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Omeros Announces Expansion of Potential Indications for PDE7 Inhibitors
Date:5/5/2011

SEATTLE, May 5, 2011 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today announced that its phosphodiesterase 7 (PDE7) inhibitors demonstrated robust efficacy in animal models of nicotine addiction.  These data add to earlier studies showing strong effects in models of cocaine addiction as well as binge eating.  Omeros' PDE7 program was founded on the Company's discovery of a previously unknown link between PDE7 and any movement disorder, such as Parkinson's disease.  Omeros believes that it also is the first to link PDE7 to any addiction or compulsive behavior, and is now advancing PDE7 inhibitors for the treatment of these as well as movement disorders. Omeros is collaborating on this program with both the National Institute on Drug Abuse (NIDA) and The Michael J. Fox Foundation.

The studies, conducted by well-recognized addiction researcher R. Ciccocioppo, Ph.D., and his colleagues at the University of Camarino, demonstrated that PDE7 inhibitors reduced nicotine self-administration and inhibited relapse induced by cues and stress.  Smoking is the leading cause of preventable disease, disability and death in the United States, and it is estimated that 1.3 billion people worldwide, or approximately 20% of the world's population, are smokers. The smoking cessation market was estimated at $3.1 billion in 2007. Chantix® (varenicline) is the pharmaceutical market leader for the treatment of nicotine addiction.  However, Chantix® received a black box warning from the U.S. Food and Drug Administration highlighting the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking the drug.  PDE7 inhibitors are thought to exert their effect through a different mechanism than Chantix® and, therefore, may not have these side effects.

PDE7 appears to modulate the
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