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Omeros Announces Toxicology Data that Support Advancing MASP-2 Inhibitor into Clinical Trials
Date:3/28/2013

maintained it for two or more weeks. In addition, the bioavailability and pharmacokinetics observed in both species are expected to support subcutaneous administration in patients at a frequency of once weekly, bi-monthly or possibly at even longer intervals. The only currently approved complement inhibitor requires an intravenous infusion lasting 30 minutes or longer in the hospital or doctor's office.  Subcutaneous dosing avoids the complexity and inconvenience of intravenous infusion and would allow patients to self-administer OMS721 at home.

"As we wrap up our CTA-enabling studies, OMS721 continues to impress with its potential competitive advantages, including subcutaneous administration, convenient dosing, and maintenance of the acquired immune response to infection," stated Gregory A. Demopulos , M.D., chairman and chief executive officer of Omeros. "OMS721 holds significant promise to treat a wide range of immune-related disorders, and today's data further underscore the commercial opportunities for OMS721.  We plan to focus initially on aHUS, a rare and life-threatening indication seen most commonly in children. Submission of our CTA is expected next quarter, and we look forward to evaluating the drug product soon in clinical trials."

About Omeros' MASP-2 Program

Omeros controls the worldwide rights to MASP-2 and all therapeutics targeting MASP-2, a novel pro-inflammatory protein target involved in activation of the complement system, which is an important component of the immune system. The complement system plays a role in the inflammatory response and becomes activated as a result of tissue damage or microbial infection. MASP-2 appears to be unique to, and required for the function of, one of the principal complement activation pathways, known as the lectin pathway. Importantly, inhibition of MASP-2 does not appear to interfere with the antibody-dependent classical complement activation pathwa
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SOURCE Omeros Corporation
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