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Omeros Announces Publication of Data From Antifibrinolytic Program
Date:2/10/2011

SEATTLE, Feb. 10, 2011 /PRNewswire/ -- Omeros Corporation (Nasdaq: OMER) today announced that research on the antifibrinolytic agents it is developing has been published in the February 11, 2011 issue of the Journal of Biological Chemistry and selected by the editors as one of the top one percent of papers reviewed by the Journal in terms of significance and overall importance. This work from the laboratory of S. Paul Bajaj, Ph.D., demonstrates that unique antifibrinolytic agents can be derived from tissue factor pathway inhibitor-2 (TFPI-2). Omeros recently announced that it holds an exclusive license to these agents.

The authors of this paper exploited structural differences between the fibrinolytic enzyme plasmin and enzymes of the coagulation cascade to design a plasmin-selective inhibitor to replace Trasylol®, which was withdrawn from the market in 2008.  Because plasmin degrades fibrin clots, a drug that inhibits plasmin may have potential utility for reducing blood loss due to trauma or surgery.

Prior to withdrawal from the market for safety concerns, Trasylol® had been shown in a number of studies to be more effective at reducing blood loss than the other two most commonly used antifibrinolytic agents on the market today, tranexamic acid and epsilon aminocaproic acid.  While Trasylol® is a potent inhibitor of plasmin, it is non-selective. In addition to plasmin, it significantly inhibits kallikrein and Factor XIa, two enzymes important in promoting clotting, and their inhibition can increase bleeding. Trasylol® was found to be associated with a number of safety issues, including increased mortality. Further, it is a bovine protein associated with anaphylactic reactions. While the specific cause of increased death remains unknown, an often-cited explanation is the lack of specificity of Trasylol®.

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SOURCE Omeros Corporation
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