully "unlocked" 46 of the 80 total Class A orphan G protein-coupled receptors (GPCRs) for drug development, has identified small molecules that interact with a Class B GPCR. Like the Class A GPCRs, Class B receptors are important players in a broad range of disorders, having been linked to various types of cancer (e.g., breast, brain, prostate, kidney, liver, pancreatic and gastrointestinal); multiple sclerosis, attention deficit-hyperactivity, learning and memory impairments, depression and other neuropsychiatric disorders; multiple metabolic disorders including diabetes and obesity; immunologic disorders; osteoporosis and i
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    1. Omeros Announces $16.2 Million Registered Direct Offering of Common Stock
    2. Omeros Ophthalmology Product OMS302 Granted Eligibility for European Centralized Review
    3. Omeros to Present Additional OMS302 Clinical Data at the Annual ASCRS and ASOA Symposium and Congress
    4. Omeros Files Orphan Drug Application for Treatment of Atypical Hemolytic Uremic Syndrome with OMS721
    5. Omeros Announces that GPR17 Antagonists Improve Function in Model of Multiple Sclerosis
    6. Omeros Announces Positive OMS721 Data in Model of Thrombotic Microangiopathy
    7. Omeros to Present at the 2013 Future Leaders in the Biotech Industry Conference
    8. Omeros Announces Toxicology Data that Support Advancing MASP-2 Inhibitor into Clinical Trials
    9. Omeros Announces Successful Completion of PDE10 Phase 1 Multiple Ascending Dose Trial
    10. Omeros Elucidates Mechanism of its PDE7 Inhibitors in Addiction
    11. Omeros to Present at the Cowen and Company 33rd Annual Health Care Conference
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